Feasibility of CD147 for an Eruption-Related Molecule during Rat Molar Development

강지혜; Kim Hyun Jin (김현진); 정지연; 김민석; Kim Won Jae (김원재); 이은주; 김선헌; 정준용; 고현미

doi:10.11637/aba.2009.22.3.235

Feasibility of CD147 for an Eruption-Related Molecule during Rat Molar Development

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2009, 22(3), pp.235~244
DOI : 10.11637/aba.2009.22.3.235
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

강지혜 ¹, Kim Hyun Jin ², 정지연 ¹, 김민석 ¹, Kim Won Jae ¹, 이은주 ¹, 김선헌 ¹, 정준용 ¹, 고현미 ¹

¹전남대학교
²원광대학교

Accredited

ABSTRACT

Understanding the genetic control of tooth eruption is one of the major issues in tooth development. Thus far, it is known that eruption-related molecules are secreted from follicular cells surrounding the germs and are related mainly to osteoclast formation. This study examined the involvement of CD147 and its downstream molecules in the eruption of rat developing molars using immunohistochemistry, RT-PCR and histomorphometry. CD147 was expressed differentially in the cap (3rd molar germs) and root formation (2nd molar germs) stages in tooth development. CD147 was localized immunohistochemically in the follicular cells and osteoclasts as well as in the ameloblasts and odontoblasts. The expression pattern of CD147 and mmps was investigated because CD147 is an mmp inducer. The expression of both mmp-2 and -9 increased at the root formation stage compared to that at the cap stage and increased in a stage dependent manner. However, the level of mmp-13 was not changed notably. The histomorphometrical study suggested that the number of osteoclasts that appeared occlusal to the molar germs for the resorption of alveolar bone increased significantly during development. These results suggest that CD147 may play an important role in the formation of the eruption pathway along with the mmps.

KEYWORDS

CD147, Tooth eruption, mmps

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[journal] Bartlett JD / 2003 / Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice / Connect Tissue Res 44 : 300~304

[journal] Beertsen W / 2002 / On the role of MT1-MMP, a matrix metalloproteinase essential to collagen remodeling, in murine molar eruption and root growth / Eur J Oral Sci 110 : 445~451

[journal] Beertsen W / 2003 / Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice / Connect Tissue Res 44 : 298~299

[journal] Blavier L / 1995 / Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones / J Cell Sci 108 : 3649~3759

[journal] Creemers LB / 1998 / Gelatinase A (MMP-2) and cysteine proteinases are essential for the degradation of collagen in soft connective tissue / Matrix Biol 17 : 35~46

[journal] De Ceuninck F / 2003 / High binding capacity of cyclophilin B to chondrocyte heparan sulfate proteoglycans and its release from the cell surface by matrix metalloproteinases: possible role as a proinflammatory mediator in arthritis / Arthritis Rheum 48 : 2197~2206

[journal] Everts V / 1996 / Phagocytosis and intracellular digestion of collagen, its role in turnover and remodelling / Histochem J 28 : 229~245

[journal] Gabison EE / 2005 / EMMPRIN/ CD147, an MMP modulator in cancer, development and tissue repair / Biochimie 87 : 361~368

[journal] Gerber HP / 1999 / VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation / Nat Med 5 : 623~628

[journal] Holmbeck K / 2005 / The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone / J Cell Sci 1 : 147~156

[journal] Huet E / 2008 / Role of emmprin/ CD147 in tissue remodeling / Connective Tissue Res 49 : 175~179

[journal] Kasinrerk W / 1999 / CD147 monoclonal antibodies induce homotypic cell aggregation of monocytic cell line U937 via LFA-1/ICAM-1 pathwa / Immunology 96 : 184~192

[journal] Kerkvliet EH / 1999 / Collagen breakdown in soft connective tissue explants is associated with the level of active gelatinase A (MMP-2) but not with collagenase / Matrix Biol 18 : 373~380

[journal] Li R / 2001 / Basigin (murine EMMPRIN) stimulates matrix metalloproteiase production by fibroblasts / J Cell Physiol 186 : 371~379

[journal] Liang L / 2002 / Characterization of the promoter of human extracellular matrix metalloproteinase inducer (EMMPRIN) / Gene 282 : 75~86

[journal] Major TC / 2002 / Extracellular matrix metalloproteinase inducer (EMMPRIN) is induced upon monocyte differentiation and is expressed in human atheroma / Arterioscler Thromb Vasc Biol 22 : 1200~1207

[journal] Martel-Pelletier J / 1996 / Wanted-the collagenase responsible for the destruction of the collagen network in human cartilage / Br J Rheumatol 35 : 818~820

[journal] Martignetti JA / 2001 / Mutation of the matrix metalloproteinase 2 gene (MMP-2) causes a multicentric osteolysis and arthritis syndrome / Nat Genet 28 : 261~265

[journal] Niida S / 1997 / Restoration of disturbed tooth eruption in osteopetrotic (op/op) mice by injection of macrophage colony-stimulating factor / Exp Anim 46 : 95~101

[journal] Norgauer J / 2002 / Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers / Br J Dermatol 147 : 1180~1186

[journal] Okaji M / 2003 / The regulation of bone resorption in tooth formation and eruption processes in mouse alveolar crest devoid of cathepsin K / J Pharmacol Sci 91 : 285~294

[journal] Palosaari H / 2003 / Expression profile of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue / Eur J Oral Sci 111 : 117~127

[journal] Sahlberg C / 1999 / Timp-1, -2 and -3 show coexpression with gelatinases A and B during mouse tooth morphogenesis / Eur J Oral Sci 107 : 121~130

[journal] Sameshima T / 2000 / Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix metalloproteinase and activated gelatinase A in co-cultures with brainderived fibroblasts / Cancer Lett 157 : 177~184

[journal] Si AI / 2003 / Expression and localizationof extracellular matrix metalloproteinase inducer in giant cell tumor of bone / J Cell Biochem 89 : 1154~1163

[journal] Sun J / 2001 / Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions / Cancer Res 61 : 2276~2281

[journal] Tang Y / 2004 / Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN / Mol Cancer Res 2 : 73~80

[journal] Verma DK / 2005 / Quantitative histological features and ultrastructure of opercula of human teeth showing normal and delayed eruption / J Oral Pathol Med 34 : 109~115

[journal] Wise GE / 2000 / Enhancement of gene expression in rat dental follicle cells by parathyroid hormone-related protein / Arch Oral Biol 45 : 903~909

[journal] Yurchenko V / 2006 / Dealing with the family: CD147 interactions with cyclophilins / Immunology 117 : 301~309

[journal] Yurchenko V / 2001 / CD147 is a signaling receptor for cyclophilin B / Biochem Biophys Res Commun 288 : 786~788

[journal] Yurchenko V / 2002 / Active site residues of cyclophilin A are crucial for signalling activity via CD147 / J Biol Chem 277 : 22959~22965

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Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Feasibility of CD147 for an Eruption-Related Molecule during Rat Molar Development

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Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Feasibility of CD147 for an Eruption-Related Molecule during Rat Molar Development

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