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@article{ART001143893},
author={이도연 and Sung Su Kim and 김경용 and Lee Won Bok and 김대경 and 김경환 and Jung, HeeYeon and 이상형},
title={Studies on signal transduction mechanism of alcohol-induced neuronal cell death and protective effect},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2004},
volume={17},
number={1},
pages={31-43},
doi={10.11637/aba.2004.17.1.31}

TY - JOUR
AU - 이도연
AU - Sung Su Kim
AU - 김경용
AU - Lee Won Bok
AU - 김대경
AU - 김경환
AU - Jung, HeeYeon
AU - 이상형
TI - Studies on signal transduction mechanism of alcohol-induced neuronal cell death and protective effect
JO - Anatomy & Biological Anthropology
PY - 2004
VL - 17
IS - 1
PB - 대한체질인류학회
SP - 31
EP - 43
SN - 2671-5651
AB - Excessive use of alcohol is a serious problem in our society and induces various, severe alcohol related diseases. The cytotoxicities of ethanol are still largely unknown. We studied the molecular mechanisms of EtOH-induced SK-NSH neuronal cell death and protective effects of baicalein and gramineus against EtOH-induced cytotoxicities.In our results, the cell death by EtOH showed morphologic features of apoptosis like as membrane blebbing, nuclear condensation and fragmentation. Furthermore, pretreated baicalein attenuated EtOH-induced neuronal cell death effectively. EtOH increased expression levels of p53 and both p53 antisense oligonucleotide and Pifithrin protected the cell death against EtOH. Also, EtOH induced mitochondrial event, collapse of mitochondrial membrane potential (∆Ψm) and caspase cascade as a downstream of mitochondria. Interestingly, baicalein decreased expression levels of p53 and inhibited collapse of mitochondrial membrane potential. These results suggest that baicalein reduces mitochondrial dysfunction induced by EtOH through down-regulation of p53 expression levels. Also, baicalein attenuated activation of caspase, which was triggered by mitochondrial malfunction. But gramineus didn’t have any protective effect. These results imply that baicalein significantly protects EtOH-induced neuronal cell death through regulating p53, mitochondrial dysfunction and caspase activation.
KW - Ethanol;Neuronal cell death;Baicalein;Gramineus;p53;Mitochondrial membrane potential (MMP);
DO - 10.11637/aba.2004.17.1.31
ER -

이도연, Sung Su Kim, 김경용, Lee Won Bok, 김대경, 김경환, Jung, HeeYeon and 이상형. (2004). Studies on signal transduction mechanism of alcohol-induced neuronal cell death and protective effect. Anatomy & Biological Anthropology, 17(1), 31-43.

이도연, Sung Su Kim, 김경용, Lee Won Bok, 김대경, 김경환, Jung, HeeYeon and 이상형. 2004, "Studies on signal transduction mechanism of alcohol-induced neuronal cell death and protective effect", Anatomy & Biological Anthropology, vol.17, no.1 pp.31-43. Available from: doi:10.11637/aba.2004.17.1.31

이도연, Sung Su Kim, 김경용, Lee Won Bok, 김대경, 김경환, Jung, HeeYeon, 이상형 "Studies on signal transduction mechanism of alcohol-induced neuronal cell death and protective effect" Anatomy & Biological Anthropology 17.1 pp.31-43 (2004) : 31.

이도연, Sung Su Kim, 김경용, Lee Won Bok, 김대경, 김경환, Jung, HeeYeon, 이상형. Studies on signal transduction mechanism of alcohol-induced neuronal cell death and protective effect. 2004; 17(1), 31-43. Available from: doi:10.11637/aba.2004.17.1.31

이도연, Sung Su Kim, 김경용, Lee Won Bok, 김대경, 김경환, Jung, HeeYeon and 이상형. "Studies on signal transduction mechanism of alcohol-induced neuronal cell death and protective effect" Anatomy & Biological Anthropology 17, no.1 (2004) : 31-43.doi: 10.11637/aba.2004.17.1.31

이도연; Sung Su Kim; 김경용; Lee Won Bok; 김대경; 김경환; Jung, HeeYeon; 이상형. Studies on signal transduction mechanism of alcohol-induced neuronal cell death and protective effect. Anatomy & Biological Anthropology, 17(1), 31-43. doi: 10.11637/aba.2004.17.1.31

이도연; Sung Su Kim; 김경용; Lee Won Bok; 김대경; 김경환; Jung, HeeYeon; 이상형. Studies on signal transduction mechanism of alcohol-induced neuronal cell death and protective effect. Anatomy & Biological Anthropology. 2004; 17(1) 31-43. doi: 10.11637/aba.2004.17.1.31

이도연, Sung Su Kim, 김경용, Lee Won Bok, 김대경, 김경환, Jung, HeeYeon, 이상형. Studies on signal transduction mechanism of alcohol-induced neuronal cell death and protective effect. 2004; 17(1), 31-43. Available from: doi:10.11637/aba.2004.17.1.31

이도연, Sung Su Kim, 김경용, Lee Won Bok, 김대경, 김경환, Jung, HeeYeon and 이상형. "Studies on signal transduction mechanism of alcohol-induced neuronal cell death and protective effect" Anatomy & Biological Anthropology 17, no.1 (2004) : 31-43.doi: 10.11637/aba.2004.17.1.31