Effects of Pueraria lobata on Obesity Related Hormones in Rats with Estrogen Deficiency (갈근 추출물이 에스트로겐 결핍 Rat의 비만관련 호르몬에 미치는 영향)

Seon-Eun Baek (백선은); 백지윤; Kang Ki Sung (강기성); Jeong-Eun Yoo (유정은)

Effects of Pueraria lobata on Obesity Related Hormones in Rats with Estrogen Deficiency

Journal of Korean Medicine for Obesity Research
Abbr : J Korean Med Obes Res
2017, 17(2), pp.111-118
Publisher : The Society of Korean Medicine for Obesity Research
Research Area : Medicine and Pharmacy > Korean Medicine
Published : December 30, 2017

Seon-Eun Baek ¹, 백지윤 ², Kang Ki Sung ², Jeong-Eun Yoo ¹

¹대전대학교
²가천대학교

Accredited

ABSTRACT

Objectives: This study was conducted to evaluate the effects of Pueraria lobata (PL) extract onobesity related hormones in rats with estrogen deficiency. Methods: The experiments were performed with the use of ovariectomized rats asestrogen-deficient obesity rat model. They were grouped Normal (sham operation group),Control (ovariectomy group), 50 mg/kg PL (ovariectomy group＋50 mg/kg of PL), 100 mg/kg PL(ovariectomy group＋100 mg/kg of PL), 200 mg/kg PL (ovariectomy group＋200 mg/kg of PL). PL extract was orally administered for 8 weeks once a day. Body weights and serum levels ofhormones, such as leptin, estradiol, cholecystokinin (CCK), ghrelin, and adiponectin wereestimated by ELISA. Results: PL extract significantly decreased body weight, the serum levels of leptin inestrogen-deficient obesity rats. PL extract significantly increased the serum levels of estradioland CCK. However, PL extract did not directly effect on the levels of ghrelin and adiponectin inestrogen-deficient obesity rats. Conclusions: It is concluded that PL extract reduced body weight, and regulate the hormonesrelated to energy metabolism. PL extract decreased the serum levels of leptin. PL extractincreased the serum levels of estradiol and CCK. These results indicate that PL might havepotentials for treatment of obesity and complications during the menopause caused byestrogen-deficiency. Key Words: Obesity, Pueraria

KEYWORDS

Obesity, Pueraria lobata, Menopause, Estrogens, Hormones

Citation status

* References for papers published after 2023 are currently being built.

[journal] 양미성 / 2008 / A Literature Review on Obesity in Postmenopausal Women / 한방비만학회지 / 한방비만학회 8(2) : 1~13

[book] Kim JG / 2009 / Management of menopausal women / Kunja Publisher : 341~347

[web] Korea Centers for Disease Control and Prevention (KCDC) / 2015 Health behavior and chronic disease statistics / KCDC / https://knhanes.cdc.go.kr/knhanes/sub04/sub04_03.do

[journal] Hamed S / 2015 / Estrogen metabolism and breast cancer / Cancer Lett 356(20) : 231~243

[journal] 김정민 / 2017 / The Effect of Oral Administration at Herbal Medicines in Animal Models on Obesity: A Review of Animal Study Reports Published in Korea after 2010 / 한방재활의학과학회지 / 한방재활의학과학회 27(3) : 13~32

[journal] 신희종 / 2012 / Effects of Pueraria lobata on Body Weight and Gene Expression in Obese Rats Muscle with Estrogen Deficiency / 대한한방부인과학회지 / 대한한방부인과학회 25(3) : 71~84

[journal] 신윤상 / 2014 / The effects of Pueraria lobata extract on gene expression in liver tissue of rat with estrogen-deficient obesity / 대한예방한의학회지 / 대한예방한의학회 18(3) : 117~128

[journal] Koon CM / 2013 / Gene expression profiling on the molecular action of danshengegen formula in a randomized placebo-controlled trial of postmenopausal women with hypercholesterolemia / Evid Based Complement Alternat Med 2013 : 703705~

[book] College of Korean Medicine Textbook Compilation Committee / 2010 / Korean medicine pharmacology / Shinil-Books : 414~

[journal] Pedersen SB / 2004 / Estrogen controls lipolysis by up-regulating alpha2A adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution / J. Clin. Endocrinol Metab 89(4) : 1869~1878

[journal] Samat A / 2008 / Pharmacotherapy for obesity in menopausal women / Menopause Int 14(2) : 57~62

[journal] Franco OH / 2016 / Use of plant-based therapies and menopausal symptoms: a systematic review and meta-analysis / JAMA 315(23) : 2554~2563

[journal] Yamabe N / 2015 / Estriol blunts postprandial blood glucose rise in male rats through regulating intestinal glucose transporters / Am J Physiol Endocrinol Metab 308(5) : 370~379

[book] Choi YJ / 2013 / Basic medical endocrinology / World Science : 151~174

[journal] Margetic S / 2002 / Leptin: a review of its peripheral actions and interactions / Int J Obes Relat Metab Disord 26(11) : 1407~1433

[journal] Jéquier E / 2002 / Leptin signaling, adiposity, and energy balance / Ann N Y Acad Sci 967(1) : 379~388

[journal] Clegg DJ / 2006 / Gonadal hormones determine sensitivity to central leptin and insulin / Diabetes 55(4) : 978~987

[journal] Ainslie DA / 2001 / Estrogen deficiency causes central leptin insensitivity and increased hypothalamic neuropeptide Y / Int J Obes Relat Metab Disord 25(11) : 1680~1688

[journal] Meli R / 2004 / Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats / Endocrinology 145(7) : 3115~3121

[journal] Nigro E / 2014 / New insight into adiponectin role in obesity and obesity-related diseases / Biomed Res Int 2014 : 658913~

[journal] Sangiao-Alvarellos S / 2009 / Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion / Endocrinology 150(10) : 4562~4574

[journal] Bowen J / 2006 / Energy intake, ghrelin, and cholecystokinin after different carbohydrate and protein preloads in overweight men / J Clin Endocrinol Metab 91(4) : 1477~1483

This paper was written with support from the National Research Foundation of Korea.

KJCKorea
Journal Central

Journal of Korean Medicine for Obesity Research 2023 KCI Impact Factor : 0.43