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@article{ART002537048},
author={Moon Daeun and Sang-Pil Yoon and Hee-Seong Jang and Mi Ra Noh and Ligyeom Ha and Babu J. Padanilam and Jinu Kim},
title={Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2019},
volume={32},
number={4},
pages={121-128},
doi={10.11637/aba.2019.32.4.121}

TY - JOUR
AU - Moon Daeun
AU - Sang-Pil Yoon
AU - Hee-Seong Jang
AU - Mi Ra Noh
AU - Ligyeom Ha
AU - Babu J. Padanilam
AU - Jinu Kim
TI - Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells
JO - Anatomy & Biological Anthropology
PY - 2019
VL - 32
IS - 4
PB - 대한체질인류학회
SP - 121
EP - 128
SN - 2671-5651
AB - Calcitonin gene-related peptide (CGRP) is the most abundant neuropeptide in primary afferent sensory neurons. Exogenous CGRP can induce cell death in kidney tubular cells. The objective of this study was to determine whether exogenous CGRP could induce reactive oxygen species (ROS) production in kidney proximal tubule epithelial cells and whether CGRP-induced ROS production might contribute to cell death. In HK-2, LLCPK1 and TCMK-1 cell lines derived from human, pig, and mouse respectively, administration of CGRP increased cell death in time- and dose-dependent manners, as demonstrated by decreased cell viability. Exogenous CGRP also increased ROS production levels in those cell lines. Treatment with CGRP receptor antagonist (CGRP8-37) significantly inhibited the increases in cell death and ROS production in CGRP-exposed cells. Furthermore, treatment with a ROS scavenger (MnTMPyP) markedly reduced kidney proximal tubule epithelial cell death after CGRP administration. Taken together, these data suggest that extraneural CGRP can induce cell death through excessive oxidative stress in kidney proximal tubule epithelial cells.
KW - CGRP;Kidney proximal tubule epithelial cell;Cell death;ROS;Oxidative stress;CGRP8-37;MnTMPyP
DO - 10.11637/aba.2019.32.4.121
ER -

Moon Daeun, Sang-Pil Yoon, Hee-Seong Jang, Mi Ra Noh, Ligyeom Ha, Babu J. Padanilam and Jinu Kim. (2019). Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells. Anatomy & Biological Anthropology, 32(4), 121-128.

Moon Daeun, Sang-Pil Yoon, Hee-Seong Jang, Mi Ra Noh, Ligyeom Ha, Babu J. Padanilam and Jinu Kim. 2019, "Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells", Anatomy & Biological Anthropology, vol.32, no.4 pp.121-128. Available from: doi:10.11637/aba.2019.32.4.121

Moon Daeun, Sang-Pil Yoon, Hee-Seong Jang, Mi Ra Noh, Ligyeom Ha, Babu J. Padanilam, Jinu Kim "Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells" Anatomy & Biological Anthropology 32.4 pp.121-128 (2019) : 121.

Moon Daeun, Sang-Pil Yoon, Hee-Seong Jang, Mi Ra Noh, Ligyeom Ha, Babu J. Padanilam, Jinu Kim. Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells. 2019; 32(4), 121-128. Available from: doi:10.11637/aba.2019.32.4.121

Moon Daeun, Sang-Pil Yoon, Hee-Seong Jang, Mi Ra Noh, Ligyeom Ha, Babu J. Padanilam and Jinu Kim. "Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells" Anatomy & Biological Anthropology 32, no.4 (2019) : 121-128.doi: 10.11637/aba.2019.32.4.121

Moon Daeun; Sang-Pil Yoon; Hee-Seong Jang; Mi Ra Noh; Ligyeom Ha; Babu J. Padanilam; Jinu Kim. Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells. Anatomy & Biological Anthropology, 32(4), 121-128. doi: 10.11637/aba.2019.32.4.121

Moon Daeun; Sang-Pil Yoon; Hee-Seong Jang; Mi Ra Noh; Ligyeom Ha; Babu J. Padanilam; Jinu Kim. Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells. Anatomy & Biological Anthropology. 2019; 32(4) 121-128. doi: 10.11637/aba.2019.32.4.121

Moon Daeun, Sang-Pil Yoon, Hee-Seong Jang, Mi Ra Noh, Ligyeom Ha, Babu J. Padanilam, Jinu Kim. Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells. 2019; 32(4), 121-128. Available from: doi:10.11637/aba.2019.32.4.121

Moon Daeun, Sang-Pil Yoon, Hee-Seong Jang, Mi Ra Noh, Ligyeom Ha, Babu J. Padanilam and Jinu Kim. "Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells" Anatomy & Biological Anthropology 32, no.4 (2019) : 121-128.doi: 10.11637/aba.2019.32.4.121