Effects of non-surgical periodontal treatment with probiotic supplementation on metabolic dysfunction in patients with periodontitis: a retrospective study

Mu-Yeol Cho; Ji-Young Hwang; Je-Hyun Eom; Eun-Mi Choi; Jeong-Hoo Lee; Yeon-Jin Kim; Ju-Young Hwang; Hye-Sung Kim; In-Seong Hwang

doi:10.13065/jksdh.2025.25.2.2

Effects of non-surgical periodontal treatment with probiotic supplementation on metabolic dysfunction in patients with periodontitis: a retrospective study

Journal of Korean society of Dental Hygiene
Abbr : J Korean Soc Dent Hyg
2025, 25(2), pp.101~111
DOI : 10.13065/jksdh.2025.25.2.2
Publisher : Korean Society of Dental Hygiene
Research Area : Medicine and Pharmacy > Dentistry
Received : February 5, 2025
Accepted : April 3, 2025
Published : April 30, 2025

Mu-Yeol Cho ¹, Ji-Young Hwang ², Je-Hyun Eom ¹, Eun-Mi Choi ¹, Jeong-Hoo Lee ², Yeon-Jin Kim ², Ju-Young Hwang ², Hye-Sung Kim ¹, In-Seong Hwang ¹

¹Apple Tree Institute of Biomedical Science, Apple Tree Medical Foundation
²DOCSmedi Co., Ltd.

Accredited

ABSTRACT

Objectives: Probiotic supplementation, integrated into routine oral care, may improve periodontal status and metabolic function. In this retrospective longitudinal study, we evaluated the efficacy of probiotics added to non-surgical periodontal treatment (NSPT) in reducing the burden of oral pathogens and improving metabolic dysfunction. Methods: Twenty outpatients with chronic periodontitis and at least one metabolic abnormality underwent NSPT with daily probiotic supplementation for 12 weeks. Baseline and post-intervention assessments included clinical indices, blood pressure, and blood biomarkers (HbA1c, fasting glucose, and lipid profiles), with analysis of oral pathogens using qPCR. Results: Among the 13 eligible participants, probiotics with NSPT resulted in significant reductions in HbA1c (-0.3%, p<0.001), and systolic blood pressure (-9.6 mmHg, p<0.001), and Tannerella forsythia (p<0.05) levels, along with decreasing trends in other pathogens. However, no significant changes were noted in periodontal indices, including probing pocket depth and bleeding on probing, nor in lipid profiles. Conclusions: These f indings suggest that probiotic supplementation with NSPT may improve glycemic control and systolic blood pressure but may have a limited effect on periodontal indices, warranting larger trials to confirm its potential.

KEYWORDS

Blood glucose, Blood pressure, Periodontal therapy, Periodontitis, Probiotics

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