Indonesia and Nepal, which are in the World Health Organization South-East Asia Region, are the countries with the highest numbers of confirmed cases and deaths since the start of the COVID-19 pandemic outside of the Region of the Americas and the European Region. Since its first confirmed case on March 2nd, Indonesia has reported 100,303 cases and 4,838 deaths as of July 28, 2020, which is the highest number of cases in Southeast Asia. As restrictions in response to the pandemic continue, the public’s psychological anxiety is gradually increasing. There were 889 undergraduates and graduate students living in Indonesia or Nepal (Indonesia: 551 persons; Nepal: 338 persons). An English questionnaire was administered to participants through an online survey using Google survey. Regarding the factors affecting anxiety, they were “trust in hospitals for COVID-19 diagnosis,” “possibility of contracting COVID-19,” “concerns about family members getting COVID-19,” “national discrimination due to COVID-19,” “chronic disease status,” “experience of purchasing masks,” and “health behaviors” in Indonesia, and “trust in hospitals for COVID-19 diagnosis,” “risk of the family getting infected by COVID-19,” and “depression score” in Nepal. In both countries, significant effects of “trust in hospitals for COVID-19 diagnosis” and “risk of the family getting infected by COVID-19” were observed. Therefore, educational institutes should implement touch-free educational programs to develop social activities and prevent psychological and psychiatric issues due to the COVID-19. Other educational institutions and authorities should consider this result to develop further programs and projects.