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@article{ART000952082},
author={고영엽 and 전제열 and 최석 and Yong Lim and 김준수 and 문현식 and 김명룡 and 조경원 and 조향훈 and Inyoub Jang},
title={Expression of bradykinin receptors and effects of bradykinin in the interstitial cells of Cajal from mouse small intestine},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2004},
volume={17},
number={4},
pages={289-295},
doi={10.11637/aba.2004.17.4.289}

TY - JOUR
AU - 고영엽
AU - 전제열
AU - 최석
AU - Yong Lim
AU - 김준수
AU - 문현식
AU - 김명룡
AU - 조경원
AU - 조향훈
AU - Inyoub Jang
TI - Expression of bradykinin receptors and effects of bradykinin in the interstitial cells of Cajal from mouse small intestine
JO - Anatomy & Biological Anthropology
PY - 2004
VL - 17
IS - 4
PB - 대한체질인류학회
SP - 289
EP - 295
SN - 2671-5651
AB - Interstitial Cells of Cajal (ICC) are pacemaker cells that generates slow waves and drive spontaneous mechanical contractions of gastrointestinal smooth muscle. Slow waves are generated the periodic activation of spontaneous inward currents (pacemaker currents). We studied the modulation of pacemaker activities by bradykinin (10-8 M) in cultured ICC with the whole cell patch-clamp technique, and the localization of bradykinin-2 receptor-immunoreactivity using double labelling immunohistochemistry in the murine small intestine. Externally applied bradykinin produced membrane depolarization in current-clamping mode. At a -70 mV of holding potential bradykinin increased tonic inward pacemaker currents. Double labelling with bradykinin-2 receptor and and c-kit was shown that ICC expressed the bradykinin-2 receptor-immunoreactivity. These results suggest that bradykinin modulates electrical activities of ICC via bradykinin-2 receptor, which may regulate gastrointestinal motility.
KW - Bradykinin;Interstitial cells of Cajal;Bradykinin receptor;Gastrointestinal motility
DO - 10.11637/aba.2004.17.4.289
ER -

고영엽, 전제열, 최석, Yong Lim, 김준수, 문현식, 김명룡, 조경원, 조향훈 and Inyoub Jang. (2004). Expression of bradykinin receptors and effects of bradykinin in the interstitial cells of Cajal from mouse small intestine. Anatomy & Biological Anthropology, 17(4), 289-295.

고영엽, 전제열, 최석, Yong Lim, 김준수, 문현식, 김명룡, 조경원, 조향훈 and Inyoub Jang. 2004, "Expression of bradykinin receptors and effects of bradykinin in the interstitial cells of Cajal from mouse small intestine", Anatomy & Biological Anthropology, vol.17, no.4 pp.289-295. Available from: doi:10.11637/aba.2004.17.4.289

고영엽, 전제열, 최석, Yong Lim, 김준수, 문현식, 김명룡, 조경원, 조향훈, Inyoub Jang "Expression of bradykinin receptors and effects of bradykinin in the interstitial cells of Cajal from mouse small intestine" Anatomy & Biological Anthropology 17.4 pp.289-295 (2004) : 289.

고영엽, 전제열, 최석, Yong Lim, 김준수, 문현식, 김명룡, 조경원, 조향훈, Inyoub Jang. Expression of bradykinin receptors and effects of bradykinin in the interstitial cells of Cajal from mouse small intestine. 2004; 17(4), 289-295. Available from: doi:10.11637/aba.2004.17.4.289

고영엽, 전제열, 최석, Yong Lim, 김준수, 문현식, 김명룡, 조경원, 조향훈 and Inyoub Jang. "Expression of bradykinin receptors and effects of bradykinin in the interstitial cells of Cajal from mouse small intestine" Anatomy & Biological Anthropology 17, no.4 (2004) : 289-295.doi: 10.11637/aba.2004.17.4.289

고영엽; 전제열; 최석; Yong Lim; 김준수; 문현식; 김명룡; 조경원; 조향훈; Inyoub Jang. Expression of bradykinin receptors and effects of bradykinin in the interstitial cells of Cajal from mouse small intestine. Anatomy & Biological Anthropology, 17(4), 289-295. doi: 10.11637/aba.2004.17.4.289

고영엽; 전제열; 최석; Yong Lim; 김준수; 문현식; 김명룡; 조경원; 조향훈; Inyoub Jang. Expression of bradykinin receptors and effects of bradykinin in the interstitial cells of Cajal from mouse small intestine. Anatomy & Biological Anthropology. 2004; 17(4) 289-295. doi: 10.11637/aba.2004.17.4.289

고영엽, 전제열, 최석, Yong Lim, 김준수, 문현식, 김명룡, 조경원, 조향훈, Inyoub Jang. Expression of bradykinin receptors and effects of bradykinin in the interstitial cells of Cajal from mouse small intestine. 2004; 17(4), 289-295. Available from: doi:10.11637/aba.2004.17.4.289

고영엽, 전제열, 최석, Yong Lim, 김준수, 문현식, 김명룡, 조경원, 조향훈 and Inyoub Jang. "Expression of bradykinin receptors and effects of bradykinin in the interstitial cells of Cajal from mouse small intestine" Anatomy & Biological Anthropology 17, no.4 (2004) : 289-295.doi: 10.11637/aba.2004.17.4.289