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@article{ART000952373},
author={이남섭 and 김기형 and 김철태 and 고경옥 and Kim Se Hoon and Park Hyung Seo and 정영길},
title={Abnormal expression of neuropeptide Y in the cerebellar Purkinje cells of the ataxic mutant mice, Pogo},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2004},
volume={17},
number={2},
pages={153-161},
doi={10.11637/aba.2004.17.2.153}

TY - JOUR
AU - 이남섭
AU - 김기형
AU - 김철태
AU - 고경옥
AU - Kim Se Hoon
AU - Park Hyung Seo
AU - 정영길
TI - Abnormal expression of neuropeptide Y in the cerebellar Purkinje cells of the ataxic mutant mice, Pogo
JO - Anatomy & Biological Anthropology
PY - 2004
VL - 17
IS - 2
PB - 대한체질인류학회
SP - 153
EP - 161
SN - 2671-5651
AB - The pogo mouse is an autosomal recessive ataxic mutant that arose spontaneously in the inbred KJR/MsKist strain derived originally from Korean wild mice. The ataxic phenotype is characterized by difficulty in maintaining posture and the consequent inability to walk straight. In our previous study about pogo mice cerebellum, we reported the Purkinje cell abnormalities and ectopic expression of tyrosine hydroxylase (TH) in Purkinje cell. In this study, we have provided an abnormal expression of NPY in ataxic mutant pogo mice for the first time. There was increased immunoreactivity for NPY in Purkinje cell of ataxic pogo (pogo/pogo) mice compared to those of heterozygote non-ataxic pogo mice (pogo/±, control group). In our previous study, TH is also expressed abnormally in Purkinje cells of ataxic mutant pogo (pogo/pogo) mouse cerebellum. To compare the expression patterns of TH and NPY within some Purkinje cell using double immunofluorescence, most of NPY-immunoreactive Purkinje cells in the ataxic pogo mice are TH-immunoreactive Purkinje cells. However, all of TH-immunoreactive Purkinje cells are not express the NPY. These data reveal that abnormal NPY-immunoreactivity in the ataxic pogo (pogo/pogo) cerebellum is restricted to a subset of cells within the ectopic TH-immunoreactive Purkinje cell subset. These results further suggest that Purkinje cell abnormalities contribute to motor ataxia in the ataxic pogo mouse.
KW - Pogo mouse;Cerebellum;NPY;Tyrosine Hydroxylase;Purkinje cell
DO - 10.11637/aba.2004.17.2.153
ER -

이남섭, 김기형, 김철태, 고경옥, Kim Se Hoon, Park Hyung Seo and 정영길. (2004). Abnormal expression of neuropeptide Y in the cerebellar Purkinje cells of the ataxic mutant mice, Pogo. Anatomy & Biological Anthropology, 17(2), 153-161.

이남섭, 김기형, 김철태, 고경옥, Kim Se Hoon, Park Hyung Seo and 정영길. 2004, "Abnormal expression of neuropeptide Y in the cerebellar Purkinje cells of the ataxic mutant mice, Pogo", Anatomy & Biological Anthropology, vol.17, no.2 pp.153-161. Available from: doi:10.11637/aba.2004.17.2.153

이남섭, 김기형, 김철태, 고경옥, Kim Se Hoon, Park Hyung Seo, 정영길 "Abnormal expression of neuropeptide Y in the cerebellar Purkinje cells of the ataxic mutant mice, Pogo" Anatomy & Biological Anthropology 17.2 pp.153-161 (2004) : 153.

이남섭, 김기형, 김철태, 고경옥, Kim Se Hoon, Park Hyung Seo, 정영길. Abnormal expression of neuropeptide Y in the cerebellar Purkinje cells of the ataxic mutant mice, Pogo. 2004; 17(2), 153-161. Available from: doi:10.11637/aba.2004.17.2.153

이남섭, 김기형, 김철태, 고경옥, Kim Se Hoon, Park Hyung Seo and 정영길. "Abnormal expression of neuropeptide Y in the cerebellar Purkinje cells of the ataxic mutant mice, Pogo" Anatomy & Biological Anthropology 17, no.2 (2004) : 153-161.doi: 10.11637/aba.2004.17.2.153

이남섭; 김기형; 김철태; 고경옥; Kim Se Hoon; Park Hyung Seo; 정영길. Abnormal expression of neuropeptide Y in the cerebellar Purkinje cells of the ataxic mutant mice, Pogo. Anatomy & Biological Anthropology, 17(2), 153-161. doi: 10.11637/aba.2004.17.2.153

이남섭; 김기형; 김철태; 고경옥; Kim Se Hoon; Park Hyung Seo; 정영길. Abnormal expression of neuropeptide Y in the cerebellar Purkinje cells of the ataxic mutant mice, Pogo. Anatomy & Biological Anthropology. 2004; 17(2) 153-161. doi: 10.11637/aba.2004.17.2.153

이남섭, 김기형, 김철태, 고경옥, Kim Se Hoon, Park Hyung Seo, 정영길. Abnormal expression of neuropeptide Y in the cerebellar Purkinje cells of the ataxic mutant mice, Pogo. 2004; 17(2), 153-161. Available from: doi:10.11637/aba.2004.17.2.153

이남섭, 김기형, 김철태, 고경옥, Kim Se Hoon, Park Hyung Seo and 정영길. "Abnormal expression of neuropeptide Y in the cerebellar Purkinje cells of the ataxic mutant mice, Pogo" Anatomy & Biological Anthropology 17, no.2 (2004) : 153-161.doi: 10.11637/aba.2004.17.2.153