Scutellaria baicalensis Inhibits Mast Cell-Mediated Anaphylactic Reactions

Choi Yun Ho (최윤호); 한의혁; 채옥희; 김윤규; 김형태; 송창호

doi:10.11637/aba.2010.23.4.217

Scutellaria baicalensis Inhibits Mast Cell-Mediated Anaphylactic Reactions

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2010, 23(4), pp.217~227
DOI : 10.11637/aba.2010.23.4.217
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

Choi Yun Ho ¹, 한의혁 ², 채옥희 ², 김윤규 ¹, 김형태 ², 송창호 ²

¹전북대학교 의학전문대학원 해부학교실, 전북대학교 의과학 연구소
²전북대학교

Accredited

ABSTRACT

Mast cells play a critical role in the effector phase of immediate hypersensitivity and allergic diseases. Scutellaria baicalensis is a widely used herb in traditional oriental medicine with anticancer, antiviral, antibacterial and anti-inflammatory properties. However, the roles of Scutellaria baicalensis in mast cell-mediated anaphylactic reactions have not fully been investigated. In this study, we examined the influences of the methanol extract of Scutellaria baicalensis (MESB) on compound 48/80- or anti-dinitrophenyl (DNP) IgE-induced anaphylaxis-like response in vivo. To further prove these in vivo results, the inhibitory effect of MESB on mast cell activation was evaluated, focusing on the histamine release from rat peritoneal mast cells (RPMC). MESB inhibited compound 48/80-induced systemic anaphylaxis-like reaction, plasma histamine release and ear swelling response in mice. MESB also attenuated passive systemic and cutaneous anaphylaxis evoked by anti-DNP IgE. In in vitro experiments, MESB dose-dependently reduced histamine release from RPMC activated by compound 48/80 or anti-DNP IgE. Moreover, compound 48/80-elicited calcium uptake was suppressed in a concentration-dependent manner of MESB. Furthermore, MESB transiently increased the level of intracellular cAMP. From these results, it is suggested that MESB possesses effective anti-anaphylactic activity.

KEYWORDS

Mast cells, Anaphylactic reactions, Scutellaria baicalensis, Histamine, Calcium, cAMP

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This paper was written with support from the National Research Foundation of Korea.

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Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Scutellaria baicalensis Inhibits Mast Cell-Mediated Anaphylactic Reactions

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* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Scutellaria baicalensis Inhibits Mast Cell-Mediated Anaphylactic Reactions

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