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@article{ART001064992},
author={김승오 and 김민경 and 서동현 and 김찬웅 and 조승묵 and 한장희 and 박정현 and 박경한 and 김대중},
title={Tissue Transglutaminase Activates NF-κB Pathway in the Atherosclerotic Coronary Artery},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2007},
volume={20},
number={2},
pages={83-92},
doi={10.11637/aba.2007.20.2.83}

TY - JOUR
AU - 김승오
AU - 김민경
AU - 서동현
AU - 김찬웅
AU - 조승묵
AU - 한장희
AU - 박정현
AU - 박경한
AU - 김대중
TI - Tissue Transglutaminase Activates NF-κB Pathway in the Atherosclerotic Coronary Artery
JO - Anatomy & Biological Anthropology
PY - 2007
VL - 20
IS - 2
PB - 대한체질인류학회
SP - 83
EP - 92
SN - 2671-5651
AB - Molecular mechanism of nuclear factor-κB(NF-κB) in the atherosclerosis has been unclear. Recently, NF-κB activating function of tissue transglutaminase (tTGase), multifunctional calcium-dependent transamidation enzyme, have been reported in the various tissues like neuroglia. In this report, we investigated the immunoreactivity of tTGase at the human atherosclerotic coronary artery, and examined the effect of tTGase on the well-known proatherogenic NF-κB pathway using tTGase-overexpressed cells. Immunohistochemical studies on autopsy samples showed that immunoreactivity of tTGase was markedly elevated in the neointimal tissues of atherosclerotic coronary arteries with progression of disease. Immunohistochemical staining also demonstrated that phosphorylated I-κB was activated in the atherosclerotic vessel wall. In vitro study using rat cardiomyoblast (H9c2) and tTGase-overexpressed H9c2 showed that activated tTGase enhanced the phosphorylation of I-κB, and this activation was inhibited by tTGase specific inhibitors. These findings suggest that cytosolic tTGase may serve as an activator of NF-κB.
KW - Tissue transglutaminase;NF-κB;Atherosclerosis;Coronary artery
DO - 10.11637/aba.2007.20.2.83
ER -

김승오, 김민경, 서동현, 김찬웅, 조승묵, 한장희, 박정현, 박경한 and 김대중. (2007). Tissue Transglutaminase Activates NF-κB Pathway in the Atherosclerotic Coronary Artery. Anatomy & Biological Anthropology, 20(2), 83-92.

김승오, 김민경, 서동현, 김찬웅, 조승묵, 한장희, 박정현, 박경한 and 김대중. 2007, "Tissue Transglutaminase Activates NF-κB Pathway in the Atherosclerotic Coronary Artery", Anatomy & Biological Anthropology, vol.20, no.2 pp.83-92. Available from: doi:10.11637/aba.2007.20.2.83

김승오, 김민경, 서동현, 김찬웅, 조승묵, 한장희, 박정현, 박경한, 김대중 "Tissue Transglutaminase Activates NF-κB Pathway in the Atherosclerotic Coronary Artery" Anatomy & Biological Anthropology 20.2 pp.83-92 (2007) : 83.

김승오, 김민경, 서동현, 김찬웅, 조승묵, 한장희, 박정현, 박경한, 김대중. Tissue Transglutaminase Activates NF-κB Pathway in the Atherosclerotic Coronary Artery. 2007; 20(2), 83-92. Available from: doi:10.11637/aba.2007.20.2.83

김승오, 김민경, 서동현, 김찬웅, 조승묵, 한장희, 박정현, 박경한 and 김대중. "Tissue Transglutaminase Activates NF-κB Pathway in the Atherosclerotic Coronary Artery" Anatomy & Biological Anthropology 20, no.2 (2007) : 83-92.doi: 10.11637/aba.2007.20.2.83

김승오; 김민경; 서동현; 김찬웅; 조승묵; 한장희; 박정현; 박경한; 김대중. Tissue Transglutaminase Activates NF-κB Pathway in the Atherosclerotic Coronary Artery. Anatomy & Biological Anthropology, 20(2), 83-92. doi: 10.11637/aba.2007.20.2.83

김승오; 김민경; 서동현; 김찬웅; 조승묵; 한장희; 박정현; 박경한; 김대중. Tissue Transglutaminase Activates NF-κB Pathway in the Atherosclerotic Coronary Artery. Anatomy & Biological Anthropology. 2007; 20(2) 83-92. doi: 10.11637/aba.2007.20.2.83

김승오, 김민경, 서동현, 김찬웅, 조승묵, 한장희, 박정현, 박경한, 김대중. Tissue Transglutaminase Activates NF-κB Pathway in the Atherosclerotic Coronary Artery. 2007; 20(2), 83-92. Available from: doi:10.11637/aba.2007.20.2.83

김승오, 김민경, 서동현, 김찬웅, 조승묵, 한장희, 박정현, 박경한 and 김대중. "Tissue Transglutaminase Activates NF-κB Pathway in the Atherosclerotic Coronary Artery" Anatomy & Biological Anthropology 20, no.2 (2007) : 83-92.doi: 10.11637/aba.2007.20.2.83