Podocyte-specific Expression of C1q/TNF-α Related Protein 1 in Mice

Keun-Ja Cho (조근자); Young Yang (양영); Lee， Young Ho (이영호); Kim Sooil (김수일)

doi:10.11637/aba.2013.26.4.147

Podocyte-specific Expression of C1q/TNF-α Related Protein 1 in Mice

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2013, 26(4), pp.147~153
DOI : 10.11637/aba.2013.26.4.147
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

Keun-Ja Cho ¹, Young Yang ², Lee， Young Ho ³, Kim Sooil ³

¹공주대학교
²숙명여자대학교
³충남대학교

Accredited

ABSTRACT

C1q/TNF-α Related Protein 1 (CTRP1), an adiponectin paralog, is a novel member of the C1q-TNF Related Protein family. CTRP1 is expressed in the kidney, although its localization and role in the kidney have not been studied. This study examined CTRP1 expression and function in the kidney. CTRP1 immunohistochemistry and PAS staining of the kidneys of C57/BL6 and FGS/Nga mice were performed. In situ hybridization for podocin in the kidney was also performed. CTRP1 immunoreactivity was found only in the glomeruli of the kidney. The CTRP1-immunoreactive cells in the glomeruli were identified as podocytes. The number of CTPR1-immunoreactive cells and the intensity of CTRP1 immunoreactivity were lower in the glomeruli of FGS/Nga mice, which develop progressive proteinuria and focal glomerulosclerosis. CTRP1 is a novel protein expressed in podocytes of the mouse kidney and may have a role in podocytes related to glomerular filtration in the kidney.

KEYWORDS

Podocyte, CTRP1, Glomerulosclerosis, Proteinuria, Glomerular filtration

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Podocyte-specific Expression of C1q/TNF-α Related Protein 1 in Mice

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Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Podocyte-specific Expression of C1q/TNF-α Related Protein 1 in Mice

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