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@article{ART001143894},
author={김은경 and 이광소 and Chai Ok Hee and Song Chang Ho},
title={Inhibitory effect of Arctium lappa linne on compound 48/80-induced mast cell activation and vascular permeability},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2004},
volume={17},
number={1},
pages={55-66},
doi={10.11637/aba.2004.17.1.55}

TY - JOUR
AU - 김은경
AU - 이광소
AU - Chai Ok Hee
AU - Song Chang Ho
TI - Inhibitory effect of Arctium lappa linne on compound 48/80-induced mast cell activation and vascular permeability
JO - Anatomy & Biological Anthropology
PY - 2004
VL - 17
IS - 1
PB - 대한체질인류학회
SP - 55
EP - 66
SN - 2671-5651
AB - Arctium lappa Linne (AL) has been widely cultivated for a long time as a popular vegetable. The fruit of AL has been used as an antiphlogistic and expectorant in herbal medicine, the crude drug is known as “burdock” in korea. In pharmaceutical field, a few papers recently reported the antiinflammatory, antiviral, and anticancer effects of this extract. However, the antiallergic effect of AL is unknown. The purpose of this study is to investigate the inhibitory effect of AL on compound 48/80-induced mast cell activation. For this, the effects of AL on the degranulation, the histamine release, and the change of the intracellular cAMP (cyclic adenosine-3′, 5′ monophosphate) levels of rat peritoneal mast cells (RPMC) and the influences of AL on the compound 48/80-induced cutaneous reaction were studied. The results were as follows; 1) the compound 48/80-induced mast cell degranulation and histamine release of RPMC was significantly inhibited by pretreatment with AL, 2) the compound 48/80 decreased the cAMP levels of RPMC, but the compound 48/80-induced the cAMP levels of RPMC were significantly increased by pretreatment with AL, 4) AL significantly inhibited compound 48/80-induced vascular permeability of cutaneous tissue. From the above results, it is suggested that AL contains some substances which inhibit the compound 48/80-induced vascular permeability and mast cell activation.
KW - Mast cell;Arctium lappa Linne;Compound 48/80;Histamine release;cAMP;Vascular permeability
DO - 10.11637/aba.2004.17.1.55
ER -

김은경, 이광소, Chai Ok Hee and Song Chang Ho. (2004). Inhibitory effect of Arctium lappa linne on compound 48/80-induced mast cell activation and vascular permeability. Anatomy & Biological Anthropology, 17(1), 55-66.

김은경, 이광소, Chai Ok Hee and Song Chang Ho. 2004, "Inhibitory effect of Arctium lappa linne on compound 48/80-induced mast cell activation and vascular permeability", Anatomy & Biological Anthropology, vol.17, no.1 pp.55-66. Available from: doi:10.11637/aba.2004.17.1.55

김은경, 이광소, Chai Ok Hee, Song Chang Ho "Inhibitory effect of Arctium lappa linne on compound 48/80-induced mast cell activation and vascular permeability" Anatomy & Biological Anthropology 17.1 pp.55-66 (2004) : 55.

김은경, 이광소, Chai Ok Hee, Song Chang Ho. Inhibitory effect of Arctium lappa linne on compound 48/80-induced mast cell activation and vascular permeability. 2004; 17(1), 55-66. Available from: doi:10.11637/aba.2004.17.1.55

김은경, 이광소, Chai Ok Hee and Song Chang Ho. "Inhibitory effect of Arctium lappa linne on compound 48/80-induced mast cell activation and vascular permeability" Anatomy & Biological Anthropology 17, no.1 (2004) : 55-66.doi: 10.11637/aba.2004.17.1.55

김은경; 이광소; Chai Ok Hee; Song Chang Ho. Inhibitory effect of Arctium lappa linne on compound 48/80-induced mast cell activation and vascular permeability. Anatomy & Biological Anthropology, 17(1), 55-66. doi: 10.11637/aba.2004.17.1.55

김은경; 이광소; Chai Ok Hee; Song Chang Ho. Inhibitory effect of Arctium lappa linne on compound 48/80-induced mast cell activation and vascular permeability. Anatomy & Biological Anthropology. 2004; 17(1) 55-66. doi: 10.11637/aba.2004.17.1.55

김은경, 이광소, Chai Ok Hee, Song Chang Ho. Inhibitory effect of Arctium lappa linne on compound 48/80-induced mast cell activation and vascular permeability. 2004; 17(1), 55-66. Available from: doi:10.11637/aba.2004.17.1.55

김은경, 이광소, Chai Ok Hee and Song Chang Ho. "Inhibitory effect of Arctium lappa linne on compound 48/80-induced mast cell activation and vascular permeability" Anatomy & Biological Anthropology 17, no.1 (2004) : 55-66.doi: 10.11637/aba.2004.17.1.55