Immunohistochemical Study of O-GlcNAcylation in Human Skin Tumors

Young Lee (이영); 홍동균; 최대경; 임슬기; 손경철; Im Myung (임명); Young-Joon Seo (서영준); Lee， Young Ho (이영호); 이중훈; Kim Chang Deok (김창덕)

doi:10.11637/aba.2014.27.2.71

Immunohistochemical Study of O-GlcNAcylation in Human Skin Tumors

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2014, 27(2), pp.71~77
DOI : 10.11637/aba.2014.27.2.71
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

Young Lee ¹, 홍동균 ¹, 최대경 ¹, 임슬기 ¹, 손경철 ¹, Im Myung ², Young-Joon Seo ¹, Lee， Young Ho ¹, 이중훈 ¹, Kim Chang Deok ¹

¹충남대학교
²충남대학교병원

Accredited

ABSTRACT

O-linked β-N-acetylglucosamine modification is an important post-translational modification,emerging as a novel regulatory mechanism in various cellular events. Recently, several studies have shown thatO-GlcNAcylation plays an essential role in human breast, lung, and colon cancers. With regard to skin cancers,the role of O-GlcNAcylation has yet to be elucidated. To investigate whether O-GlcNAcylation is linked tohuman skin tumor development, immunohistochemical analysis was performed to investigate the presence of OGlcNAcylationin various skin tumors. We evaluated the levels of O-GlcNAcylation, O-GlcNAc transferase, andO-GlcNAcase in 29 benign tumors, 12 premalignant tumors, and 26 malignant tumors in skin. Compared to thebenign tumors, premalignant and malignant tumors had increased patterns of O-GlcNAcylation. In addition, theO-GlcNAc transferase and O-GlcNAcase levels were higher in premalignant and malignant tumors than in benigntumors. Interestingly, O-GlcNAcase levels were significantly increased in premalignant tumors compared tobenign and malignant tumors. These results suggest that O-GlcNAcylation of proteins may play an important rolein the development of human skin tumors.

KEYWORDS

Immunohistochemistry, O-GlcNAc, O-GlcNAcase, O-GlcNAc transferase, Skin neoplasm

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Immunohistochemical Study of O-GlcNAcylation in Human Skin Tumors

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Immunohistochemical Study of O-GlcNAcylation in Human Skin Tumors

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