2003, Vol.15, No.1

The bibliographical Investigation of songback(松栢)

Kim Jong Dug , Song Il Byoung , Koh Byung-Hee | 2003, 15(1) | pp.1~11 | number of Cited : 2

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The Study of Chobongeun Soyangin prescription

Bae Hyo Sang , Park Seong Sik | 2003, 15(1) | pp.12~26 | number of Cited : 0

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The Study on the Upgrade of QSCC II (I) - A Study on Comparison of responses to the questionnaire based on Sasang constitution's differences-Questionnair of Sasang Constitution Classification II (QSCCII)

Taeyeon Kim , Yoo Jung Hee , Eui Ju Lee and 2 other persons | 2003, 15(1) | pp.27~38 | number of Cited : 2

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The Study on the Upgrade of QSCC II (II) - The study on the re-validity of QSCC II-

Lee Sang Gyu , Kwak Chang Kyu , Lee Eui ju and 2 other persons | 2003, 15(1) | pp.39~49 | number of Cited : 2

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A Study about five-sounds (Gong, Sang, jiao, zhi, yu) of Sasang constitutional sound analysis

Dal Rae Kim | 2003, 15(1) | pp.50~59 | number of Cited : 0

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The Effects of Medical Nutrition Therapy on Plasma Lipid Levels of Apo E3 genotype hyperlipidemic Patients according to Sasang Constitutions

Moon Bo Kyoung , Cho Mi Ran , Lee Hei Ok and 2 other persons | 2003, 15(1) | pp.60~71 | number of Cited : 2

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The purpose of this study was to investigate the effects of medical nutrition therapy(MNT) on plasma lipid levels of hyperlipidemic patients with apo E3 genotype according to Sasang Constitutions. From March to July, 2001, the 33 hyperlipidemic patients admitted to K University Medical Center were studied. The study subjects were classified according to their Sasang constitutions by QSCC II questionnaire which have been used at K University Oriental Medical Center. The anthropometric assessments, blood analysis, and apo E genetic typing were carried out. Nutrient intake was determined by food record method of food taken during two weekdays and one weekend. The MNT including the instruction for hypolipidemic and hypocholesterolemic diet (step l diet) was performed for 12 weeks. The results are as follow; (1) The mean age of hyperlipidemic patients was 49.91±8.48 years. (2) The distributions of Sasang Constitution were 60.6% of Tae-eum, 21.2% of So-yang, and 18.2% of So-eum. The distributions of apo E genotype were 6.5% of apo E2/3, 78.8% of apo E 3/3, and 15.2% of apo E 3/4. (3) The nutrient consumption of the apo E3 subjects before the MNT showed lower calorie, iron, calcium, and vitamin B2 intakes than the RDAs for each nutrients with no significant differences among the constitutions. After 12-week of MNT, only the fat consumption was decreased in the Tae-eum group. The MNT did not change the pattern of food intake. (4) The plasma level of triglyceride, total cholesterol, and LDL-C were not changed after MNT in the three constitutional groups. The level of HDL-C was significantly increased significantly in Tae-eum and So-yang group and the level of homocystein was lowered in Tae-eum group after MNT. It could be concluded that the 12-weeks MNT with hypolipidemic and hypocholesterolemic diet did not change the level of total cholesterol, triglyceride, and LDL-C effectively regardless of Sasang constitutions even though the subjects' dietary intake was improved by MNT.

Influence of Yeoldahanso-tang on the Hypoxic Damage of Cultured Cerebral Neurons from mouse and SK-N-MC cells

Soo-jung Park , Kim Hyoung-soon , Young Chun Bae and 4 other persons | 2003, 15(1) | pp.72~89 | number of Cited : 0

