Expression of VEGF and its Receptors, Flk-1 and Flt-1 in Postnatal Murine Cerebellum (출생 후 흰쥐 소뇌에서 VEGF와 그 수용체들의 발현)

김현; Ho Chan Kim (김호찬)

doi:10.11637/aba.2008.21.4.279

Expression of VEGF and its Receptors, Flk-1 and Flt-1 in Postnatal Murine Cerebellum

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2008, 21(4), pp.279~285
DOI : 10.11637/aba.2008.21.4.279
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

김현 ¹, Ho Chan Kim ¹

¹고신대학교

Accredited

ABSTRACT

VEGF and its receptors, flk-1 and flt-1 have been characterized as critical factors in angiogenesis and neurogenesis during development. Here we investigated the expression of VEGF and its receptors in postnatal murine cerebellum in terms of time-dependency and regional distribution. Immunofluorescence staining showed that the expression of VEGF was restricted only to Purkinje cells and was increased in their processes on the postnatal development. Flk-1 was expressed in Purkinje cellular bodies on postnatal day (P) 8, 11, 18. Flt-1 was expressed in Purkinje cells on P8 but gradually disappeared in all of cerebellar layers on the postnatal development. These results suggest that VEGF may contribute to postnatal development of cerebellum via its receptors. And they suggest that changes in the expression of VEGF and its receptors related to the difference in maturation and proliferation of Purkinje cells in the cerebellum.

KEYWORDS

Postnatal cerebellum, VEGF, Flk-1, Flt-1

Citation status

* References for papers published after 2023 are currently being built.

[journal] Al-Suhaili AR / 1997 / Agyria-pachygyria: cerebral perfusion studies by 99mTc-HMPAO SPECT [corrected]. / Brain Dev 19 : 138~143

[journal] Arbiser JL / 2000 / Overexpression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivo / Am J Pathol 156 : 1469~1476

[journal] Breier G / 1992 / Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation / Development 114 : 521~532

[journal] Ferrara N / 2000 / VEGF: an update on biological and therapeutic aspects / Curr Opin Biotechnol 11 : 617~624

[journal] Ferrara N / 1997 / The biology of vascular endothelial growth factor / Endocr Rev 18 : 4~25

[journal] Ferrara N / 1991 / The vascular endothelial growth factor family of polypeptides / J Cell Biochem 47 : 211~218

[journal] Fong GH / 1995 / Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium / Nature 376 : 66~70

[journal] Gerber HP / 1999 / VEGF is required for growth and survival in neonatal mice / Development 126 : 1149~1159

[journal] Gluzman-Poltorak Z / 2000 / Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected] / J Biol Chem 275 : 18040~18045

[journal] Hoehn BD / 2002 / VEGF mRNA expressed in microvessels of neonatal and adult rat cerebral cortex. / Brain Res Mol Brain Res 101 : 103~108

[confproc] Jin KL / 2000 / Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia / Proc Natl Acad Sci USA : 10242~10247

[journal] Kim H / 2004 / Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells / J Biol Chem 279 : 33538~33546

[journal] Kim HY / 2007 / Expression of vascular endothelial growth factor receptors Flt-1 and Flk- 1 in embryonic rat forebrain / Neurosci Lett 425 : 131~135

[journal] Kuo NT / 1999 / Prolonged hypoxia increases vascular endothelial growth factor mRNA and protein in adult mouse brain / J Appl Physiol 86 : 260~264

[journal] Ogunshola OO / 2002 / Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system / J Biol Chem 277 : 11410~11415

[journal] Ogunshola OO / 2000 / Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain / Brain Res Dev Brain Res 119 : 139~153

[journal] Sondell M / 2000 / Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor / Eur J Neurosci 12 : 4243~4254

[journal] Sotelo C / 2004 / Cellular and genetic regulation of the development of the cerebellar system / Prog Neurobiol 72 : 295~339

[journal] Surchev L / 2007 / Developmental increase of total cell numbers in the murine cerebellum. / Cerebellum : 1~6

[journal] Weisheit G / 2006 / Postnatal development of the murine cerebellar cortex: formation and early dispersal of basket, stellate and Golgi neurons / Eur J Neurosci 24 : 466~478

[journal] Yang SZ / 2003 / Distribution of Flk-1 and Flt-1 receptors in neonatal and adult rat brains / Anat Rec A Discov Mol Cell Evol Biol 274 : 851~856

KJCKorea
Journal Central

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Expression of VEGF and its Receptors, Flk-1 and Flt-1 in Postnatal Murine Cerebellum

ABSTRACT

KEYWORDS

Citation status

* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Expression of VEGF and its Receptors, Flk-1 and Flt-1 in Postnatal Murine Cerebellum

ABSTRACT

KEYWORDS

Statistics

Tools

Issue List

Citation status

KCI Citation Counts (0)

REFERENCES (21) * References for papers published after 2023 are currently being built.

Search PDF

Citation

* References for papers published after 2023 are currently being built.