Immunohistochemical Study on the Distribution of Glycogen Synthase Kinase (GSK) 3β in theCentral Nervous System of SOD1G93A Transgenic Mice (SOD1G93A transgenic mice의 중추신경계에서glycogen synthase kinase (GSK) 3β의 분포에 관한면역조직화학적 연구)

주경민; 정윤희; 김성수; 김경용; 이원복; 차중익

doi:10.11637/aba.2007.20.4.355

Immunohistochemical Study on the Distribution of Glycogen Synthase Kinase (GSK) 3β in theCentral Nervous System of SOD1G93A Transgenic Mice

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2007, 20(4), pp.355~362
DOI : 10.11637/aba.2007.20.4.355
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

주경민 ¹, 정윤희 ², 김성수 ², 김경용 ², 이원복 ², 차중익 ¹

¹서울대학교
²중앙대학교

Accredited

ABSTRACT

In the present study, we investigated influences of glycogen synthase kinase (GSK) 3β on the development and/or progression of amyotrophic lateral sclerosis (ALS). We used transgenic mice expressing a human Cu/Zn superoxide dismutase mutant (SOD1G93A) as an in vivo model of ALS and examined expressional changes of GSK3β immunohistochemically in the spinal cord, brain stem and cerebellum. With these experiments we demonstrate that the neurons in these regions of symptomatic SOD1G93A transgenic mice showed increased GSK3β immunoreactivities compared with wild-type SOD1 transgenic mice. In contrast to symptomatic SOD1G93A transgenic mice, few GSK3β immunoreactivity changes were detected in 8w- and 13w-old presymptomatic SOD1G93A transgenic mice. These data suggest the possibility that GSK3 functions as a modulating factor of apoptosis-related alterations in ALS and that GSK3β exert differential functions in the development and/or progression of ALS. But the exact functional significances of these changes require further elucidation.

KEYWORDS

Glycogen synthase kinase (GSK) 3β, Amyotrophic lateral sclerosis (ALS), SOD1G93A transgenic mice, Spinal cord, Brain stem, Cerebellum

Citation status

* References for papers published after 2023 are currently being built.

[journal] Al-Chalabi A / 2000 / Recent advances in amyotrophic lateral sclerosis 13 : 397~405

[journal] Chung YH / 2003 / Reactive astrocytes express cAMP-response-element-binding protein (CREB) binding protein (CBP) in the central nervous system of transgenic mice expressing a human Cu/Zn superoxide dismutase mutation 343 : 159~162

[journal] Cleveland DW / 2001 / From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS 2 : 806~819

[journal] Frame S / 2001 / GSK3 takes centre stage more than 20 years after its discovery 359 : 1~16

[journal] Grimes CA / 2001 / The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling 65 : 391~426

[journal] Gurney ME / 1994 / Motor neurondegeneration in mice that express a human Cu : 1772~264 1775

[journal] Hanger DP / 1992 / Glycogen synthase kinase-3 induces Alzheimer’s diseaselikephosphorylation of tau generation of paired helicalfilament epitopes and neuronal localisation of the kinase : 58~62

[journal] Hoshi M / 1995 / Different localization of tau protein kinase I/glycogen synthase kinase-3 beta from glycogen synthase kinase-3 alpha in cerebellum mitochondria 118 : 683~685

[journal] Jope RS / 2004 / The glamour and gloom of glycogen synthase kinase-3 29 : 95~102

[journal] Julien JP / 2001 / Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded 104 : 581~591

[journal] Mandelkow EM / 1992 / Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associatedprotein tau 314 : 315~321

[journal] Ripps ME / 1995 / Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis 92 : 689~693

[journal] Sasaki S / 1999 / Immunoreactivity of beta-amyloid precursor protein in amyotrophic lateral sclerosis 97 : 463~468

[journal] Shin CM / 2000 / Immunohistochemical study on the distribution of Bcl-2 and Bax in the central nervous system of the transgenic mice expressing a human Cu/Zn SOD mutation 887 : 309~315

[journal] Takashima A / 1993 / Tau protein kinase I is essential for amyloid [beta]-proteininducedneurotoxicity 90 : 7789~7793

[journal] Takahashi M / 1994 / Localization and developmental changesof tau protein kinase I/glycogen synthase kinase-3 beta inrat brain 63 : 245~255

[journal] Tanji C / 2002 / A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta) and mediates protein kinase A-dependent inhibition of GSK-3beta 227 : 36955~36961

[journal] Yang W / 2003 / Microtubule-associated tau protein positive neuronal and glial inclusions in ALS 61 : 1766~1773

KJCKorea
Journal Central

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Immunohistochemical Study on the Distribution of Glycogen Synthase Kinase (GSK) 3β in theCentral Nervous System of SOD1G93A Transgenic Mice

ABSTRACT

KEYWORDS

Citation status

* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Immunohistochemical Study on the Distribution of Glycogen Synthase Kinase (GSK) 3β in theCentral Nervous System of SOD1G93A Transgenic Mice

ABSTRACT

KEYWORDS

Statistics

Tools

Issue List

Citation status

KCI Citation Counts (0)

REFERENCES (18) * References for papers published after 2023 are currently being built.

Search PDF

Citation

* References for papers published after 2023 are currently being built.