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@article{ART001380205},
author={김승오 and BYUNG RYUL CHO and 김대중 and 김민경 and Seung Soo Lee},
title={Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2009},
volume={22},
number={3},
pages={245-254},
doi={10.11637/aba.2009.22.3.245}

TY - JOUR
AU - 김승오
AU - BYUNG RYUL CHO
AU - 김대중
AU - 김민경
AU - Seung Soo Lee
TI - Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway
JO - Anatomy & Biological Anthropology
PY - 2009
VL - 22
IS - 3
PB - 대한체질인류학회
SP - 245
EP - 254
SN - 2671-5651
AB - Multifunctional tissue transglutaminase (tTGase) is found in the cytoplasm and cell surface, as well as in the extracellular matrix. However, it is difficult to determine the exact function of tTGase in each cell compartment. This study focused on the potential role of cell surface tTGase in the process of “outside-in” signal transduction. Immunofluorescence study and western blotting was performed to localize the overexpression of tTGase. tTGaseoverexpressed H9c2/tTGase cells were treated with anti-tTGase antibody to evaluate the potential functions of tTGase on the outside-in signal process. The tTGase level markedly increased in each cell compartment and the culture media of H9c2/tTGase cells that show overexpression of tTGases. Anti-tTGase monoclonal antibody reduced tTGase levels in the whole lysate of H9c2/tTGase cells, and concomitantly increased the activity of the Akt. The results suggest that the cell surface expression of tTGase may be associated with an intracellular signaling pathway via the phosphoinositol-3 kinase/Akt. Phosphorylation of mitogen activated protein kinase family, ERK1/2, and Jun N-terminal Kinase (JNK), was also inhibited in the anti-tTGase antibody-treated H9c2/tTGase cells. These results suggest that cell surface tTGase may regulate intracellular signaling pathways in an autocrine or paracrine manner.
KW - tissue transglutaminase;PI-3K;신호전달
DO - 10.11637/aba.2009.22.3.245
ER -

김승오, BYUNG RYUL CHO, 김대중, 김민경 and Seung Soo Lee. (2009). Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway. Anatomy & Biological Anthropology, 22(3), 245-254.

김승오, BYUNG RYUL CHO, 김대중, 김민경 and Seung Soo Lee. 2009, "Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway", Anatomy & Biological Anthropology, vol.22, no.3 pp.245-254. Available from: doi:10.11637/aba.2009.22.3.245

김승오, BYUNG RYUL CHO, 김대중, 김민경, Seung Soo Lee "Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway" Anatomy & Biological Anthropology 22.3 pp.245-254 (2009) : 245.

김승오, BYUNG RYUL CHO, 김대중, 김민경, Seung Soo Lee. Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway. 2009; 22(3), 245-254. Available from: doi:10.11637/aba.2009.22.3.245

김승오, BYUNG RYUL CHO, 김대중, 김민경 and Seung Soo Lee. "Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway" Anatomy & Biological Anthropology 22, no.3 (2009) : 245-254.doi: 10.11637/aba.2009.22.3.245

김승오; BYUNG RYUL CHO; 김대중; 김민경; Seung Soo Lee. Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway. Anatomy & Biological Anthropology, 22(3), 245-254. doi: 10.11637/aba.2009.22.3.245

김승오; BYUNG RYUL CHO; 김대중; 김민경; Seung Soo Lee. Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway. Anatomy & Biological Anthropology. 2009; 22(3) 245-254. doi: 10.11637/aba.2009.22.3.245

김승오, BYUNG RYUL CHO, 김대중, 김민경, Seung Soo Lee. Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway. 2009; 22(3), 245-254. Available from: doi:10.11637/aba.2009.22.3.245

김승오, BYUNG RYUL CHO, 김대중, 김민경 and Seung Soo Lee. "Cell Surface Tissue Transglutaminase-induced Activation of Phosphoinositol 3-Kinase/Akt Pathway" Anatomy & Biological Anthropology 22, no.3 (2009) : 245-254.doi: 10.11637/aba.2009.22.3.245