@article{ART002667532},
author={Sun Mi Park and Young Kyun Kim and Sun Ae Yu and Cho Sungwoo and Myeong Hwa Lee and Jae Eun Lim and Kyoung-min Kim},
title={Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice},
journal={Journal of Korean Medicine for Obesity Research},
issn={1976-9334},
year={2020},
volume={20},
number={2},
pages={88-96},
doi={10.15429/jkomor.2020.20.2.88}
TY - JOUR
AU - Sun Mi Park
AU - Young Kyun Kim
AU - Sun Ae Yu
AU - Cho Sungwoo
AU - Myeong Hwa Lee
AU - Jae Eun Lim
AU - Kyoung-min Kim
TI - Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice
JO - Journal of Korean Medicine for Obesity Research
PY - 2020
VL - 20
IS - 2
PB - The Society of Korean Medicine for Obesity Research
SP - 88
EP - 96
SN - 1976-9334
AB - Objectives: This study was designed to investigate the effects of Valerianae Radix et Rhizoma Methanol Extract (VRME) on serum lipid levels in a high-fat diet-induced hyperlipidemic mice.
Methods: Each 8 C57BL/6 mice were randomly assigned to normal diet group, high-fat diet control group, high-fat diet plus 100 mg/kg/day of VRME group. In order to induce hyperlipidemia, high-fat diets were supplied to control group and VRME group for four weeks. Normal diet group were supplied with general feed for four weeks. After that control group supplied only high-fat diets as feed, VRME group received oral administration of VRME with high-fat diets for three weeks. and normal diet group were supplied with general feed for three weeks. After seven weeks, the changes in the body weight, the plasma levels of total cholesterol, triglyceride, high density lipoprotein-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood glucose in serum were measured.
Results: In our results, VRME did not affects weight gain, serum AST and ALT in high-fat diet-induced hyperlipidemic mice. Oral administration of VRME lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. and oral administration of VRME lowered blood glucose significantly.
Conclusions: These results suggest that VRME could act as a potent antihyperlipidemic in therapeutics for hyperlipidemia.
KW - Valeriana fauriei Briquet;Valerianae Radix et Rhizoma;Hyperlipidemias
DO - 10.15429/jkomor.2020.20.2.88
ER -
Sun Mi Park, Young Kyun Kim, Sun Ae Yu, Cho Sungwoo, Myeong Hwa Lee, Jae Eun Lim and Kyoung-min Kim. (2020). Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice. Journal of Korean Medicine for Obesity Research, 20(2), 88-96.
Sun Mi Park, Young Kyun Kim, Sun Ae Yu, Cho Sungwoo, Myeong Hwa Lee, Jae Eun Lim and Kyoung-min Kim. 2020, "Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice", Journal of Korean Medicine for Obesity Research, vol.20, no.2 pp.88-96. Available from: doi:10.15429/jkomor.2020.20.2.88
Sun Mi Park, Young Kyun Kim, Sun Ae Yu, Cho Sungwoo, Myeong Hwa Lee, Jae Eun Lim, Kyoung-min Kim "Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice" Journal of Korean Medicine for Obesity Research 20.2 pp.88-96 (2020) : 88.
Sun Mi Park, Young Kyun Kim, Sun Ae Yu, Cho Sungwoo, Myeong Hwa Lee, Jae Eun Lim, Kyoung-min Kim. Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice. 2020; 20(2), 88-96. Available from: doi:10.15429/jkomor.2020.20.2.88
Sun Mi Park, Young Kyun Kim, Sun Ae Yu, Cho Sungwoo, Myeong Hwa Lee, Jae Eun Lim and Kyoung-min Kim. "Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice" Journal of Korean Medicine for Obesity Research 20, no.2 (2020) : 88-96.doi: 10.15429/jkomor.2020.20.2.88
Sun Mi Park; Young Kyun Kim; Sun Ae Yu; Cho Sungwoo; Myeong Hwa Lee; Jae Eun Lim; Kyoung-min Kim. Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice. Journal of Korean Medicine for Obesity Research, 20(2), 88-96. doi: 10.15429/jkomor.2020.20.2.88
Sun Mi Park; Young Kyun Kim; Sun Ae Yu; Cho Sungwoo; Myeong Hwa Lee; Jae Eun Lim; Kyoung-min Kim. Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice. Journal of Korean Medicine for Obesity Research. 2020; 20(2) 88-96. doi: 10.15429/jkomor.2020.20.2.88
Sun Mi Park, Young Kyun Kim, Sun Ae Yu, Cho Sungwoo, Myeong Hwa Lee, Jae Eun Lim, Kyoung-min Kim. Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice. 2020; 20(2), 88-96. Available from: doi:10.15429/jkomor.2020.20.2.88
Sun Mi Park, Young Kyun Kim, Sun Ae Yu, Cho Sungwoo, Myeong Hwa Lee, Jae Eun Lim and Kyoung-min Kim. "Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice" Journal of Korean Medicine for Obesity Research 20, no.2 (2020) : 88-96.doi: 10.15429/jkomor.2020.20.2.88