@article{ART001509469},
author={강기영 and 김현},
title={Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2010},
volume={23},
number={4},
pages={207-215},
doi={10.11637/aba.2010.23.4.207}
TY - JOUR
AU - 강기영
AU - 김현
TI - Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats
JO - Anatomy & Biological Anthropology
PY - 2010
VL - 23
IS - 4
PB - 대한체질인류학회
SP - 207
EP - 215
SN - 2671-5651
AB - Transforming growth factor-β1 (TGF-β1) has chemotactic effect to monocytes, macrophages and fibroblasts,and it stimulates those cells to produce growth factors and collagen fibers. Therefore, TGF-β1 plays important roles in the wound healing process. The aim of this study is to evaluate the effects of recombinant human TGF-β1(rhTGF-β1) on the wound healing defect in dexamethasone-treated rats.
Dexamethasone (0.1 mg/kg/day) was subcutaneously injected into the eight-week-old Sprague-Dawley rats. At the third day of dexamethasone administration, full thickness wounds were made on the back of the rat. And then,rhTGF-β1 (50 ng/wound) was intradermally injected in the vicinity of the wounds. The wounds of the normal and the negative control groups were provided with vehicle only. At 1, 3, 5, 7 and 15 days after the surgery, the wound sizes were measured and the wound tissues were obtained and analyzed.
The mean wound sizes of the rhTGF-β1 injected groups were significantly smaller than those of the negative control groups. Moreover, the histologic findings such as cellular infiltration, re-epithelialization and granulation formation and expression patterns of TGF-βs during the wound healing process were improved by administration of rhTGF-β1. These results support that rhTGF-β1 can restore wound healing defect due to dexamethasone administration.
KW - rhTGF-β1;TGF-β;Wound healing;Dexamethasone
DO - 10.11637/aba.2010.23.4.207
ER -
강기영 and 김현. (2010). Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats. Anatomy & Biological Anthropology, 23(4), 207-215.
강기영 and 김현. 2010, "Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats", Anatomy & Biological Anthropology, vol.23, no.4 pp.207-215. Available from: doi:10.11637/aba.2010.23.4.207
강기영, 김현 "Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats" Anatomy & Biological Anthropology 23.4 pp.207-215 (2010) : 207.
강기영, 김현. Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats. 2010; 23(4), 207-215. Available from: doi:10.11637/aba.2010.23.4.207
강기영 and 김현. "Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats" Anatomy & Biological Anthropology 23, no.4 (2010) : 207-215.doi: 10.11637/aba.2010.23.4.207
강기영; 김현. Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats. Anatomy & Biological Anthropology, 23(4), 207-215. doi: 10.11637/aba.2010.23.4.207
강기영; 김현. Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats. Anatomy & Biological Anthropology. 2010; 23(4) 207-215. doi: 10.11637/aba.2010.23.4.207
강기영, 김현. Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats. 2010; 23(4), 207-215. Available from: doi:10.11637/aba.2010.23.4.207
강기영 and 김현. "Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats" Anatomy & Biological Anthropology 23, no.4 (2010) : 207-215.doi: 10.11637/aba.2010.23.4.207
