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@article{ART002530532},
author={Kyo-Hyun Park and Bae-Hwan Kim},
title={Establishment Study of SkinEthic TM HCE eye irritation test in Korea},
journal={Journal of Alternatives to Animal Experiments},
issn={1975-9657},
year={2018},
volume={12},
number={1},
pages={1-7},
doi={10.23032/jaae.2018.12.1.004}

TY - JOUR
AU - Kyo-Hyun Park
AU - Bae-Hwan Kim
TI - Establishment Study of SkinEthic TM HCE eye irritation test in Korea
JO - Journal of Alternatives to Animal Experiments
PY - 2018
VL - 12
IS - 1
PB - Korean Society for Alternatives to Animal Experiments
SP - 1
EP - 7
SN - 1975-9657
AB - The objective of this study is to investigate the utility of reconstructed human corneal epithelium model(SkinEthic TM , HCE) as an alternative method to eye irritation test. We confirmed the pre-check test method for eye irritation test through condition setting of production for freeze-killed epidermis, possible direct MTT reduction with test substances, and colorant properties in test chemicals. And, we conducted eye irritation test using 8 chemicals listed in the proficiency test of the OECD test guideline 492. Summarizing the results above of assessment, it was confirmed that the SkinEthic TM HCE proves that it is so efficient and trustworthy enough to replace the eye irritation test. Taken together, the results indicated that the SkinEthic TM HCE proposed by OECD test guideline 492 is expected to become a well-established method in Korea.
KW - Eye irritation;SkinEthic TM;HCE;OECD test guideline 492
DO - 10.23032/jaae.2018.12.1.004
ER -

Kyo-Hyun Park and Bae-Hwan Kim. (2018). Establishment Study of SkinEthic TM HCE eye irritation test in Korea. Journal of Alternatives to Animal Experiments, 12(1), 1-7.

Kyo-Hyun Park and Bae-Hwan Kim. 2018, "Establishment Study of SkinEthic TM HCE eye irritation test in Korea", Journal of Alternatives to Animal Experiments, vol.12, no.1 pp.1-7. Available from: doi:10.23032/jaae.2018.12.1.004

Kyo-Hyun Park, Bae-Hwan Kim "Establishment Study of SkinEthic TM HCE eye irritation test in Korea" Journal of Alternatives to Animal Experiments 12.1 pp.1-7 (2018) : 1.

Kyo-Hyun Park, Bae-Hwan Kim. Establishment Study of SkinEthic TM HCE eye irritation test in Korea. 2018; 12(1), 1-7. Available from: doi:10.23032/jaae.2018.12.1.004

Kyo-Hyun Park and Bae-Hwan Kim. "Establishment Study of SkinEthic TM HCE eye irritation test in Korea" Journal of Alternatives to Animal Experiments 12, no.1 (2018) : 1-7.doi: 10.23032/jaae.2018.12.1.004

Kyo-Hyun Park; Bae-Hwan Kim. Establishment Study of SkinEthic TM HCE eye irritation test in Korea. Journal of Alternatives to Animal Experiments, 12(1), 1-7. doi: 10.23032/jaae.2018.12.1.004

Kyo-Hyun Park; Bae-Hwan Kim. Establishment Study of SkinEthic TM HCE eye irritation test in Korea. Journal of Alternatives to Animal Experiments. 2018; 12(1) 1-7. doi: 10.23032/jaae.2018.12.1.004

Kyo-Hyun Park, Bae-Hwan Kim. Establishment Study of SkinEthic TM HCE eye irritation test in Korea. 2018; 12(1), 1-7. Available from: doi:10.23032/jaae.2018.12.1.004

Kyo-Hyun Park and Bae-Hwan Kim. "Establishment Study of SkinEthic TM HCE eye irritation test in Korea" Journal of Alternatives to Animal Experiments 12, no.1 (2018) : 1-7.doi: 10.23032/jaae.2018.12.1.004