@article{ART002303015},
author={Min-Jee Kim and Hojun Kim and Myeong-Jong Lee},
title={Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats},
journal={Journal of Korean Medicine for Obesity Research},
issn={1976-9334},
year={2017},
volume={17},
number={2},
pages={96-100}
TY - JOUR
AU - Min-Jee Kim
AU - Hojun Kim
AU - Myeong-Jong Lee
TI - Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats
JO - Journal of Korean Medicine for Obesity Research
PY - 2017
VL - 17
IS - 2
PB - The Society of Korean Medicine for Obesity Research
SP - 96
EP - 100
SN - 1976-9334
AB - Objectives: Samjung-hwan (SJH) is a Korean herbal formula that has been used for antilipidemic,antioxidant, and antidepressant effects. As a part of safety evaluation, single oral dose toxicitystudy of modified SJH in Sprague-Dawley (SD) rats was carried out.
Methods: Modified SJH extract was administered orally in male and female SD rats at dose of5,000 mg/kg. After single oral administration of modified SJH, we monitored the changes ofmortalities, clinical signs, and body weight daily for 14 days. Gross necropsy findings were alsoevaluated at the end of the experiment.
Results: Modified SJH extract did not induce any toxic signs in the changes of mortalities, clinicalsigns, and body weight. There were also observed no gross necropsy findings in rats.
Conclusions: As results, the approximate lethal dose of modified SJH extract in SD rats wasconsidered to be over 5,000 mg/kg. This suggests that modified SJH is safe herbal formula forthe treatment with
KW - Samjung-hwan;Safety;Single dose toxicity
DO -
UR -
ER -
Min-Jee Kim, Hojun Kim and Myeong-Jong Lee. (2017). Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats. Journal of Korean Medicine for Obesity Research, 17(2), 96-100.
Min-Jee Kim, Hojun Kim and Myeong-Jong Lee. 2017, "Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats", Journal of Korean Medicine for Obesity Research, vol.17, no.2 pp.96-100.
Min-Jee Kim, Hojun Kim, Myeong-Jong Lee "Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats" Journal of Korean Medicine for Obesity Research 17.2 pp.96-100 (2017) : 96.
Min-Jee Kim, Hojun Kim, Myeong-Jong Lee. Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats. 2017; 17(2), 96-100.
Min-Jee Kim, Hojun Kim and Myeong-Jong Lee. "Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats" Journal of Korean Medicine for Obesity Research 17, no.2 (2017) : 96-100.
Min-Jee Kim; Hojun Kim; Myeong-Jong Lee. Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats. Journal of Korean Medicine for Obesity Research, 17(2), 96-100.
Min-Jee Kim; Hojun Kim; Myeong-Jong Lee. Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats. Journal of Korean Medicine for Obesity Research. 2017; 17(2) 96-100.
Min-Jee Kim, Hojun Kim, Myeong-Jong Lee. Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats. 2017; 17(2), 96-100.
Min-Jee Kim, Hojun Kim and Myeong-Jong Lee. "Single Oral Dose Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats" Journal of Korean Medicine for Obesity Research 17, no.2 (2017) : 96-100.
