Journal of Korean Medicine for Obesity Research 2023 KCI Impact Factor : 0.43
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pISSN : 1976-9334 / eISSN : 2288-1522
- https://journal.kci.go.kr/jkomor
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Effect of Eriobotrya folium on Local Fat via Regulation of Lipase Secretion
- Journal of Korean Medicine for Obesity Research
- Abbr : J Korean Med Obes Res
- 2017, 17(2), pp.101-110
- Publisher : The Society of Korean Medicine for Obesity Research
- Research Area : Medicine and Pharmacy > Korean Medicine
- Published : December 30, 2017
이운규 1, Yang Woong Mo 1, Choi You Yeon 1
1경희대학교
Accredited
ABSTRACT
Objectives: In this study, the lipolytic effects of Eriobotrya folium extract (EFE) on local fat wasinvestigated in high fat diet (HFD)-induced obesity mouse and 3T3-L1 adipocytes.
Methods: C57BL/6J mice (5 weeks) were fed HFD for 6 weeks to induce obesity. EFE (20 mg/ml,100 l) or saline (100 l) as a normal control was injected into left inguinal fat pad region, 3 timesper a week for last 2 weeks. After sacrifice, body weight, and histological changes of the inguinalfat pad were evaluated. The expressions of hormone-sensitive lipase (HSL) and adiposetriglyceride lipase (ATGL) in inguinal fat pad were analyzed by Western blotting. Also, lipidaccumulation and lipases release were determined in 3T3-L1 adipocytes by oil red o staining.
Results: EFE significantly reduced the weight of inguinal fat pad and the size of adipocytes inHFD-induced obesity mice compared to control. The treatment of EFE up-regulated theexpressions of HSL and ATGL in inguinal fat pads of obesity mice, as well as 3T3-L1 adipocytes.
In addition, EFE inhibited the lipid accumulation in 3T3-L1 adipocytes in a dose dependentmanner.
Conclusions: EFE showed lipolytic effect on local fat of HFD-induced obesity mice byup-regulation of the lipases secretion. This suggests that EFE could be considered as anti-obesesubstance with lipolytic property on local fat.
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