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@article{ART002639428},
author={Lee Mi Ran},
title={Root bark extract of Cudrania tricuspidata reduces LPS-induced inflammation in macrophages of atherogenic mice},
journal={Journal of The Korea Society of Computer and Information},
issn={1598-849X},
year={2020},
volume={25},
number={10},
pages={115-123},
doi={10.9708/jksci.2020.25.10.115}

TY - JOUR
AU - Lee Mi Ran
TI - Root bark extract of Cudrania tricuspidata reduces LPS-induced inflammation in macrophages of atherogenic mice
JO - Journal of The Korea Society of Computer and Information
PY - 2020
VL - 25
IS - 10
PB - The Korean Society Of Computer And Information
SP - 115
EP - 123
SN - 1598-849X
AB - In this paper, we propose to evaluate the potential anti-inflammatory properties of root bark extract of Cudrania (C.) tricuspidata on lipopolysaccharide (LPS)-induced inflammation in macrophages of apolipoprotein E (ApoE) knockout (ApoE -/- ) mice, murine model of atherosclerosis. Atherosclerosis is a chronic vascular inflammatory disease. C. tricuspidata is a small tree of the Moraceae family and its extract has anti-inflammatory activities. However, its role in the progress of atherosclerosis is not yet clear. To determine anti-inflammatory effects of C. tricuspidata in atherogenesis, we applied LPS in peritoneal macrophages of ApoE -/- mice and measured cell viability by CCK-8 and expression of pro-inflammatory cytokines by qRT-PCR following treatment with root bark extract of C. tricuspidata. Research data was expressed as differences between the cells treated with LPS and root bark extract and the cells treated with LPS alone (control) by a two-tailed non-parametric Mann–Whitney U-test using GraphPad Instat program. No cytotoxic effect was observed when the cells were treated with the extract at concentrations ≤ 100 ㎍/mL. The expression of inflammatory cytokines, including MCP-1, IL-1β, IFN-γ, TNF-α, and IL-6 were inhibited by the extract. These results indicated that the extract has an anti-inflammatory effect and therefore a possible role in the treatment of atherosclerosis.
KW - Cudrania tricuspidata;Lipopolysaccharide;Inflammation;Peritoneal macrophage;Atherosclerosis
DO - 10.9708/jksci.2020.25.10.115
ER -

Lee Mi Ran. (2020). Root bark extract of Cudrania tricuspidata reduces LPS-induced inflammation in macrophages of atherogenic mice. Journal of The Korea Society of Computer and Information, 25(10), 115-123.

Lee Mi Ran. 2020, "Root bark extract of Cudrania tricuspidata reduces LPS-induced inflammation in macrophages of atherogenic mice", Journal of The Korea Society of Computer and Information, vol.25, no.10 pp.115-123. Available from: doi:10.9708/jksci.2020.25.10.115

Lee Mi Ran "Root bark extract of Cudrania tricuspidata reduces LPS-induced inflammation in macrophages of atherogenic mice" Journal of The Korea Society of Computer and Information 25.10 pp.115-123 (2020) : 115.

Lee Mi Ran. Root bark extract of Cudrania tricuspidata reduces LPS-induced inflammation in macrophages of atherogenic mice. 2020; 25(10), 115-123. Available from: doi:10.9708/jksci.2020.25.10.115

Lee Mi Ran. "Root bark extract of Cudrania tricuspidata reduces LPS-induced inflammation in macrophages of atherogenic mice" Journal of The Korea Society of Computer and Information 25, no.10 (2020) : 115-123.doi: 10.9708/jksci.2020.25.10.115

Lee Mi Ran. Root bark extract of Cudrania tricuspidata reduces LPS-induced inflammation in macrophages of atherogenic mice. Journal of The Korea Society of Computer and Information, 25(10), 115-123. doi: 10.9708/jksci.2020.25.10.115

Lee Mi Ran. Root bark extract of Cudrania tricuspidata reduces LPS-induced inflammation in macrophages of atherogenic mice. Journal of The Korea Society of Computer and Information. 2020; 25(10) 115-123. doi: 10.9708/jksci.2020.25.10.115

Lee Mi Ran. Root bark extract of Cudrania tricuspidata reduces LPS-induced inflammation in macrophages of atherogenic mice. 2020; 25(10), 115-123. Available from: doi:10.9708/jksci.2020.25.10.115

Lee Mi Ran. "Root bark extract of Cudrania tricuspidata reduces LPS-induced inflammation in macrophages of atherogenic mice" Journal of The Korea Society of Computer and Information 25, no.10 (2020) : 115-123.doi: 10.9708/jksci.2020.25.10.115