Role of IL-10 in the Trimellitic Anhydride-induced Contact Dermatitis (Trimellitic anhydride에 의한 접촉성피부염에서 인터루킨 10의 역할)

김윤규; Chai Ok Hee (채옥희); Song Chang Ho (송창호)

doi:10.11637/aba.2013.26.2.71

Role of IL-10 in the Trimellitic Anhydride-induced Contact Dermatitis

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2013, 26(2), pp.71~79
DOI : 10.11637/aba.2013.26.2.71
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

김윤규 ¹, Chai Ok Hee ², Song Chang Ho ²

¹전북대학교 의학전문대학원 해부학교실, 전북대학교 의과학 연구소
²전북대학교

Accredited

ABSTRACT

Trimellitic anhydride (TMA) is widely used industrially to make epoxy and alkyd resins, plasticizers and surfactants. The purpose of this study was to investigate whether contact dermatitis is induced by repeated TMA challenge and the role of interleukin (IL)-10 in the TMA-induced contact dermatitis. The repetition of the challenge enlarged the extent of an early and a late phase of contact dermatitis in IL-10+/+and IL-10-/- mice. In the late phase of TMA-induced contact dermatitis, the peak of ear swelling responses by single challenge showed at 12 h after challenge, but the peak was observed at 8 h after repeated challenge. In the IL-10-/- mice, the repetition of the TMA challenges enlarged the extent of the contact dermatitis, but less than those in IL-10+/+ mice. These results indicate that mice sensitized by TMA could possibly offer a useful model to study the mechanism of contact dermatitis, and IL-10 may act as potential modulators in the TMA-induced contact dermatitis. IL-10may provide therapeutic tools for the treatment of TMA-induced contact dermatitis.

KEYWORDS

IL-10, Trimellitic anhydride, Contact dermatitis, Ear swelling

Citation status

* References for papers published after 2023 are currently being built.

[journal] Leung D / 2000 / Atopic dermatitis: New insights and opportunities for therapeutic intervention / J Allergy Clin Immunol 105 : 860~876

[journal] 고재완 / 2009 / A Statistical Study of Dermatoses in Goyang City (2004∼2008) / 대한피부과학회지 / 대한피부과학회 47(8) : 896~903

[journal] Ganner LA / 2004 / Contact dermatitis to metals / Dermatol Ther 17 : 321~327

[journal] Martín JM / 2005 / Acute contact eczema from paraphenylenediamine contained in temporary henna tattoos / Actas Dermosifiliogr 96 : 382~385

[journal] Steinkjer B / 2011 / Contact allergy to henna tattoos / Tidsskr Nor Laegeforen 131 : 581~582

[journal] Grabbe S / 1998 / Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity / Immunol Today 19 : 37~44

[journal] Kondo S / 1995 / Interleukin-1 receptor antagonist suppresses contact hypersensitivity / J Invest Dermatol 105 : 334~338

[journal] Piguet PF / 1991 / Tumor necrosis factor is a critical mediator in hapten-induced irritant and contact hypersensitivity reactions / J Exp Med 173 : 673~679

[journal] Wang B / 2003 / Cytokine knoctouts in contact hypersensitivity research / Cytokine Growth Factor Rev 14 : 381~389

[journal] Ray A / 2011 / A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosis / J Neuroimmunol 230 : 1~9

[journal] Di Gioacchino M / 2011 / Immunotoxicity of nanoparticles / Int J Immunopathol Pharmacol 24 : 65S~71S

[journal] Braga M / 2011 / T regulatory cells in allergy / Int J Immunopathol Pharmacol 24 : 55S~64S

[journal] Ouyang W / 2011 / Regulation and functions of the IL-10 family of cytokines in inflammation and disease / Annu Rev Immunol 29 : 71~109

[journal] Asaduliah K / 2003 / Interlekin-10 therpy-review of a new approach / Pharmacol Rev 55 : 241~269

[journal] Mapp C / 1999 / Mechanisms of occupational asthma / Ann Allergy Asthma Immunol 23 : 214~264

[journal] Zhang XD / 2002 / Dose-response and time course of specific IgE and IgG after single and repeated topical skin exposure to dry trimellitic anhydride powder in a Brown Norway rat model / Allergy 57 : 620~626

[journal] 채옥희 / 2005 / Roles of TNF-α and IgE in the late phase of contact hypersensitivity induced by trimellitic anhydride / Experimental and Molecular Medicine / 생화학분자생물학회 37(5) : 408~417

[journal] Song CH / 1999 / 13 congo red staning of intraepithelial mucosal mast cells / J Histochem Cytochem 47 : 1645~1645

[journal] Landsteiner K / 1935 / Studies on the sensitization of animals with simple chemical compounds / J Exp Med 61 : 643~652

[journal] Dvorak AM / 1976 / Morphology of delayed- type hypersensitivity reactions in man. II. Ultrastructural alterations affecting the microvasculature and the tissue mast cells / Lab Invest 34 : 179~191

[journal] Dvorak HF / 1974 / Morphology of delayed-type hypersensitivity reactions in man. I. Quantitative description of the inflammatory response / Lab Invest 31 : 111~130

[journal] Dvorak HF / 1976 / Morphology of delayed- type hypersensitivity reactions in man / J Invest Dermatol 67 : 391~401

[journal] Sugawara Y / 1993 / Skin reactivity in guinea pigs sensitized with 2,4-toluene diisocyanate / Int Arch Allergy Immunol 100 : 190~196

[journal] Ohmen JD / 1995 / Overexpression of IL-10 in atopic drmatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions / J Immunol 154 : 1956~1963

[journal] Asadullah K / 1996 / Progression of mycosis fungoides is associated with increasing cutaneous expression of interleukin 10 mRNA / J Investig Dermatol 107 : 833~837

[journal] Rennick DM / 2000 / Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10-/-) mice and intestinal inflammation / Am J Physiol Gastrointest Liver Physiol 278 : 829~833

[journal] Vignali DA / 2008 / How regulatory T cells work / Nat Rev Immunol 8 : 523~532

This paper was written with support from the National Research Foundation of Korea.

KJCKorea
Journal Central

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Role of IL-10 in the Trimellitic Anhydride-induced Contact Dermatitis

ABSTRACT

KEYWORDS

Citation status

* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Role of IL-10 in the Trimellitic Anhydride-induced Contact Dermatitis

ABSTRACT

KEYWORDS

Statistics

Tools

Issue List

Citation status

KCI Citation Counts (1)

REFERENCES (27) * References for papers published after 2023 are currently being built.

Search PDF

Citation

* References for papers published after 2023 are currently being built.