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A Study on the Detection of Similarity GPCRs by using protein Secondary structure

  • Journal of The Korea Society of Computer and Information
  • Abbr : JKSCI
  • 2009, 14(1), pp.73-80
  • Publisher : The Korean Society Of Computer And Information
  • Research Area : Engineering > Computer Science

구자효 1 한찬명 1 YOON YOUNG WOO 1

1영남대학교

Accredited

ABSTRACT

G protein-coupled receptors(GPCRs) family is a cell membrane protein, and plays an important role in a signaling mechanism which transmits external signals through cell membranes into cells. But, GPCRs each are known to have various complex control mechanisms and very unique signaling mechanisms. Structural features, and family and subfamily of GPCRs are well known by function, and accordingly, the most fundamental work in studies identifying the previous GPCRs is to classify the GPCRs with given protein sequences. Studies for classifying previously identified GPCRs more easily with mathematical models have been mainly going on. In this paper Considering that functions of proteins are determined by their stereoscopic structures, the present paper proposes a method to compare secondary structures of two GPCRs having different amino acid sequences, and then detect an unknown GPCRs assumed to have a same function in databases of previously identified GPCRs.

Citation status

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