@article{ART001302212},
author={KIM, DAE-KWANG},
title={Evaluation of Single Nucleotide Polymorphism Responsible for the Determination of Earwax Type in Koreans},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2008},
volume={21},
number={4},
pages={287-291},
doi={10.11637/aba.2008.21.4.287}
TY - JOUR
AU - KIM, DAE-KWANG
TI - Evaluation of Single Nucleotide Polymorphism Responsible for the Determination of Earwax Type in Koreans
JO - Anatomy & Biological Anthropology
PY - 2008
VL - 21
IS - 4
PB - 대한체질인류학회
SP - 287
EP - 291
SN - 2671-5651
AB - The ABCC11 gene is a member of the ATP-binding cassette gene family. A single nucleotide polymorphism
(SNP) in the ABCC11 gene is associated with the determination of human earwax type. The purpose of this research is
to evaluate the allelic frequencies of this gene in Korean population samples. A total of 619 individuals were analyzed
by Dde I restriction fragment length polymorphisms (RFLPs). The genotype frequency of dry earwax in Koreans was
very high. The proportions of dry/dry genotype found were 99% (99/100) in normal controls; 98.1% (207/211) in patients
with schizophrenia; 99% (99/100) in patients with breast cancer; 96% (48/50) patients with uterine myoma; 98.3%
(59/60) in obesity subjects; 100% (43/43) in patients with stomach cancer, and 98.2% (54/55) in attention deficit hyperactivity
disorder (ADHD) patients. The wet/wet genotype was not found. There were no significant differences in the
distribution of earwax genotypes between controls and experimental groups. These results suggest that the frequency of
dry earwax are very high, and therefore the SNP determining earwax type will not be useful in genetic studies of the
process involved in various diseases or pathologic conditions in Korean populations.
KW - Earwax type;Polymorphism;ABCC11 gene
DO - 10.11637/aba.2008.21.4.287
ER -
KIM, DAE-KWANG. (2008). Evaluation of Single Nucleotide Polymorphism Responsible for the Determination of Earwax Type in Koreans. Anatomy & Biological Anthropology, 21(4), 287-291.
KIM, DAE-KWANG. 2008, "Evaluation of Single Nucleotide Polymorphism Responsible for the Determination of Earwax Type in Koreans", Anatomy & Biological Anthropology, vol.21, no.4 pp.287-291. Available from: doi:10.11637/aba.2008.21.4.287
KIM, DAE-KWANG "Evaluation of Single Nucleotide Polymorphism Responsible for the Determination of Earwax Type in Koreans" Anatomy & Biological Anthropology 21.4 pp.287-291 (2008) : 287.
KIM, DAE-KWANG. Evaluation of Single Nucleotide Polymorphism Responsible for the Determination of Earwax Type in Koreans. 2008; 21(4), 287-291. Available from: doi:10.11637/aba.2008.21.4.287
KIM, DAE-KWANG. "Evaluation of Single Nucleotide Polymorphism Responsible for the Determination of Earwax Type in Koreans" Anatomy & Biological Anthropology 21, no.4 (2008) : 287-291.doi: 10.11637/aba.2008.21.4.287
KIM, DAE-KWANG. Evaluation of Single Nucleotide Polymorphism Responsible for the Determination of Earwax Type in Koreans. Anatomy & Biological Anthropology, 21(4), 287-291. doi: 10.11637/aba.2008.21.4.287
KIM, DAE-KWANG. Evaluation of Single Nucleotide Polymorphism Responsible for the Determination of Earwax Type in Koreans. Anatomy & Biological Anthropology. 2008; 21(4) 287-291. doi: 10.11637/aba.2008.21.4.287
KIM, DAE-KWANG. Evaluation of Single Nucleotide Polymorphism Responsible for the Determination of Earwax Type in Koreans. 2008; 21(4), 287-291. Available from: doi:10.11637/aba.2008.21.4.287
KIM, DAE-KWANG. "Evaluation of Single Nucleotide Polymorphism Responsible for the Determination of Earwax Type in Koreans" Anatomy & Biological Anthropology 21, no.4 (2008) : 287-291.doi: 10.11637/aba.2008.21.4.287
