@article{ART000952118},
author={KIM,GYOO-CHEON and 황윤 and 박재현 and 문용석 and Young Hyun Yoo and Shin Sanghun and Kyung-Il Um and PARK,BONG SOO},
title={Characteristics of mitochondrial events in synthetic bile acids-induced apoptosis of human osteosarcoma cells},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2004},
volume={17},
number={4},
pages={351-362},
doi={10.11637/aba.2004.17.4.351}
TY - JOUR
AU - KIM,GYOO-CHEON
AU - 황윤
AU - 박재현
AU - 문용석
AU - Young Hyun Yoo
AU - Shin Sanghun
AU - Kyung-Il Um
AU - PARK,BONG SOO
TI - Characteristics of mitochondrial events in synthetic bile acids-induced apoptosis of human osteosarcoma cells
JO - Anatomy & Biological Anthropology
PY - 2004
VL - 17
IS - 4
PB - 대한체질인류학회
SP - 351
EP - 362
SN - 2671-5651
AB - Apoptosis of osteosarcoma cells induced by bile duct derivates, HS-1200 was investigated with relation to
mitochodria. HS-1200 induced cytochrome c and Smac/DIABLO release from mitochondria which are major factors
related to apoptosis. In these apoptosis processes, release of cytochrome c was not blocked by caspase inhibitor, but
release of Smac/DIABLO was blocked. BKA, a kind of PTP (permeablity transition pore) inhibitor, did not block both
of them. Interestingly, the alteration of MMP was not observed by means of using JC-1 dye. Although MitoTracker,
DiOC-6 and Rhodamine123 were used to confirm previous results, the decrease of MMP was not observed. In order to
investigate whether this phenomenon is apoptosis-specific or cell-specific process, genistein was added to cells which
usually decreased MMP. After adding genistein, MMP was not decreased, suggesting this phenomenon is cell-specific
process.
Conclusionally, HS-1200 induced apoptosis of osteosarcoma cells via mitochondria, cytochrome c and Smac/
DIABLO were released from mitochondria without decrease of MMP. The release of Smac/DIABLO was dependent of
caspase.
KW - Bile duct derivates;Apoptosis;MMP;Osteosarcoma cells
DO - 10.11637/aba.2004.17.4.351
ER -
KIM,GYOO-CHEON, 황윤, 박재현, 문용석, Young Hyun Yoo, Shin Sanghun, Kyung-Il Um and PARK,BONG SOO. (2004). Characteristics of mitochondrial events in synthetic bile acids-induced apoptosis of human osteosarcoma cells. Anatomy & Biological Anthropology, 17(4), 351-362.
KIM,GYOO-CHEON, 황윤, 박재현, 문용석, Young Hyun Yoo, Shin Sanghun, Kyung-Il Um and PARK,BONG SOO. 2004, "Characteristics of mitochondrial events in synthetic bile acids-induced apoptosis of human osteosarcoma cells", Anatomy & Biological Anthropology, vol.17, no.4 pp.351-362. Available from: doi:10.11637/aba.2004.17.4.351
KIM,GYOO-CHEON, 황윤, 박재현, 문용석, Young Hyun Yoo, Shin Sanghun, Kyung-Il Um, PARK,BONG SOO "Characteristics of mitochondrial events in synthetic bile acids-induced apoptosis of human osteosarcoma cells" Anatomy & Biological Anthropology 17.4 pp.351-362 (2004) : 351.
KIM,GYOO-CHEON, 황윤, 박재현, 문용석, Young Hyun Yoo, Shin Sanghun, Kyung-Il Um, PARK,BONG SOO. Characteristics of mitochondrial events in synthetic bile acids-induced apoptosis of human osteosarcoma cells. 2004; 17(4), 351-362. Available from: doi:10.11637/aba.2004.17.4.351
KIM,GYOO-CHEON, 황윤, 박재현, 문용석, Young Hyun Yoo, Shin Sanghun, Kyung-Il Um and PARK,BONG SOO. "Characteristics of mitochondrial events in synthetic bile acids-induced apoptosis of human osteosarcoma cells" Anatomy & Biological Anthropology 17, no.4 (2004) : 351-362.doi: 10.11637/aba.2004.17.4.351
KIM,GYOO-CHEON; 황윤; 박재현; 문용석; Young Hyun Yoo; Shin Sanghun; Kyung-Il Um; PARK,BONG SOO. Characteristics of mitochondrial events in synthetic bile acids-induced apoptosis of human osteosarcoma cells. Anatomy & Biological Anthropology, 17(4), 351-362. doi: 10.11637/aba.2004.17.4.351
KIM,GYOO-CHEON; 황윤; 박재현; 문용석; Young Hyun Yoo; Shin Sanghun; Kyung-Il Um; PARK,BONG SOO. Characteristics of mitochondrial events in synthetic bile acids-induced apoptosis of human osteosarcoma cells. Anatomy & Biological Anthropology. 2004; 17(4) 351-362. doi: 10.11637/aba.2004.17.4.351
KIM,GYOO-CHEON, 황윤, 박재현, 문용석, Young Hyun Yoo, Shin Sanghun, Kyung-Il Um, PARK,BONG SOO. Characteristics of mitochondrial events in synthetic bile acids-induced apoptosis of human osteosarcoma cells. 2004; 17(4), 351-362. Available from: doi:10.11637/aba.2004.17.4.351
KIM,GYOO-CHEON, 황윤, 박재현, 문용석, Young Hyun Yoo, Shin Sanghun, Kyung-Il Um and PARK,BONG SOO. "Characteristics of mitochondrial events in synthetic bile acids-induced apoptosis of human osteosarcoma cells" Anatomy & Biological Anthropology 17, no.4 (2004) : 351-362.doi: 10.11637/aba.2004.17.4.351
