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@article{ART002149270},
author={Lee EunJu},
title={Mutations in the tyrosine kinase domain of the EGFR gene are rare in the Korean Oral Squamous Cell Carcinoma},
journal={Journal of The Korea Society of Computer and Information},
issn={1598-849X},
year={2016},
volume={21},
number={9},
pages={101-106}

TY - JOUR
AU - Lee EunJu
TI - Mutations in the tyrosine kinase domain of the EGFR gene are rare in the Korean Oral Squamous Cell Carcinoma
JO - Journal of The Korea Society of Computer and Information
PY - 2016
VL - 21
IS - 9
PB - The Korean Society Of Computer And Information
SP - 101
EP - 106
SN - 1598-849X
AB - The epidermal growth factor receptor(EGFR) protein kinase signaling is an important pathway in cancer development and recently reported that EGFR and its kinase domain molecules are mutated in various of cancers including head and neck cancer. Functional deregulation of EGFR due to mutations in coding exons and copy number amplification is the most common event in cancers, especially among receptor tyrosine kinases(TK). We have analyzed Korean oral squamous cell carcinomas (OSCC) cell lines for mutations in EGFRTK. Exons encoding the hot-spot regions in the TK domain of EGFR (exons 17 to 23) were amplified by using polymerase chain reaction(PCR) and sequenced directly. EGFR expression was also analyzed in 8 OSCC cell lines using western blotting. Data analysis of the EGFR exons 17 to 23 coding sequences did not show any mutations in the 8 OSCC cell lines that were analyzed. The absence of mutations indicate that protein overexpression might be responsible for activation rather than mutation.
KW - Receptor-Epidermal Growth Factor;protein-tyrosine kinase;carcinoma-squamous cell;Head and Neck Neoplasms;mouth neoplasms;exons
DO -
UR -
ER -

Lee EunJu. (2016). Mutations in the tyrosine kinase domain of the EGFR gene are rare in the Korean Oral Squamous Cell Carcinoma. Journal of The Korea Society of Computer and Information, 21(9), 101-106.

Lee EunJu. 2016, "Mutations in the tyrosine kinase domain of the EGFR gene are rare in the Korean Oral Squamous Cell Carcinoma", Journal of The Korea Society of Computer and Information, vol.21, no.9 pp.101-106.

Lee EunJu "Mutations in the tyrosine kinase domain of the EGFR gene are rare in the Korean Oral Squamous Cell Carcinoma" Journal of The Korea Society of Computer and Information 21.9 pp.101-106 (2016) : 101.

Lee EunJu. Mutations in the tyrosine kinase domain of the EGFR gene are rare in the Korean Oral Squamous Cell Carcinoma. 2016; 21(9), 101-106.

Lee EunJu. "Mutations in the tyrosine kinase domain of the EGFR gene are rare in the Korean Oral Squamous Cell Carcinoma" Journal of The Korea Society of Computer and Information 21, no.9 (2016) : 101-106.

Lee EunJu. Mutations in the tyrosine kinase domain of the EGFR gene are rare in the Korean Oral Squamous Cell Carcinoma. Journal of The Korea Society of Computer and Information, 21(9), 101-106.

Lee EunJu. Mutations in the tyrosine kinase domain of the EGFR gene are rare in the Korean Oral Squamous Cell Carcinoma. Journal of The Korea Society of Computer and Information. 2016; 21(9) 101-106.

Lee EunJu. Mutations in the tyrosine kinase domain of the EGFR gene are rare in the Korean Oral Squamous Cell Carcinoma. 2016; 21(9), 101-106.

Lee EunJu. "Mutations in the tyrosine kinase domain of the EGFR gene are rare in the Korean Oral Squamous Cell Carcinoma" Journal of The Korea Society of Computer and Information 21, no.9 (2016) : 101-106.