Beneficial effect of vitamin K on bone health (비타민 K의 골 건강 증진 효과)

장영호

Beneficial effect of vitamin K on bone health

Journal of Korean society of Dental Hygiene
Abbr : J Korean Soc Dent Hyg
2011, 11(4), pp.419~426
Publisher : Korean Society of Dental Hygiene
Research Area : Medicine and Pharmacy > Dentistry

장영호 ¹

¹안동과학대학

Accredited

ABSTRACT

Originally, vitamin K was defined as a factor for blood coagulation. Now more attention is focused on vitamin K for bone metabolism and bone health. Vitamin K is a coenzyme for glutamate carboxylase which converts glutamate residues to γ-carboxyglutamate(Gla) residues. Gla residues have calcium binding ability and bound to hydroxyapatite crystals in bone. Vitamin K promotes the carboxylation of osteocalcin and matrix Gla-protein,vitamin K-dependent proteins and improves bone mineral density and bone mass. Vitamin K deficiency causes reductions in bone mineral density and increases the risk of osteoporotic bone fractures, resulting from undercarboxylated osteocalcin. This paper is to provide a brief information of vitamin K and its role in bone health.

KEYWORDS

bone health, osteocalcin, vitamin K

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