@article{ART001144108},
author={손동섭 and 이희상 and 김대진 and 최형택 and 이금정 and 조혜진 and 김석중 and Jongchan Lee and 정윤희 and Sung Su Kim and Lee Won Bok and 김경용},
title={Oxidative stress induced-expression changes of zonular occludens-1 in thight junction},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2004},
volume={17},
number={4},
pages={281-288},
doi={10.11637/aba.2004.17.4.281}
TY - JOUR
AU - 손동섭
AU - 이희상
AU - 김대진
AU - 최형택
AU - 이금정
AU - 조혜진
AU - 김석중
AU - Jongchan Lee
AU - 정윤희
AU - Sung Su Kim
AU - Lee Won Bok
AU - 김경용
TI - Oxidative stress induced-expression changes of zonular occludens-1 in thight junction
JO - Anatomy & Biological Anthropology
PY - 2004
VL - 17
IS - 4
PB - 대한체질인류학회
SP - 281
EP - 288
SN - 2671-5651
AB - The homeostasis of microenvironment in central nervous system, essential for normal function, is maintained by
blood-brain barrier (BBB). ZO-1 in tight junctions (TJs) plays an important role in maintaining BBB endothelial ion
and solute barriers. Malfunction of BBB by reactive oxygen species has been attributed to disruption of TJs. This study
examined H2O2 effects on paracellular permeability and changes in TJ protein ZO-1 using primary culture of bovine
brain microvessel endothelial cells.
The BBB permeability,measured as TER, increased in a dose-and time-dependent manner when treated with H2O2
(0.01, 0.1, 1.0 mM). Cytotoxicity test revealed that H2O2 did not cause cell death below 1 mM H2O2 within 4 hr. H2O2
caused intermittent disruption and loss of ZO-1 at tight junctions, but ZO-1 maintained steady state levels of
expression. In conclusion, we report that H2O2 induces increased paracellular permeability of BBB that is accompanied
with alterations in localization of ZO-1.
KW - Oxidative stress;Blood-brain barrier;Tight junction;ZO-1
DO - 10.11637/aba.2004.17.4.281
ER -
손동섭, 이희상, 김대진, 최형택, 이금정, 조혜진, 김석중, Jongchan Lee, 정윤희, Sung Su Kim, Lee Won Bok and 김경용. (2004). Oxidative stress induced-expression changes of zonular occludens-1 in thight junction. Anatomy & Biological Anthropology, 17(4), 281-288.
손동섭, 이희상, 김대진, 최형택, 이금정, 조혜진, 김석중, Jongchan Lee, 정윤희, Sung Su Kim, Lee Won Bok and 김경용. 2004, "Oxidative stress induced-expression changes of zonular occludens-1 in thight junction", Anatomy & Biological Anthropology, vol.17, no.4 pp.281-288. Available from: doi:10.11637/aba.2004.17.4.281
손동섭, 이희상, 김대진, 최형택, 이금정, 조혜진, 김석중, Jongchan Lee, 정윤희, Sung Su Kim, Lee Won Bok, 김경용 "Oxidative stress induced-expression changes of zonular occludens-1 in thight junction" Anatomy & Biological Anthropology 17.4 pp.281-288 (2004) : 281.
손동섭, 이희상, 김대진, 최형택, 이금정, 조혜진, 김석중, Jongchan Lee, 정윤희, Sung Su Kim, Lee Won Bok, 김경용. Oxidative stress induced-expression changes of zonular occludens-1 in thight junction. 2004; 17(4), 281-288. Available from: doi:10.11637/aba.2004.17.4.281
손동섭, 이희상, 김대진, 최형택, 이금정, 조혜진, 김석중, Jongchan Lee, 정윤희, Sung Su Kim, Lee Won Bok and 김경용. "Oxidative stress induced-expression changes of zonular occludens-1 in thight junction" Anatomy & Biological Anthropology 17, no.4 (2004) : 281-288.doi: 10.11637/aba.2004.17.4.281
손동섭; 이희상; 김대진; 최형택; 이금정; 조혜진; 김석중; Jongchan Lee; 정윤희; Sung Su Kim; Lee Won Bok; 김경용. Oxidative stress induced-expression changes of zonular occludens-1 in thight junction. Anatomy & Biological Anthropology, 17(4), 281-288. doi: 10.11637/aba.2004.17.4.281
손동섭; 이희상; 김대진; 최형택; 이금정; 조혜진; 김석중; Jongchan Lee; 정윤희; Sung Su Kim; Lee Won Bok; 김경용. Oxidative stress induced-expression changes of zonular occludens-1 in thight junction. Anatomy & Biological Anthropology. 2004; 17(4) 281-288. doi: 10.11637/aba.2004.17.4.281
손동섭, 이희상, 김대진, 최형택, 이금정, 조혜진, 김석중, Jongchan Lee, 정윤희, Sung Su Kim, Lee Won Bok, 김경용. Oxidative stress induced-expression changes of zonular occludens-1 in thight junction. 2004; 17(4), 281-288. Available from: doi:10.11637/aba.2004.17.4.281
손동섭, 이희상, 김대진, 최형택, 이금정, 조혜진, 김석중, Jongchan Lee, 정윤희, Sung Su Kim, Lee Won Bok and 김경용. "Oxidative stress induced-expression changes of zonular occludens-1 in thight junction" Anatomy & Biological Anthropology 17, no.4 (2004) : 281-288.doi: 10.11637/aba.2004.17.4.281
