Anticancer effect of methanol extract of Erigeron bonariensis on oral cancer cells (구강암 세포주에서 실망초 추출물의 항암효능)

Boonsil Jang (장분실); Lim, sun-a (임선아)

doi:10.13065/jksdh.20200070

Anticancer effect of methanol extract of Erigeron bonariensis on oral cancer cells

Journal of Korean society of Dental Hygiene
Abbr : J Korean Soc Dent Hyg
2020, 20(5), pp.763-771
DOI : 10.13065/jksdh.20200070
Publisher : Korean Society of Dental Hygiene
Research Area : Medicine and Pharmacy > Dentistry
Received : August 21, 2020
Accepted : September 30, 2020
Published : October 30, 2020

Boonsil Jang ¹, Lim, sun-a ²

¹서라벌대학교
²송원대학교

Accredited

ABSTRACT

Objectives: Erigeron bonariensis is a type of Erigeron found throughout the tropical and subtropical areas as one of the perennial plants or pioneer plants. It is known to show detoxifying, antipyretic, and anticancer effects for various cancers. However, there are no reports on the anticancer effect of E. bonariensis on oral cancer cells. In the present study, we investigated the effects of the methanol extract of Erigeron bonariensis (MEEB) on the inhibition of cell growth and induction of apoptosis in mucoepidermoid carcinoma (MEC) cell lines, including the MC3 and YD15 oral cancer cells. Methods: MC3 Cells were treated by dimethyl sulfoxide (DMSO) or methanol extracts of 20 various natural products 20 μg/mL for 48 hours and cell viability were analyzed as Trypan blue exclusion assay. The effects of MEEB treatment on the cell viability of MC3 and YD15 cells, for 48 h, were analyzed by Trypan blue exclusion assay. The anticancer efficacy and apoptosis of oral cancer cell lines were analyzed by western blot analysis. The statistical significance of differences between groups was analyzed by Student’s two-tailed t-test. A value of P<0.05 compared to the vehicle control was considered statistically significant. Results: Among 20 different naturally derived products, MEEB significantly inhibited cell viability and increased cleaved poly [ADP-ribose] polymerase 1 (PARP) protein in the MC3 and YD15 cells in a concentration-dependent manner. Conclusions: These results suggest that MEEB can be used as a natural anticancer drug for the treatment of human oral cancer.

KEYWORDS

Apoptosis, Cleaved PARP, Erigeron bonariensis, Oral cancer, Protein

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Journal of Korean society of Dental Hygiene 2023 KCI Impact Factor : 0.8

Anticancer effect of methanol extract of Erigeron bonariensis on oral cancer cells

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* References for papers published after 2023 are currently being built.

Journal of Korean society of Dental Hygiene 2023 KCI Impact Factor : 0.8

Anticancer effect of methanol extract of Erigeron bonariensis on oral cancer cells

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