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@article{ART001143036},
author={박영란 and 정윤영 and 천관영 and 박근용 and 설경수 and 김종중 and 문정석},
title={Morphological Changes in Vasopressin- immunoreactive Neurons in the Hypothalamus of the Aged Rats},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2007},
volume={20},
number={1},
pages={35-43},
doi={10.11637/aba.2007.20.1.35}

TY - JOUR
AU - 박영란
AU - 정윤영
AU - 천관영
AU - 박근용
AU - 설경수
AU - 김종중
AU - 문정석
TI - Morphological Changes in Vasopressin- immunoreactive Neurons in the Hypothalamus of the Aged Rats
JO - Anatomy & Biological Anthropology
PY - 2007
VL - 20
IS - 1
PB - 대한체질인류학회
SP - 35
EP - 43
SN - 2671-5651
AB - The role of neuropeptides in the central nervous system (CNS) has received increasing attention. Numerous peptide molecules are found in the mammalian CNS and many of them are thought to act as either neurotransmitters or neuromodulators. The neuropeptides found in high concentration in the hypothalamus include vasopressin (VP), vasoactive intestinal polypeptide, somatostatin, and oxytocin. The main approches to assess the involvement of neuropeptides can be focused on functions affecting the aging of the brain. Morphological aging of the CNS has been characterized by degenerative changes of fiber connections and cell loss, although degeneration does not always occur to the same extent throughout various parts of the brain and, moreover, varies for different cell types. Despite of many studies in VP containing neurons , there exist discrepancies in results about the changes of aged rat brain. The aim of the present study is, therefore, to investigative possible changes in the number and morphology of VPimmunoreactive neurons with aging in each area of the hypothalmus of the aged rats. As a result, the number of VP-immunoreactive neurons was decreased in hypothalamus nucleus of aged group. Especially, in VP-immunoreactive neurons of hypothalamus, the size of neuronal cell body and nuclei in aged group is larger than in young group and the fiber density of immunoreactivity neurons of median eminance (ME) in aged group is stronger than in young group. But, the total number of VP-immunoreactive neurons in the suprachiasmatic nucleus (SCN) of the aged group is larger than in the young group. These studies indicate the involvement of VP-immunoreactive neurons in aging process of hypothalamus, and aging process may affect the synthesis of VP in the neurons of hypothalamic nuclei. Whereas, in VP expression, aging process induces an enlargement of the cell size of surviving neurons to compensate.
KW - Aging;Vasopressin;Supraoptic nucleus;Paraventricular nucleus;Suprachiasmatic nucleus
DO - 10.11637/aba.2007.20.1.35
ER -

박영란, 정윤영, 천관영, 박근용, 설경수, 김종중 and 문정석. (2007). Morphological Changes in Vasopressin- immunoreactive Neurons in the Hypothalamus of the Aged Rats. Anatomy & Biological Anthropology, 20(1), 35-43.

박영란, 정윤영, 천관영, 박근용, 설경수, 김종중 and 문정석. 2007, "Morphological Changes in Vasopressin- immunoreactive Neurons in the Hypothalamus of the Aged Rats", Anatomy & Biological Anthropology, vol.20, no.1 pp.35-43. Available from: doi:10.11637/aba.2007.20.1.35

박영란, 정윤영, 천관영, 박근용, 설경수, 김종중, 문정석 "Morphological Changes in Vasopressin- immunoreactive Neurons in the Hypothalamus of the Aged Rats" Anatomy & Biological Anthropology 20.1 pp.35-43 (2007) : 35.

박영란, 정윤영, 천관영, 박근용, 설경수, 김종중, 문정석. Morphological Changes in Vasopressin- immunoreactive Neurons in the Hypothalamus of the Aged Rats. 2007; 20(1), 35-43. Available from: doi:10.11637/aba.2007.20.1.35

박영란, 정윤영, 천관영, 박근용, 설경수, 김종중 and 문정석. "Morphological Changes in Vasopressin- immunoreactive Neurons in the Hypothalamus of the Aged Rats" Anatomy & Biological Anthropology 20, no.1 (2007) : 35-43.doi: 10.11637/aba.2007.20.1.35

박영란; 정윤영; 천관영; 박근용; 설경수; 김종중; 문정석. Morphological Changes in Vasopressin- immunoreactive Neurons in the Hypothalamus of the Aged Rats. Anatomy & Biological Anthropology, 20(1), 35-43. doi: 10.11637/aba.2007.20.1.35

박영란; 정윤영; 천관영; 박근용; 설경수; 김종중; 문정석. Morphological Changes in Vasopressin- immunoreactive Neurons in the Hypothalamus of the Aged Rats. Anatomy & Biological Anthropology. 2007; 20(1) 35-43. doi: 10.11637/aba.2007.20.1.35

박영란, 정윤영, 천관영, 박근용, 설경수, 김종중, 문정석. Morphological Changes in Vasopressin- immunoreactive Neurons in the Hypothalamus of the Aged Rats. 2007; 20(1), 35-43. Available from: doi:10.11637/aba.2007.20.1.35

박영란, 정윤영, 천관영, 박근용, 설경수, 김종중 and 문정석. "Morphological Changes in Vasopressin- immunoreactive Neurons in the Hypothalamus of the Aged Rats" Anatomy & Biological Anthropology 20, no.1 (2007) : 35-43.doi: 10.11637/aba.2007.20.1.35