KJCKorea
Journal Central

@article{ART001143350},
author={임진수 and Seog-Ki Lee and 장인엽 and 하현철 and 임 용 and 김한용 and 박경한 and 윤상필},
title={Activation of Macrophage by Polysaccharide Isolated from Salicornia herbacea L.},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2006},
volume={19},
number={2},
pages={117-124},
doi={10.11637/aba.2006.19.2.117}

TY - JOUR
AU - 임진수
AU - Seog-Ki Lee
AU - 장인엽
AU - 하현철
AU - 임 용
AU - 김한용
AU - 박경한
AU - 윤상필
TI - Activation of Macrophage by Polysaccharide Isolated from Salicornia herbacea L.
JO - Anatomy & Biological Anthropology
PY - 2006
VL - 19
IS - 2
PB - 대한체질인류학회
SP - 117
EP - 124
SN - 2671-5651
AB - Salicornia herbacea L. is one of the halophytes that can grow in salt marshes, or salt fields along the seashores in Korea. The objective of this study is to investigate the mechanism by which Salicornia Polysaccharide, (SPS) activates macrophages. To analyze macrophage activation and iNOS gene expression, we performed nitrite generation assay, immunohistochemistry, and reverse transcriptase-polymerase chain reaction. A polysaccharide isolated from the Salicornia herbacea L. significantly induces nitric oxide (NO). Immunohistochemical staining of inducible NO synthase (iNOS) showed that the increase of NO was due to the induction of iNOS production. RT-PCR analysis showed that SPS produced significant induction of iNOS gene expression. Immunohistochemical staining of p65 showed that SPS produced strong induction of NF-κB/Rel nuclear translocation. Electrophoretic mobility shift assay further confirmed the activation of NF-κB/Rel by SPS. In conclusion, we demonstrate that SPS stimulates the macrophages to express iNOS gene via the activation of NF-κB/Rel.
KW - Salicornia herbacea L.;Macrophages;iNOS
DO - 10.11637/aba.2006.19.2.117
ER -

임진수, Seog-Ki Lee, 장인엽, 하현철, 임 용, 김한용, 박경한 and 윤상필. (2006). Activation of Macrophage by Polysaccharide Isolated from Salicornia herbacea L.. Anatomy & Biological Anthropology, 19(2), 117-124.

임진수, Seog-Ki Lee, 장인엽, 하현철, 임 용, 김한용, 박경한 and 윤상필. 2006, "Activation of Macrophage by Polysaccharide Isolated from Salicornia herbacea L.", Anatomy & Biological Anthropology, vol.19, no.2 pp.117-124. Available from: doi:10.11637/aba.2006.19.2.117

임진수, Seog-Ki Lee, 장인엽, 하현철, 임 용, 김한용, 박경한, 윤상필 "Activation of Macrophage by Polysaccharide Isolated from Salicornia herbacea L." Anatomy & Biological Anthropology 19.2 pp.117-124 (2006) : 117.

임진수, Seog-Ki Lee, 장인엽, 하현철, 임 용, 김한용, 박경한, 윤상필. Activation of Macrophage by Polysaccharide Isolated from Salicornia herbacea L.. 2006; 19(2), 117-124. Available from: doi:10.11637/aba.2006.19.2.117

임진수, Seog-Ki Lee, 장인엽, 하현철, 임 용, 김한용, 박경한 and 윤상필. "Activation of Macrophage by Polysaccharide Isolated from Salicornia herbacea L." Anatomy & Biological Anthropology 19, no.2 (2006) : 117-124.doi: 10.11637/aba.2006.19.2.117

임진수; Seog-Ki Lee; 장인엽; 하현철; 임 용; 김한용; 박경한; 윤상필. Activation of Macrophage by Polysaccharide Isolated from Salicornia herbacea L.. Anatomy & Biological Anthropology, 19(2), 117-124. doi: 10.11637/aba.2006.19.2.117

임진수; Seog-Ki Lee; 장인엽; 하현철; 임 용; 김한용; 박경한; 윤상필. Activation of Macrophage by Polysaccharide Isolated from Salicornia herbacea L.. Anatomy & Biological Anthropology. 2006; 19(2) 117-124. doi: 10.11637/aba.2006.19.2.117

임진수, Seog-Ki Lee, 장인엽, 하현철, 임 용, 김한용, 박경한, 윤상필. Activation of Macrophage by Polysaccharide Isolated from Salicornia herbacea L.. 2006; 19(2), 117-124. Available from: doi:10.11637/aba.2006.19.2.117

임진수, Seog-Ki Lee, 장인엽, 하현철, 임 용, 김한용, 박경한 and 윤상필. "Activation of Macrophage by Polysaccharide Isolated from Salicornia herbacea L." Anatomy & Biological Anthropology 19, no.2 (2006) : 117-124.doi: 10.11637/aba.2006.19.2.117