@article{ART001588835},
author={Kwang-Jin Kim and 곽한복 and 최은영 and 오재민 and 최민규 and 이정휴 and 송미진 and 안용환 and 이명수 and Chang Hoon Lee and 박성훈 and 김명희 and 김성환 and 박기인 and 김광미 and 김하영 and 문서영 and 김정중 and 채수욱},
title={Inhibitory Effects of 1′,2′-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2011},
volume={24},
number={3},
pages={165-174},
doi={10.11637/aba.2011.24.3.165}
TY - JOUR
AU - Kwang-Jin Kim
AU - 곽한복
AU - 최은영
AU - 오재민
AU - 최민규
AU - 이정휴
AU - 송미진
AU - 안용환
AU - 이명수
AU - Chang Hoon Lee
AU - 박성훈
AU - 김명희
AU - 김성환
AU - 박기인
AU - 김광미
AU - 김하영
AU - 문서영
AU - 김정중
AU - 채수욱
TI - Inhibitory Effects of 1′,2′-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo
JO - Anatomy & Biological Anthropology
PY - 2011
VL - 24
IS - 3
PB - 대한체질인류학회
SP - 165
EP - 174
SN - 2671-5651
AB - It is important to identify therapeutic compounds with no adverse effects for use in the chemotherapy of patients with bone-related diseases. The aim of this study was to identify a new compound that inhibits osteoclast differentiation and bone resorption. Herein, we examined the effects of 1′,2′-dihydrorotenone on osteoclast differentiation and bone resorption in vitro and in vivo. 1′,2′-dihydrorotenone inhibited receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation of cultured bone marrow macrophages (BMMs) in a dosedependent manner. However, 1′,2′-dihydrorotenone did not exert cytotoxic effect on BMMs. 1′,2′-dihydrorotenone suppressed the expression of c-fos and NFATc1 as well as osteoclast-specific genes in BMMs treated with RANKL.
Treatment with RANKL inhibited the expression of inhibitors of differentiation/DNA binding (Id)1, 2, and 3; however,in the presence of 1′,2′-dihydrorotenone, RANKL did not suppress the expression of Id1, 2, and 3. Furthermore,1′,2′-dihydrorotenone inhibited bone resorption and considerably attenuated the erosion of trabecular bone induced by lipopolysaccharide treatment. Taken together, these results suggest that 1′,2′-dihydrorotenone has the potential to be applied in therapies for bone-related diseases.
KW - Osteoclast;RANKL;1′;2′-dihydrorotenone;Resorption
DO - 10.11637/aba.2011.24.3.165
ER -
Kwang-Jin Kim, 곽한복, 최은영, 오재민, 최민규, 이정휴, 송미진, 안용환, 이명수, Chang Hoon Lee, 박성훈, 김명희, 김성환, 박기인, 김광미, 김하영, 문서영, 김정중 and 채수욱. (2011). Inhibitory Effects of 1′,2′-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo. Anatomy & Biological Anthropology, 24(3), 165-174.
Kwang-Jin Kim, 곽한복, 최은영, 오재민, 최민규, 이정휴, 송미진, 안용환, 이명수, Chang Hoon Lee, 박성훈, 김명희, 김성환, 박기인, 김광미, 김하영, 문서영, 김정중 and 채수욱. 2011, "Inhibitory Effects of 1′,2′-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo", Anatomy & Biological Anthropology, vol.24, no.3 pp.165-174. Available from: doi:10.11637/aba.2011.24.3.165
Kwang-Jin Kim, 곽한복, 최은영, 오재민, 최민규, 이정휴, 송미진, 안용환, 이명수, Chang Hoon Lee, 박성훈, 김명희, 김성환, 박기인, 김광미, 김하영, 문서영, 김정중, 채수욱 "Inhibitory Effects of 1′,2′-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo" Anatomy & Biological Anthropology 24.3 pp.165-174 (2011) : 165.
Kwang-Jin Kim, 곽한복, 최은영, 오재민, 최민규, 이정휴, 송미진, 안용환, 이명수, Chang Hoon Lee, 박성훈, 김명희, 김성환, 박기인, 김광미, 김하영, 문서영, 김정중, 채수욱. Inhibitory Effects of 1′,2′-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo. 2011; 24(3), 165-174. Available from: doi:10.11637/aba.2011.24.3.165
Kwang-Jin Kim, 곽한복, 최은영, 오재민, 최민규, 이정휴, 송미진, 안용환, 이명수, Chang Hoon Lee, 박성훈, 김명희, 김성환, 박기인, 김광미, 김하영, 문서영, 김정중 and 채수욱. "Inhibitory Effects of 1′,2′-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo" Anatomy & Biological Anthropology 24, no.3 (2011) : 165-174.doi: 10.11637/aba.2011.24.3.165
Kwang-Jin Kim; 곽한복; 최은영; 오재민; 최민규; 이정휴; 송미진; 안용환; 이명수; Chang Hoon Lee; 박성훈; 김명희; 김성환; 박기인; 김광미; 김하영; 문서영; 김정중; 채수욱. Inhibitory Effects of 1′,2′-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo. Anatomy & Biological Anthropology, 24(3), 165-174. doi: 10.11637/aba.2011.24.3.165
Kwang-Jin Kim; 곽한복; 최은영; 오재민; 최민규; 이정휴; 송미진; 안용환; 이명수; Chang Hoon Lee; 박성훈; 김명희; 김성환; 박기인; 김광미; 김하영; 문서영; 김정중; 채수욱. Inhibitory Effects of 1′,2′-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo. Anatomy & Biological Anthropology. 2011; 24(3) 165-174. doi: 10.11637/aba.2011.24.3.165
Kwang-Jin Kim, 곽한복, 최은영, 오재민, 최민규, 이정휴, 송미진, 안용환, 이명수, Chang Hoon Lee, 박성훈, 김명희, 김성환, 박기인, 김광미, 김하영, 문서영, 김정중, 채수욱. Inhibitory Effects of 1′,2′-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo. 2011; 24(3), 165-174. Available from: doi:10.11637/aba.2011.24.3.165
Kwang-Jin Kim, 곽한복, 최은영, 오재민, 최민규, 이정휴, 송미진, 안용환, 이명수, Chang Hoon Lee, 박성훈, 김명희, 김성환, 박기인, 김광미, 김하영, 문서영, 김정중 and 채수욱. "Inhibitory Effects of 1′,2′-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo" Anatomy & Biological Anthropology 24, no.3 (2011) : 165-174.doi: 10.11637/aba.2011.24.3.165
