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Effect of Eriobotrya folium on Local Fat via Regulation of Lipase Secretion

  • Journal of Korean Medicine for Obesity Research
  • Abbr : J Korean Med Obes Res
  • 2017, 17(2), pp.101-110
  • Publisher : The Society of Korean Medicine for Obesity Research
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Published : December 30, 2017

이운규 1 Woong Mo Yang 1 You Yeon Choi 1

1경희대학교

Accredited

ABSTRACT

Objectives: In this study, the lipolytic effects of Eriobotrya folium extract (EFE) on local fat wasinvestigated in high fat diet (HFD)-induced obesity mouse and 3T3-L1 adipocytes. Methods: C57BL/6J mice (5 weeks) were fed HFD for 6 weeks to induce obesity. EFE (20 mg/ml,100 l) or saline (100 l) as a normal control was injected into left inguinal fat pad region, 3 timesper a week for last 2 weeks. After sacrifice, body weight, and histological changes of the inguinalfat pad were evaluated. The expressions of hormone-sensitive lipase (HSL) and adiposetriglyceride lipase (ATGL) in inguinal fat pad were analyzed by Western blotting. Also, lipidaccumulation and lipases release were determined in 3T3-L1 adipocytes by oil red o staining. Results: EFE significantly reduced the weight of inguinal fat pad and the size of adipocytes inHFD-induced obesity mice compared to control. The treatment of EFE up-regulated theexpressions of HSL and ATGL in inguinal fat pads of obesity mice, as well as 3T3-L1 adipocytes. In addition, EFE inhibited the lipid accumulation in 3T3-L1 adipocytes in a dose dependentmanner. Conclusions: EFE showed lipolytic effect on local fat of HFD-induced obesity mice byup-regulation of the lipases secretion. This suggests that EFE could be considered as anti-obesesubstance with lipolytic property on local fat.

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