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To elucidate the neuroprotective effect of Yeoldahanso-tang(YHT) on nerve cells damaged by hypoxia, the cytotoxic effects of exposure to hypoxia were determined by XTT(SODIUM3,3'-{I-[(PHENYLAMINO) CARBONYL]-3,4-TETRAZOLIUM}- BIS (4-METHOXY-6-NITRO) BENZENE SULFONIC ACID HYDRATE), NR(Neutral red), MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and SRB(Sulforhodamin B) asssay. The activity of catalase and SOD(Superoxide dismutase) was measured by spectrophometry, and TNF−α(Tumor cell necrosis fector−α) and PKC(Protein kinase C) activity was measured after exposure to hypoxia and treatment of YHTWE. Also the neuroprotective effect of YHTWE was researched for the elucidatioion of neuroprotective mechanism. The results were as follows; 1. Hypoxia decreased cell viability measured by XTT, NR assay when cultured cerebral neurons were exposed to 95% N2/5% CO2 for 2∼26 minutes in these cultures and YHTWE inhibited the decrease of cell viability. 2. H2O2 treatment decreased cell viability measured by MTT, and SRB assay when cultured cerebral neurons were exposed to 1-80 μM for 6 hours, but YHTWE inhibited the decrease of cell viability. 3. Hypoxia decreased catalase and SOD activity, and also TNF−α and PKC activity in these cultured cerebral neurons, but YHTWE inhibited the decrease of the catalase and SOD activity in these cultures. 4. Hypoxia triggered the apoptosis via caspase activation and internucleosomal DNA fragmentation. Also hypoxia stimulate the release of cytochrome c forom mitochondria. YHTWE inhibited the apoptosis via caspase activation induced by hypoxia. From these results, it can be suggested that brain ischemia model induced hypoxia showed neurotoxicity on cultured mouse cerebral neurons, and the YHTWE has the neuroprotective effect in blocking the neurotoxicity induced by hypoxia in cultured mouse cerebral neurons.

Study in the Hepatoprotective Effect of Sipyimiguanjung-tang and Osuyubujaijung-tang

Lee Kyung seong , Kim Hyoung-soon , Young Chun Bae and 3 other persons | 2003, 15(1) | pp.90~108 | number of Cited : 0

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Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) has been developed as prescriptions for the Soyeumin constitution. The hepatoprotective effect of the water extract of Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) was investigated against carbon tetrachloride (CCl4)-induced hepatic damage. A single intra-peritoneal injection of CCl4 produced liver damage in rats as manifested by the significant rise of aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP) in serum as compared to those of untreated normal group. Pretreatments of rats with Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) 500 mg/kg for 7 days) were significantly reduced AST, ALT, and ALP levels compared with CCl4-treated control group. Treatment of rats with CCl4 led to significantly increase in lipid peroxidation and significantly decrease in cytochrome P450 and P450 reductase. The oral administration of Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) water extract significantly inhibited the accumulation of microsomal thiobarbituric acid reactive substance (TBARS) and increased the cytochrome P450 and P450 reductase activity. All these biochemical alterations resulting from CCl4 administration were inhibited by the pretreatment with Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SG1) extract. These results suggest that Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) water extract can be useful as a hepatoprotective agent. And the effect of NO modulation by NO synthesis or precursors, and Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang (SGT) water extract was researched on chronic liver damage induced by CCl4 administration. It was observed that endogenous NO protected the liver from lipid peroxidation, fibrosis, and damage. Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) water extract showed the hepatoprotective effect on the chronic liver cirrhosis model and relationship with NO modulation.

A Study on the analysis of constitutional genes

Han Sung Kyu , Chi， Sang-Eun , SunMi Choi | 2003, 15(1) | pp.109~117 | number of Cited : 1

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A case of Drug Eruptions of Soyangin patient misrated with Taeumin

Jeong Yong Jae , Lim Jinny , Lee Tae gyu and 3 other persons | 2003, 15(1) | pp.118~122 | number of Cited : 1

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A Case study of hydrocele

Kim Myung gune , Choi Jeong rak , Bae Hyo Sang and 1 other persons | 2003, 15(1) | pp.123~128 | number of Cited : 1

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A Case Study of heptitis on drug metabolism Impoved with Chungsimyeunjatang

Moon Byung Ha , Kim Jae Gwan | 2003, 15(1) | pp.129~132 | number of Cited : 0

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KJCKorea
Journal Central

Journal of Sasang Constitutional Medicine 2022 KCI Impact Factor : 0.87

2003, Vol.15, No.1