Anti-allergic Effects of Caffeine in an Allergic Rhinitis Mouse Model

Yan Jing Fan; Chun Hua Piao; Thi Van Nguyen; Zhen Nan Yu; Chai Ok Hee (채옥희); Song Chang Ho (송창호)

doi:10.11637/aba.2020.33.1.11

Anti-allergic Effects of Caffeine in an Allergic Rhinitis Mouse Model

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2020, 33(1), pp.11~19
DOI : 10.11637/aba.2020.33.1.11
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy
Received : January 7, 2020
Accepted : July 14, 2020
Published : March 31, 2020

Yan Jing Fan ¹, Chun Hua Piao ², Thi Van Nguyen ², Zhen Nan Yu ², Chai Ok Hee ³, Song Chang Ho ³

¹Department of Anatomy, Jeonbuk National University
²Department of Anatomy, Jeonbuk National University Medical School
³전북대학교

Accredited

ABSTRACT

Caffeine (1, 3, 7-trimethylxanthine) is one of the most widely consumed pharmacologically active products worldwide. Caffeine exhibits various pharmacological activities in central nervous, cardiovascular, and respiratory systems. Additionally, caffeine exhibited anti-inflammatory effects in lipopolysaccharide-challenged rats. However, to our knowledge, the potential anti-inflammatory activity of caffeine in allergic rhinitis (AR) has not yet been investigated. Therefore, in this study, we aimed to examine the anti-allergic effects of caffeine in ovalbumin (OVA)-induced AR in mice. We showed that caffeine attenuated the nasal symptoms, including rubbing and sneezing. It reduced the thickness of the nasal mucosa and alleviated goblet cell hyperplasia in the nasal mucosa. In addition, caffeine ameliorated the inflammation in the lungs and decreased OVA-specific immunoglobulin E (IgE) and IgG1 levels in the serum. It also reduced T helper type 2 (Th2) cytokine (interleukin (IL)-4 and IL-5) levels and elevated Th1 cytokine (IL-12 and IFN-γ) levels in the nasal lavage fluid. Collectively, we suggest that caffeine might have therapeutic effects in AR owing to its anti-inflammatory activities.

KEYWORDS

Caffeine, Allergic rhinitis, Anti-allergic effects, Cytokines

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Anti-allergic Effects of Caffeine in an Allergic Rhinitis Mouse Model

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Anatomy & Biological Anthropology 2024 KCI Impact Factor : 0.36

Anti-allergic Effects of Caffeine in an Allergic Rhinitis Mouse Model

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