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@article{ART001885711},
author={Guanghai Yan and Choi Yun Ho},
title={Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2014},
volume={27},
number={2},
pages={79-90},
doi={10.11637/aba.2014.27.2.79}

TY - JOUR
AU - Guanghai Yan
AU - Choi Yun Ho
TI - Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma
JO - Anatomy & Biological Anthropology
PY - 2014
VL - 27
IS - 2
PB - 대한체질인류학회
SP - 79
EP - 90
SN - 2671-5651
AB - Medicinal mushrooms have been shown to have profound health promoting benefits. Among them,Lentinus edodes is well-known to have anti-tumor, anti-inflammatory, and immunomodulatory effects. The aimof the present study is to evaluate whether Lentinus edodes ethanol extract (LE) inhibit airway inflammatoryresponse in a murine asthma model induced by exposure to ovalbumin (OVA). The pretreatment of LE substantiallyattenuated airway hyperresponsiveness and eosinophilic inflammation in OVA-challenged mice. Inaddition, the increased levels of Th2 cytokines (IL-4, IL-5, and IL-13), eotaxin, and adhesion molecules inbronchoalveolar lavage fluids at 48 h after OVA inhalation was significantly reduced by the administration of LE. Furthermore, LE suppressed OVA-induced activation of nuclear factor-kappa B and p38 mitogen-activatedprotein kinase in lung tissues. Taken together, it is proposed that LE may serve as an effective therapeutic agentfor allergic airway disease.
KW - Lentinus edodes;Asthma;Allergic inflammation;Th2 cytokine;NF-κB
DO - 10.11637/aba.2014.27.2.79
ER -

Guanghai Yan and Choi Yun Ho. (2014). Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma. Anatomy & Biological Anthropology, 27(2), 79-90.

Guanghai Yan and Choi Yun Ho. 2014, "Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma", Anatomy & Biological Anthropology, vol.27, no.2 pp.79-90. Available from: doi:10.11637/aba.2014.27.2.79

Guanghai Yan, Choi Yun Ho "Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma" Anatomy & Biological Anthropology 27.2 pp.79-90 (2014) : 79.

Guanghai Yan, Choi Yun Ho. Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma. 2014; 27(2), 79-90. Available from: doi:10.11637/aba.2014.27.2.79

Guanghai Yan and Choi Yun Ho. "Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma" Anatomy & Biological Anthropology 27, no.2 (2014) : 79-90.doi: 10.11637/aba.2014.27.2.79

Guanghai Yan; Choi Yun Ho. Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma. Anatomy & Biological Anthropology, 27(2), 79-90. doi: 10.11637/aba.2014.27.2.79

Guanghai Yan; Choi Yun Ho. Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma. Anatomy & Biological Anthropology. 2014; 27(2) 79-90. doi: 10.11637/aba.2014.27.2.79

Guanghai Yan, Choi Yun Ho. Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma. 2014; 27(2), 79-90. Available from: doi:10.11637/aba.2014.27.2.79

Guanghai Yan and Choi Yun Ho. "Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma" Anatomy & Biological Anthropology 27, no.2 (2014) : 79-90.doi: 10.11637/aba.2014.27.2.79