Preparation and evaluation of hydrogels containing Loratadine for the treatment of allergic diseases (알레르기 질환 치료를 위한 로라타딘 함유 하이드로겔의 제조 및 평가)

Chul-Tae Kim (김철태); Kwang-Soon Kang (강광순)

doi:10.9708/jksci.2024.29.11.311

Preparation and evaluation of hydrogels containing Loratadine for the treatment of allergic diseases

Journal of The Korea Society of Computer and Information
Abbr : JKSCI
2024, 29(11), pp.311~316
DOI : 10.9708/jksci.2024.29.11.311
Publisher : The Korean Society Of Computer And Information
Research Area : Engineering > Computer Science
Received : November 4, 2024
Accepted : November 25, 2024
Published : November 29, 2024

Chul-Tae Kim ¹, Kwang-Soon Kang ²

¹건양대학교
²대전보건대학교

Accredited

ABSTRACT

Anti-histamines are drugs used to relieve allergic diseases such as urticaria. Loratadine is a second-generation ant-ihistamine that works better with fewer side effects such as sleepiness and headaches. However, even if the effect is good, it takes a long time for the effect to take a pill. The method of delivering drugs to the skin is a way to overcome these shortcomings and show quick effects. Therefore, hydrogels containing Loratadine were produced and their properties were evaluated. The content of Loratadine was more than 98%, and the uniformity of the contents was good. When manufacturing hydrogels, the higher the amount of carbomer, the higher the viscosity of the gel. As a result of evaluation of the prepared hydrogel, it was obtained that most of it fell within the range of commercially available gels.

KEYWORDS

Anti-Histamine, Loratadine, Hydrogel, Allergic disease, Carbomer

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[journal] F. Simons / 1994 / The Pharmacology and Use of H1-Receptor anstagonist Drugs / The New England Journala of Medicine 330(23) : 1663~1670

[journal] M. Buckley / 1997 / Mast Cell Activation in Arthritis : Detection of ⍺-and β-tryptase, Histamine and Eosinophil Cationic Proteinin Synovial Fluid / Clinical Science 93(4) : 363~370

[journal] Y. C. Lei / 2004 / Effects of Asian dust event particles on inflammation markers in peripheral blood and bronchoalveolar lavage in pulmonary hypertensive rats / Environmental Research 95(1) : 71~76

[journal] P. K. Min / 2001 / Effect of Yellow sand on respiratory flow in patients with bronchial asthma / Journal of Asthma, Allergy and Clinical Immunology 21 : 1179~1186

[journal] H. J. Kwon / 2002 / Effect of Asian dust storm events on daily mortality in Seoul, Korea / Environmental Research 90 : 1~5

[journal] M. Nakaya / 2009 / Prolonged allergen challenge in murine nasal allergic rhinitis : Nasal airway remodeling and adaptation of nasal airway responsiveness / Laryngoscope 117 : 881~885

[journal] H. S. Yoon / 1998 / An Assessment of Asthmatic Knowledge of School Teachers / Pediatric allergy and respiratory disease 8 : 179~189

[journal] M. Roushani / 2017 / Development of novel electrochemical sensor on the base of molecular imprinted polymer decorated on SiC nano particles modified glassy carbon electrode for selective determination of Loratadine / Materials Science and Engineering : C 71 : 1106~1114

[journal] G. W. Canonica / 2011 / Antihistaminic, anti-inflammatory, and antiallergic properties of the nonsedating second-generation antihistamine desloratadine : a review of the evidence / World Allergy Organization Jorunal 4 : 47~53

[journal] J. Menardo / 1997 / A review of loratadine in ter treatment of patients with allergic bronchial asthma / Clincal Therapeutics 19 : 1278~1293

[journal] A. Kantar / 1996 / Effect of cetirizine on plasma membrane of human eosinophils, neutrophils and platelets : a dose response study / European Journal of Pharmaceutical Sciences 4 : 101~107

[journal] Y. Wang / 2011 / Synthesis and antihistamine evaluations of novel loratadine analogues / Bioorganic & Medicinal Chemistry Letters 21 : 4454~4456

[journal] W. Crawford / 1998 / Comparative Efficacy of Terfenadine, Loratadine, and Astemizole in Perennial Allergic Rhinitis / Otolaryngology-Head and Neck Surgery 118 : 668~673

[journal] L. F. Delgado / 1998 / Evaluation of the Potential Cardiotoxicity of the Antihistamines Terfenadine, Astemizole, Loratadine, and Cetirizine in Atopic Children / Annals of Allergy, A Asthma & Immunology 80 : 333~337

[journal] E. Baek / 2011 / Preparation of Poloxamer-based Hydrogels Using Electron Beam and Their Evaluation for Buccal Mucoadhesive Drug Delivery / Polymer Korea 36(2) : 182~189

[journal] K. Kim / 2018 / Preparation and Electrochemical Performances Comparison of Carbon and Hydrogel Electrocatalysts for Seawater Battery / Journal of the Korean Electrochemical Society 21(4) : 61~67

[journal] G. Fang / 2021 / Hydrogels-based ophthalmic drug delivery systems for treatment of ocular diseases / Materials Science and Engineering : C : 112212~

[journal] Y. Zhan / 2021 / Advances in versatile anti-swelling polymer hydrogels / Materials Science and Engineering : C : 112208~

[journal] E. Tsanaktsidou / 2019 / On the synthesis and characterization of biofunctional hyaluronic acid based injectable hydrogels for the repair of cartilage lesions / European Polumer Journal 114 : 47~56

[journal] J. Lee / 2020 / Influence of N-vinyl-2-pyrrolidone and methacrylic acid on thermal curing process of 2-hydroxyethyl methacrylate hydrogel / Applied Ploymer 137 : 48622~

[journal] Y. Nho / 2004 / Evaluations of Poly(vinyl alcohol)/Alginate Hydrogels Cross-linked by g-ray Irradiation Technique / Macromolecular Research 12(2) : 219~224

[journal] K. Kim / 2008 / Preparation of High Molecular Weight Atactic Poly(vinyl alcohol) Hydrogel by Electron Beam Irradiation Technique / Polymer(Korea) 32(6) : 587~592

[journal] J. Park / 2011 / Preparation of Silver Nanoparticles on the Poly(vinyl alcohol)/ poly(ethylene glycol) Hydrogel / Journal of Radiation Industry 5(2) : 119~124

[journal] H. Kim / 2021 / Manufacture and evaluation of hydrogel preparations that are easy to use in emergency allergy situations / Journal of Digital Convergence 19(3) : 287~293

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Journal of The Korea Society of Computer and Information 2025 KCI Impact Factor : 1.01

Preparation and evaluation of hydrogels containing Loratadine for the treatment of allergic diseases

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Journal of The Korea Society of Computer and Information 2025 KCI Impact Factor : 1.01

Preparation and evaluation of hydrogels containing Loratadine for the treatment of allergic diseases

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