Association of Corpora Amylacea Formation with Astrocytes and Cerebrospinal Fluid in the Aged Human Brain

남인혜; Dong Woon Kim (김동운); Hee-Jung Song (송희정); Kim Sooil (김수일); 이건수; Lee， Young Ho (이영호)

doi:10.11637/aba.2012.25.4.177

Association of Corpora Amylacea Formation with Astrocytes and Cerebrospinal Fluid in the Aged Human Brain

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2012, 25(4), pp.177~184
DOI : 10.11637/aba.2012.25.4.177
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

남인혜 ¹, Dong Woon Kim ¹, Hee-Jung Song ¹, Kim Sooil ¹, 이건수 ¹, Lee， Young Ho ¹

¹충남대학교

Accredited

ABSTRACT

Corpora amylacea (CA) are glycoproteinaceous inclusions that accumulate in the human brain during normal aging and neurodegenerative diseases. Although it has been suggested that the cellular sources of CA are neuronal or glial, the mechanisms underlying CA formation remain controversial. The aim of this study was to identify the source of CA in the human brain. Sample of the human brain tissues were obtained from the cadavers. H-E stain, periodic acid-Schiff (PAS) stain, and immunohistochemistry were performed in the brain tissues. Experimental induction of CA was also performed in rats. CA have been found in large numbers in the superficial, rather than in the deep, layer of the white matter in the lateral ventricle that is in contact with the cerebrospinal fluid (CSF) and sometimes near the blood vessels. Destroyed choroid plexi with psammoma bodies have been observed in the lateral ventricle of aged brains containing substantial numbers of CA. The cores of CA were mainly composed of amorphous PAS-positive materials, and glial fibrillary acidic protein-positive astrocytic processes were attached to the surface of the CA. Weak MAP2 was detected on a few CA in the gray matter such as dentate gyrus. PAS-positive CA were located on the border of the hippocampus contacting the CSF in the lateral ventricle in the cysteamine-induced CA animal model. Taken together, main cellular source of CA is astrocytes and CA core formation may be associated with CSF in the aged human brain.

KEYWORDS

Corpora amylacea, Brain, Aging, Astrocytes, Cerebrospinal fluid, Choroid plexus

Citation status

* References for papers published after 2023 are currently being built.

[journal] Abel TJ / 2010 / Parahippocampal corpora amylacea: case report / Neurosurgery 66 : E1206~E1207

[journal] Cavanagh JB / 1999 / Corpora-amylacea and the family of polyglucosan diseases / Brain Res Brain Res Rev 29 : 265~295

[journal] Chung MH / 1996 / Corpora amylacea: a marker for mesial temporal sclerosis / J Neuropathol Exp Neurol 55 : 403~408

[journal] Cisse S / 1993 / Immunochemical identification of ubiquitin and heatshock proteins in corpora amylacea from normal aged and Alzheimer’s disease brains / Acta Neuropathol 85 : 233~240

[journal] Cisse S / 1995 / Experimental induction of corpora amylacea- like inclusions in rat astroglia / Neuropathol Appl Neurobiol 21 : 423~431

[journal] Felgenhauer K / 1974 / Protein size and cerebrospinal fluid composition / Klin Wochenschr 52 : 1158~1164

[journal] Leel-Ossy L. / 1995 / The occurrence of corpus amylaceum (polyglucosan body) in diabetes mellitus / Neuropathology 15 : 108~111

[journal] Leel-Ossy L. / 2001 / New data on the ultrastructure of the corpus amylaceum(polyglucosan body) / Pathol Oncol Res 7 : 145~150

[journal] Loeffler KU / 1993 / Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve / Invest Ophthalmol Vis Sci 34 : 2600~2603

[journal] Martin JE / 1991 / Heat shock protein expression in corpora amylacea in the central nervous system: clues to their origin / Neuropathol Appl Neurobiol 17 : 113~119

[journal] Maurizi CP. / 2010 / Choroid plexus portals and a deficiency of melatonin can explain the neuropathology of Alzheimer’s disease / Med Hypotheses 74 : 1059~1066

[journal] Meng H / 2009 / Localization of blood proteins thrombospondin1 and ADAMTS13 to cerebral corpora amylacea / Neuropathology 29 : 664~671

[journal] Radhakrishnan A / 2007 / Corpora amylacea in mesial temporal lobe epilepsy: clinico-pathological correlations / Epilepsy Res 74 : 81~90

[journal] Rejdak R / 2011 / Presence of L-kynurenine aminotransferase III in retinal ganglion cells and corpora amylacea in the human retina and optic nerve / Folia Neuropathol 49 : 132~137

[journal] Rejdak R / 2007 / Immunohistochemical identification of kynurenine aminotransferases in corpora amylacea in the human retina and optic nerve / Folia Neuropathol 45 : 66~71

[journal] Sakai M / 1969 / Studies of corpora amylacea. I. Isolation and preliminary characterization by chemical and histochemical techniques / Arch Neurol 21 : 526~544

[journal] Schipper HM / 1995 / Mitochondrial constituents of corpora amylacea and autofluorescent astrocytic inclusions in senescent human brain / Glia 14 : 55~64

[journal] Schipper HM / 1998 / Experimental induction of corpora amylacea in adult rat brain / Microsc Res Tech 43 : 43~48

[journal] Singhrao SK / 1994 / New im- munocytochemical evidence for a neuronal/oligodendroglial origin for corpora amylacea / Neuropathol Appl Neurobiol 20 : 66~73

[journal] Wilhelmus MM / 2009 / Novel role of transglutaminase 1 in corpora amylacea formation? / Neurobiol Aging 32 : 845~856

KJCKorea
Journal Central

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Association of Corpora Amylacea Formation with Astrocytes and Cerebrospinal Fluid in the Aged Human Brain

ABSTRACT

KEYWORDS

Citation status

* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Association of Corpora Amylacea Formation with Astrocytes and Cerebrospinal Fluid in the Aged Human Brain

ABSTRACT

KEYWORDS

Statistics

Tools

Issue List

Citation status

KCI Citation Counts (0)

REFERENCES (20) * References for papers published after 2023 are currently being built.

Search PDF

Citation

* References for papers published after 2023 are currently being built.