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The Mixed Herbal Extract, CAPA, Prevents Obesity and Glucose Intolerance in Obese Mice

  • Journal of Korean Medicine for Obesity Research
  • Abbr : J Korean Med Obes Res
  • 2017, 17(2), pp.119-126
  • Publisher : The Society of Korean Medicine for Obesity Research
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Published : December 30, 2017

송미영 1

1동국대학교

Accredited

ABSTRACT

Objectives: This study investigated the effects of the mixed herbal extract from Cinnamomumcassia Blume, Atractylodes macrocephala Koidzumi, Pueraria lobata Benth, and Aconitumcarmichaeli Debx (CAPA) on obesity and glucose tolerance in obese mice. Methods: Animals were divided in 6 groups, normal diet, high fat diet (HFD), HFD with CAPA 100mg/kg (CAPA 100), CAPA 300 mg/kg (CAPA 300), and metformin 200 mg/kg or lorcaserin 10mg/kg as positive controls, and treated for 16 weeks. Body weight, food intake, fasting bloodglucose, and body temperature were checked every week and then organs, blood serums werecollected after treatment. The oral glucose tolerance test was also carried out after treatment. Results: Compared to HFD, CAPA extract treated mice showed significant decreases in bodyweight, adipose tissue weight, lipid accumulations in liver and serum lipid levels without areduction of food intake. And fasting glucose and glucose tolerance were all improved in the CAPAtreated mice. Conclusions: Our results suggest that CAPA extract can prevent diet induced obesity and glucoseintolerance without a reduction of energy intake in obese mice

Citation status

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This paper was written with support from the National Research Foundation of Korea.