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@article{ART001264905},
author={오상수 and 임정민 and Hyoungtae Kim},
title={The Effects of Sciatic Neurectomy on Rat Gastrocnemius Muscle},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2008},
volume={21},
number={2},
pages={149-165},
doi={10.11637/aba.2008.21.2.149}

TY - JOUR
AU - 오상수
AU - 임정민
AU - Hyoungtae Kim
TI - The Effects of Sciatic Neurectomy on Rat Gastrocnemius Muscle
JO - Anatomy & Biological Anthropology
PY - 2008
VL - 21
IS - 2
PB - 대한체질인류학회
SP - 149
EP - 165
SN - 2671-5651
AB - The effects of unilateral sciatic neurectomy on gastrocnemius muscle were studied in adult male rats. The morphological changes of both gastrocnemius muscles were observed by light and electron microscopy. Western blot analysis was performed to study the protein expression. Following the denervation, the affected muscle weights decreased significantly than normal. And the denervation led to a significant reduction in the area and diameter of muscle fibers on light microscopy. The affected muscle fibers showed the decreasing in size and the irregularity of myofibrilar arrangement on electron microscopy. On transverse view, the area of affected muscle fibers were smaller than normal. Their myofibrils were smaller and very irregular in size. The thin and thick myofilaments were not regular and partially lost. Mitochondria between myofibrils and subsarcolemmal were mostly lost and irregular. Some satellite cells were observed adjacent the muscle fiber, but they were inactive morphologically. On longitudinal view, most of myofibrils in affected muscle fibers were lost generally or partially although the their most sarcomeres were regularly arranged. Z line and myofilaments were lost partially and were partially irregularly arranged. The loss of thin myofilaments was more than that of thick myofilaments. Much debris of cell organelles were scattered among myofibrils. The expression of MyoD and myogenin were decrease significantly and the expression of p-mTOR and p-FOXO1 were decreased, too. On the other hand, MuRF1 was increased significantly. Taken together, the main effect of gastrocnemius muscle by sciatic neurectomy is the atrophy as a result of the loss of myofilaments and cell organelles through the decrease of protein synthesis and the increase of protein degradation.
KW - Sciatic nerve;Neurectomy;Denervation;Atrophy;Muscle fiber;Gastrocnemius muscle
DO - 10.11637/aba.2008.21.2.149
ER -

오상수, 임정민 and Hyoungtae Kim. (2008). The Effects of Sciatic Neurectomy on Rat Gastrocnemius Muscle. Anatomy & Biological Anthropology, 21(2), 149-165.

오상수, 임정민 and Hyoungtae Kim. 2008, "The Effects of Sciatic Neurectomy on Rat Gastrocnemius Muscle", Anatomy & Biological Anthropology, vol.21, no.2 pp.149-165. Available from: doi:10.11637/aba.2008.21.2.149

오상수, 임정민, Hyoungtae Kim "The Effects of Sciatic Neurectomy on Rat Gastrocnemius Muscle" Anatomy & Biological Anthropology 21.2 pp.149-165 (2008) : 149.

오상수, 임정민, Hyoungtae Kim. The Effects of Sciatic Neurectomy on Rat Gastrocnemius Muscle. 2008; 21(2), 149-165. Available from: doi:10.11637/aba.2008.21.2.149

오상수, 임정민 and Hyoungtae Kim. "The Effects of Sciatic Neurectomy on Rat Gastrocnemius Muscle" Anatomy & Biological Anthropology 21, no.2 (2008) : 149-165.doi: 10.11637/aba.2008.21.2.149

오상수; 임정민; Hyoungtae Kim. The Effects of Sciatic Neurectomy on Rat Gastrocnemius Muscle. Anatomy & Biological Anthropology, 21(2), 149-165. doi: 10.11637/aba.2008.21.2.149

오상수; 임정민; Hyoungtae Kim. The Effects of Sciatic Neurectomy on Rat Gastrocnemius Muscle. Anatomy & Biological Anthropology. 2008; 21(2) 149-165. doi: 10.11637/aba.2008.21.2.149

오상수, 임정민, Hyoungtae Kim. The Effects of Sciatic Neurectomy on Rat Gastrocnemius Muscle. 2008; 21(2), 149-165. Available from: doi:10.11637/aba.2008.21.2.149

오상수, 임정민 and Hyoungtae Kim. "The Effects of Sciatic Neurectomy on Rat Gastrocnemius Muscle" Anatomy & Biological Anthropology 21, no.2 (2008) : 149-165.doi: 10.11637/aba.2008.21.2.149