@article{ART001064994},
author={이수복},
title={Trinucleotide Repeat Polymorphisms of Spinal and Bulbar Muscular Atrophy (SBMA) Gene in Asian Populations},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2007},
volume={20},
number={2},
pages={127-135},
doi={10.11637/aba.2007.20.2.127}
TY - JOUR
AU - 이수복
TI - Trinucleotide Repeat Polymorphisms of Spinal and Bulbar Muscular Atrophy (SBMA) Gene in Asian Populations
JO - Anatomy & Biological Anthropology
PY - 2007
VL - 20
IS - 2
PB - 대한체질인류학회
SP - 127
EP - 135
SN - 2671-5651
AB - I previously reported the PCR-based Spinal and bulbar muscular atrophy (SBMA) region polymorphisms in the three
northeast Asian populations (Chinese, Koreans, Japanese) and Caucasians. Here I update this analysis by including the
data of the allele distribution in 378 unrelated individuals from four populations in Asia.
In this study I investigated PCR-based CAG repeat polymorphism on the SBMA locus among four Asian populations
(Mongolian, Evenki, Orochon, Negrito) and performed the statistical analysis on the eight populations including the
previously analyzed data.
Both statistical analyses of one-way ANOVA (F=3.284, P=0.002) and Kruskal-Wallis test (χ2=21.542, DF=7, P=
0.003) showed remarkable differences in CAG allele distributions among the populations. Post-hoc test showed that the
difference between Negritos and Caucasians was especially significant (Scheffe: P=0.042; Bonferroni: P=0.004). Also
a significant differences among Northeast Asians, Caucasians and Negritos (Southeast Asian) were detected by these
two tests (ANOVA; F=8.132, P⁄0.000, Kruskal-Wallis; χ2=16.614, DF=2, P⁄0.000). Post-hoc test showed that the
differences between Negritos and Caucasias was also especially significant (Scheffe: P=0.001; Bonferroni: P=0.000)
among these three groups.
These data present that the CAG repeat polymorphism of SBMA gene has a useful information for studies of human
population genetics.
KW - Spinal and bulbar muscular atrophy (SBMA);Androgen receptor (AR);CAG trinucleotide repeat polymorphisms;
Northeast Asian
DO - 10.11637/aba.2007.20.2.127
ER -
이수복. (2007). Trinucleotide Repeat Polymorphisms of Spinal and Bulbar Muscular Atrophy (SBMA) Gene in Asian Populations. Anatomy & Biological Anthropology, 20(2), 127-135.
이수복. 2007, "Trinucleotide Repeat Polymorphisms of Spinal and Bulbar Muscular Atrophy (SBMA) Gene in Asian Populations", Anatomy & Biological Anthropology, vol.20, no.2 pp.127-135. Available from: doi:10.11637/aba.2007.20.2.127
이수복 "Trinucleotide Repeat Polymorphisms of Spinal and Bulbar Muscular Atrophy (SBMA) Gene in Asian Populations" Anatomy & Biological Anthropology 20.2 pp.127-135 (2007) : 127.
이수복. Trinucleotide Repeat Polymorphisms of Spinal and Bulbar Muscular Atrophy (SBMA) Gene in Asian Populations. 2007; 20(2), 127-135. Available from: doi:10.11637/aba.2007.20.2.127
이수복. "Trinucleotide Repeat Polymorphisms of Spinal and Bulbar Muscular Atrophy (SBMA) Gene in Asian Populations" Anatomy & Biological Anthropology 20, no.2 (2007) : 127-135.doi: 10.11637/aba.2007.20.2.127
이수복. Trinucleotide Repeat Polymorphisms of Spinal and Bulbar Muscular Atrophy (SBMA) Gene in Asian Populations. Anatomy & Biological Anthropology, 20(2), 127-135. doi: 10.11637/aba.2007.20.2.127
이수복. Trinucleotide Repeat Polymorphisms of Spinal and Bulbar Muscular Atrophy (SBMA) Gene in Asian Populations. Anatomy & Biological Anthropology. 2007; 20(2) 127-135. doi: 10.11637/aba.2007.20.2.127
이수복. Trinucleotide Repeat Polymorphisms of Spinal and Bulbar Muscular Atrophy (SBMA) Gene in Asian Populations. 2007; 20(2), 127-135. Available from: doi:10.11637/aba.2007.20.2.127
이수복. "Trinucleotide Repeat Polymorphisms of Spinal and Bulbar Muscular Atrophy (SBMA) Gene in Asian Populations" Anatomy & Biological Anthropology 20, no.2 (2007) : 127-135.doi: 10.11637/aba.2007.20.2.127
