@article{ART002109916},
author={YOOK KEUN-DOL},
title={Antimicrobial activity and cytotoxicity test of Scrophularia ningpoensis hemsl extracts against Klebsiella pneumoniae},
journal={Journal of The Korea Society of Computer and Information},
issn={1598-849X},
year={2016},
volume={21},
number={5},
pages={135-139}
TY - JOUR
AU - YOOK KEUN-DOL
TI - Antimicrobial activity and cytotoxicity test of Scrophularia ningpoensis hemsl extracts against Klebsiella pneumoniae
JO - Journal of The Korea Society of Computer and Information
PY - 2016
VL - 21
IS - 5
PB - The Korean Society Of Computer And Information
SP - 135
EP - 139
SN - 1598-849X
AB - Scrophularia ningpoensis hemsl has been traditionally used in China and Vietnam for treatment of bacteria, atopy, pimple, tonsillitis, angina and encephalitis for a long time. The main objectives of this study were to evaluate the antibacterial activity of the Scrophularia ningpoensis hemsl extract on biofilm formation of Klebsiella pneumoniae. Antibacterial activity was conducted using disc diffusion assay and minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) were determined using the broth micro dilution method in accordance to Clinical and Laboratory Standards Institute guidelines(CLSI). Furthermore, cytotoxicity on L929 were assessed using animal cell culture for the proliferation test(MTT cell assay) and the biofilm forming capacity of the K.
pneumoniae were determined using the colony forming unit (CFU) assay. The extract exhibited considerable antibacterial activity. K. pneumoniae was susceptible to the extract with the MIC and MBC of 0.1875 and 1.5 ㎎/㎖ respectively. Cytoxicity test in L929 showed no sign of toxicity at the concentration of 0.75㎎/㎖ and at the same concentration the extract caused inhibition of bacterial biofilm formation. The extract of Scrophularia ningpoensis hemsl possesses an in vitro antibacterial antibiofilm activities against K. pneumoniae, with no sign of cytoxicity on L929.
KW - Anitbacterials activities;Biofilm;Klebsiella pneumoniae;Scrophularia ningpoensis hemsl
DO -
UR -
ER -
YOOK KEUN-DOL. (2016). Antimicrobial activity and cytotoxicity test of Scrophularia ningpoensis hemsl extracts against Klebsiella pneumoniae. Journal of The Korea Society of Computer and Information, 21(5), 135-139.
YOOK KEUN-DOL. 2016, "Antimicrobial activity and cytotoxicity test of Scrophularia ningpoensis hemsl extracts against Klebsiella pneumoniae", Journal of The Korea Society of Computer and Information, vol.21, no.5 pp.135-139.
YOOK KEUN-DOL "Antimicrobial activity and cytotoxicity test of Scrophularia ningpoensis hemsl extracts against Klebsiella pneumoniae" Journal of The Korea Society of Computer and Information 21.5 pp.135-139 (2016) : 135.
YOOK KEUN-DOL. Antimicrobial activity and cytotoxicity test of Scrophularia ningpoensis hemsl extracts against Klebsiella pneumoniae. 2016; 21(5), 135-139.
YOOK KEUN-DOL. "Antimicrobial activity and cytotoxicity test of Scrophularia ningpoensis hemsl extracts against Klebsiella pneumoniae" Journal of The Korea Society of Computer and Information 21, no.5 (2016) : 135-139.
YOOK KEUN-DOL. Antimicrobial activity and cytotoxicity test of Scrophularia ningpoensis hemsl extracts against Klebsiella pneumoniae. Journal of The Korea Society of Computer and Information, 21(5), 135-139.
YOOK KEUN-DOL. Antimicrobial activity and cytotoxicity test of Scrophularia ningpoensis hemsl extracts against Klebsiella pneumoniae. Journal of The Korea Society of Computer and Information. 2016; 21(5) 135-139.
YOOK KEUN-DOL. Antimicrobial activity and cytotoxicity test of Scrophularia ningpoensis hemsl extracts against Klebsiella pneumoniae. 2016; 21(5), 135-139.
YOOK KEUN-DOL. "Antimicrobial activity and cytotoxicity test of Scrophularia ningpoensis hemsl extracts against Klebsiella pneumoniae" Journal of The Korea Society of Computer and Information 21, no.5 (2016) : 135-139.
