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@article{ART001588836},
author={Moon Yeon Hee and Jee-Hae Kang and 정남중 and 고현미 and 이은주 and 김선헌 and 김민석},
title={Expression of Tissue Inhibitors of Metalloproteinases in Developing Rat Tooth Germs},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2011},
volume={24},
number={3},
pages={175-183},
doi={10.11637/aba.2011.24.3.175}

TY - JOUR
AU - Moon Yeon Hee
AU - Jee-Hae Kang
AU - 정남중
AU - 고현미
AU - 이은주
AU - 김선헌
AU - 김민석
TI - Expression of Tissue Inhibitors of Metalloproteinases in Developing Rat Tooth Germs
JO - Anatomy & Biological Anthropology
PY - 2011
VL - 24
IS - 3
PB - 대한체질인류학회
SP - 175
EP - 183
SN - 2671-5651
AB - Tissue inhibitors of metalloproteinases (TIMPs) are a family of secreted molecules that were identified as natural inhibitors of matrix metalloproteinases (MMPs). Tooth histomorphogenesis and cytodifferentiation are accompanied by rapid changes in cellular organization and remodeling of the extracellular matrix, in which MMPs and TIMPs might be expected to play significant roles. This study examined the expression and localization of TIMP-1 and TIMP-2 during the molar development of rats. The expression patterns of TIMPs were determined from Sprague-Dawley rat pups including the developing molars using RT-PCR, western blot and immunofluorescent staining. Gene and protein quantification analyses showed that both TIMPs increased from the cap stage to the root stage tooth germs. In contrast, the immunofluorescent data showed that they were expressed slight differentially. TIMP-1was strongly expressed in secretory ameloblasts and moderate immunoreactivity was observed along the basement membrane. TIMP-2 expression was also detected in the basement membrane. Although strong immunoreactivity was observed in the secretory ameloblasts and enamel matrix itself, differentiated odontoblasts showed weak reactivity. However, little reactivity for both TIMPs were detected in the cap stage tooth germs and surrounding tissues. These distinct temporospatial expression patterns of TIMPs suggest that the TIMPs may play a variety of roles including dental hard tissue formation during molar tooth development.
KW - MMP;TIMP;Tooth development
DO - 10.11637/aba.2011.24.3.175
ER -

Moon Yeon Hee, Jee-Hae Kang, 정남중, 고현미, 이은주, 김선헌 and 김민석. (2011). Expression of Tissue Inhibitors of Metalloproteinases in Developing Rat Tooth Germs. Anatomy & Biological Anthropology, 24(3), 175-183.

Moon Yeon Hee, Jee-Hae Kang, 정남중, 고현미, 이은주, 김선헌 and 김민석. 2011, "Expression of Tissue Inhibitors of Metalloproteinases in Developing Rat Tooth Germs", Anatomy & Biological Anthropology, vol.24, no.3 pp.175-183. Available from: doi:10.11637/aba.2011.24.3.175

Moon Yeon Hee, Jee-Hae Kang, 정남중, 고현미, 이은주, 김선헌, 김민석 "Expression of Tissue Inhibitors of Metalloproteinases in Developing Rat Tooth Germs" Anatomy & Biological Anthropology 24.3 pp.175-183 (2011) : 175.

Moon Yeon Hee, Jee-Hae Kang, 정남중, 고현미, 이은주, 김선헌, 김민석. Expression of Tissue Inhibitors of Metalloproteinases in Developing Rat Tooth Germs. 2011; 24(3), 175-183. Available from: doi:10.11637/aba.2011.24.3.175

Moon Yeon Hee, Jee-Hae Kang, 정남중, 고현미, 이은주, 김선헌 and 김민석. "Expression of Tissue Inhibitors of Metalloproteinases in Developing Rat Tooth Germs" Anatomy & Biological Anthropology 24, no.3 (2011) : 175-183.doi: 10.11637/aba.2011.24.3.175

Moon Yeon Hee; Jee-Hae Kang; 정남중; 고현미; 이은주; 김선헌; 김민석. Expression of Tissue Inhibitors of Metalloproteinases in Developing Rat Tooth Germs. Anatomy & Biological Anthropology, 24(3), 175-183. doi: 10.11637/aba.2011.24.3.175

Moon Yeon Hee; Jee-Hae Kang; 정남중; 고현미; 이은주; 김선헌; 김민석. Expression of Tissue Inhibitors of Metalloproteinases in Developing Rat Tooth Germs. Anatomy & Biological Anthropology. 2011; 24(3) 175-183. doi: 10.11637/aba.2011.24.3.175

Moon Yeon Hee, Jee-Hae Kang, 정남중, 고현미, 이은주, 김선헌, 김민석. Expression of Tissue Inhibitors of Metalloproteinases in Developing Rat Tooth Germs. 2011; 24(3), 175-183. Available from: doi:10.11637/aba.2011.24.3.175

Moon Yeon Hee, Jee-Hae Kang, 정남중, 고현미, 이은주, 김선헌 and 김민석. "Expression of Tissue Inhibitors of Metalloproteinases in Developing Rat Tooth Germs" Anatomy & Biological Anthropology 24, no.3 (2011) : 175-183.doi: 10.11637/aba.2011.24.3.175