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@article{ART001588831},
author={Hak-Jong Choi and Hee-Woo Lee and Jong-Hun Park and Sae-Ock Oh and 백선용 and 김봉선 and 윤식},
title={Expression of IL-17A during Thymus Regeneration in the Rat},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2011},
volume={24},
number={3},
pages={141-154},
doi={10.11637/aba.2011.24.3.141}

TY - JOUR
AU - Hak-Jong Choi
AU - Hee-Woo Lee
AU - Jong-Hun Park
AU - Sae-Ock Oh
AU - 백선용
AU - 김봉선
AU - 윤식
TI - Expression of IL-17A during Thymus Regeneration in the Rat
JO - Anatomy & Biological Anthropology
PY - 2011
VL - 24
IS - 3
PB - 대한체질인류학회
SP - 141
EP - 154
SN - 2671-5651
AB - IL-17A is a pro-inflammatroy cytokine secreted by activated T cells. The IL-17 family consist of IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17A and IL-17F are produced primarily in activated T cells. In contrast, IL-17B, IL-17C, IL-17D and IL-17E are expressed in a wide assortment of tissues. Their functions partially overlap those of IL-17A, although they have not been as thoroughly investigated. The receptor for IL-17A (IL-17R) is widely expressed in a variety of tissues. IL-17A and IL-17E mRNAs were expressed in only EL4 cells. IL-17C mRNA expression was observed in the thymic subcapsular/cortex epithelial cells (SNEC), cortex or cortical reticular cells (CREC), medullary epithelial cells (MEC), medullary interdigitating-like cells (MDC), thymocytes and EL4 cells. However, IL-17C mRNA was not expressed in RAW 264.7 cells. Immunohistochemical study also demonstrated not only the presence of IL-17A mainly in the thymic epithelial cells, but also the upregulated expression of IL-17A in the thymic epithelial cells of the regenerating thymus. Thus, the results of the present study suggest that IL-17A expressed in the thymocytes and thymic epithelial cells could play an important role in the development of new T cells to replace T cells damaged by cyclophosphamide treatment during thymus regeneration.
KW - IL-17;IL-17A;Thymus;Thymic stromal cells;Thymocytes;Thymic epithelial cells;Thymus regeneration
DO - 10.11637/aba.2011.24.3.141
ER -

Hak-Jong Choi, Hee-Woo Lee, Jong-Hun Park, Sae-Ock Oh, 백선용, 김봉선 and 윤식. (2011). Expression of IL-17A during Thymus Regeneration in the Rat. Anatomy & Biological Anthropology, 24(3), 141-154.

Hak-Jong Choi, Hee-Woo Lee, Jong-Hun Park, Sae-Ock Oh, 백선용, 김봉선 and 윤식. 2011, "Expression of IL-17A during Thymus Regeneration in the Rat", Anatomy & Biological Anthropology, vol.24, no.3 pp.141-154. Available from: doi:10.11637/aba.2011.24.3.141

Hak-Jong Choi, Hee-Woo Lee, Jong-Hun Park, Sae-Ock Oh, 백선용, 김봉선, 윤식 "Expression of IL-17A during Thymus Regeneration in the Rat" Anatomy & Biological Anthropology 24.3 pp.141-154 (2011) : 141.

Hak-Jong Choi, Hee-Woo Lee, Jong-Hun Park, Sae-Ock Oh, 백선용, 김봉선, 윤식. Expression of IL-17A during Thymus Regeneration in the Rat. 2011; 24(3), 141-154. Available from: doi:10.11637/aba.2011.24.3.141

Hak-Jong Choi, Hee-Woo Lee, Jong-Hun Park, Sae-Ock Oh, 백선용, 김봉선 and 윤식. "Expression of IL-17A during Thymus Regeneration in the Rat" Anatomy & Biological Anthropology 24, no.3 (2011) : 141-154.doi: 10.11637/aba.2011.24.3.141

Hak-Jong Choi; Hee-Woo Lee; Jong-Hun Park; Sae-Ock Oh; 백선용; 김봉선; 윤식. Expression of IL-17A during Thymus Regeneration in the Rat. Anatomy & Biological Anthropology, 24(3), 141-154. doi: 10.11637/aba.2011.24.3.141

Hak-Jong Choi; Hee-Woo Lee; Jong-Hun Park; Sae-Ock Oh; 백선용; 김봉선; 윤식. Expression of IL-17A during Thymus Regeneration in the Rat. Anatomy & Biological Anthropology. 2011; 24(3) 141-154. doi: 10.11637/aba.2011.24.3.141

Hak-Jong Choi, Hee-Woo Lee, Jong-Hun Park, Sae-Ock Oh, 백선용, 김봉선, 윤식. Expression of IL-17A during Thymus Regeneration in the Rat. 2011; 24(3), 141-154. Available from: doi:10.11637/aba.2011.24.3.141

Hak-Jong Choi, Hee-Woo Lee, Jong-Hun Park, Sae-Ock Oh, 백선용, 김봉선 and 윤식. "Expression of IL-17A during Thymus Regeneration in the Rat" Anatomy & Biological Anthropology 24, no.3 (2011) : 141-154.doi: 10.11637/aba.2011.24.3.141