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Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats

  • Journal of Korean Medicine for Obesity Research
  • Abbr : J Korean Med Obes Res
  • 2017, 17(2), pp.96-100
  • Publisher : The Society of Korean Medicine for Obesity Research
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Published : December 30, 2017

Min-Jee Kim 1 Hojun Kim 2 Myeong-Jong Lee 2

1동국대학교(경주캠퍼스) 한의학연구소
2동국대학교

Accredited

ABSTRACT

Objectives: Samjung-hwan (SJH) is a Korean herbal formula that has been used for antilipidemic,antioxidant, and antidepressant effects. As a part of safety evaluation, single oral dose toxicitystudy of modified SJH in Sprague-Dawley (SD) rats was carried out. Methods: Modified SJH extract was administered orally in male and female SD rats at dose of5,000 mg/kg. After single oral administration of modified SJH, we monitored the changes ofmortalities, clinical signs, and body weight daily for 14 days. Gross necropsy findings were alsoevaluated at the end of the experiment. Results: Modified SJH extract did not induce any toxic signs in the changes of mortalities, clinicalsigns, and body weight. There were also observed no gross necropsy findings in rats. Conclusions: As results, the approximate lethal dose of modified SJH extract in SD rats wasconsidered to be over 5,000 mg/kg. This suggests that modified SJH is safe herbal formula forthe treatment with

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