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@article{ART001563096},
author={김민정 and 양성준 and 김강련 and 김현},
title={L-PDMP, Ganglioside Synthesis Enhancer Protects Dopaminergic Neurons from Death by Proteasomal Inhibition and the Accumulation of α-synuclein},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2011},
volume={24},
number={2},
pages={77-84},
doi={10.11637/aba.2011.24.2.77}

TY - JOUR
AU - 김민정
AU - 양성준
AU - 김강련
AU - 김현
TI - L-PDMP, Ganglioside Synthesis Enhancer Protects Dopaminergic Neurons from Death by Proteasomal Inhibition and the Accumulation of α-synuclein
JO - Anatomy & Biological Anthropology
PY - 2011
VL - 24
IS - 2
PB - 대한체질인류학회
SP - 77
EP - 84
SN - 2671-5651
AB - Gangliosides are components of the membranous constituents and abundant in the nervous system. And they are implicated in a wide range of biological activities including the regulation of cell proliferation, differentiation and lysosomal activity. But they have a diverse action to induce neuronal cell death by the interaction with some ligands. The interference of their biosynthesis is accompanied by the intracellular accumulation of unwanted and neurotoxic proteins and might underlie the neurodegeneration diseases including Parkinson’s disease. However the mechanism has not been elucidated. In this study, we report that the enhancement of biosynthesis of ganglioside GD3 protects the intracellular accumulation of α-synuclein and neuronal death. PC12 cells, dopaminergic neurons are cultured with synthetic proteasomal inhibitor (PSI, Z-lle-Glu(OtBu)-Ala-Leu-al) and L-PDMP (GD3 synthetase enhancer, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol). We found that the neuronal viability was recovered by L-PDMP from the proteasomal inhibition and also the expression of activated caspase-3 and PARP was reduced. L-PDMP decreased in the intracellular accumulation of α-synuclein. Interestingly, PSI induced the expression of ganglioside3 in PC12 cell. Our findings suggest that proteasomal inhibition may modulate the biosynthesis of GD3 and L-PDMP protects dopaminergic neurons from death by proteasomal inhibition and the accumulation of α-synuclein.
KW - Ganglioside3;L-PDMP;Proteasomal inhibitor;α-synuclein;Dopaminergic neuron
DO - 10.11637/aba.2011.24.2.77
ER -

김민정, 양성준, 김강련 and 김현. (2011). L-PDMP, Ganglioside Synthesis Enhancer Protects Dopaminergic Neurons from Death by Proteasomal Inhibition and the Accumulation of α-synuclein. Anatomy & Biological Anthropology, 24(2), 77-84.

김민정, 양성준, 김강련 and 김현. 2011, "L-PDMP, Ganglioside Synthesis Enhancer Protects Dopaminergic Neurons from Death by Proteasomal Inhibition and the Accumulation of α-synuclein", Anatomy & Biological Anthropology, vol.24, no.2 pp.77-84. Available from: doi:10.11637/aba.2011.24.2.77

김민정, 양성준, 김강련, 김현 "L-PDMP, Ganglioside Synthesis Enhancer Protects Dopaminergic Neurons from Death by Proteasomal Inhibition and the Accumulation of α-synuclein" Anatomy & Biological Anthropology 24.2 pp.77-84 (2011) : 77.

김민정, 양성준, 김강련, 김현. L-PDMP, Ganglioside Synthesis Enhancer Protects Dopaminergic Neurons from Death by Proteasomal Inhibition and the Accumulation of α-synuclein. 2011; 24(2), 77-84. Available from: doi:10.11637/aba.2011.24.2.77

김민정, 양성준, 김강련 and 김현. "L-PDMP, Ganglioside Synthesis Enhancer Protects Dopaminergic Neurons from Death by Proteasomal Inhibition and the Accumulation of α-synuclein" Anatomy & Biological Anthropology 24, no.2 (2011) : 77-84.doi: 10.11637/aba.2011.24.2.77

김민정; 양성준; 김강련; 김현. L-PDMP, Ganglioside Synthesis Enhancer Protects Dopaminergic Neurons from Death by Proteasomal Inhibition and the Accumulation of α-synuclein. Anatomy & Biological Anthropology, 24(2), 77-84. doi: 10.11637/aba.2011.24.2.77

김민정; 양성준; 김강련; 김현. L-PDMP, Ganglioside Synthesis Enhancer Protects Dopaminergic Neurons from Death by Proteasomal Inhibition and the Accumulation of α-synuclein. Anatomy & Biological Anthropology. 2011; 24(2) 77-84. doi: 10.11637/aba.2011.24.2.77

김민정, 양성준, 김강련, 김현. L-PDMP, Ganglioside Synthesis Enhancer Protects Dopaminergic Neurons from Death by Proteasomal Inhibition and the Accumulation of α-synuclein. 2011; 24(2), 77-84. Available from: doi:10.11637/aba.2011.24.2.77

김민정, 양성준, 김강련 and 김현. "L-PDMP, Ganglioside Synthesis Enhancer Protects Dopaminergic Neurons from Death by Proteasomal Inhibition and the Accumulation of α-synuclein" Anatomy & Biological Anthropology 24, no.2 (2011) : 77-84.doi: 10.11637/aba.2011.24.2.77