Chiral 1,4-oxazepan-3-one Targeting Schwann Cells Exhibits Morphometrically Inhibitory Effects on Wallerian Degeneration

JUNG NA YOUNG (정나영); Hyung-Joo Chung; Sung-Gon Kim (김성곤)

doi:10.11637/aba.2022.35.4.145

Chiral 1,4-oxazepan-3-one Targeting Schwann Cells Exhibits Morphometrically Inhibitory Effects on Wallerian Degeneration

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2022, 35(4), pp.145~151
DOI : 10.11637/aba.2022.35.4.145
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy
Received : November 23, 2022
Accepted : December 7, 2022
Published : December 31, 2022

JUNG NA YOUNG ¹, Hyung-Joo Chung ², Sung-Gon Kim ³

¹동아대학교
²Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Korea
³경기대학교

Accredited

ABSTRACT

Schwann cell is a unique neuroglial cell and has essential functions for regulating Wallerian degeneration and peripheral nerve regeneration after nerve injury. When Wallerian degeneration is inefficient or irreversible due to non-function or malfunction of Schwann cells, peripheral nerve regeneration doesn’t occur and peripheral neurodegenerative diseases are induced, such as diabetic neuropathies. However, effective medicinal therapeutics has not been developed. In this study, we employed a synthesized chiral 1,4-oxazpan-3-one (1,4-DZ) compound to investigate neuroanatomically degenerative characteristics of Schwann cells during Wallerian degeneration. We also used ex vivo sciatic nerve explant system to exclude macrophage effects on demyelination, performed immunostaining by using teased nerve fiber samples to observe the outlook of myelin sheath during Wallerian degeneration, and identified its inhibitory effects on the degeneration. Thus, our results suggested that 1,4-DZ could be a prototype to develop a new small drug for peripheral neurodegenerative diseases.

KEYWORDS

Schwann cells, Peripheral nerve degeneration, Ex vivo culture system, Morphometric analysis, Diazepam derivatives

Citation status

* References for papers published after 2023 are currently being built.

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This paper was written with support from the National Research Foundation of Korea.

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Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Chiral 1,4-oxazepan-3-one Targeting Schwann Cells Exhibits Morphometrically Inhibitory Effects on Wallerian Degeneration

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* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Chiral 1,4-oxazepan-3-one Targeting Schwann Cells Exhibits Morphometrically Inhibitory Effects on Wallerian Degeneration

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* References for papers published after 2023 are currently being built.