Anatomy & Biological Anthropology 2024 KCI Impact Factor : 0.36
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pISSN : 2671-5651 / eISSN : 2671-566X
- https://journal.kci.go.kr/aba
KJCKorea
Journal Central
ZNF821 as a Novel Prognostic Biomarker and its Correlation with Infiltrating Immune Cells in Pancreatic Adenocarcinoma
- Anatomy & Biological Anthropology
- Abbr : Anat Biol Anthropol
- 2024, 37(1), pp.31~43
- DOI : 10.11637/aba.2024.37.1.31
- Publisher : 대한체질인류학회
- Research Area : Medicine and Pharmacy > Anatomy
- Received : December 10, 2023
- Accepted : January 2, 2024
- Published : March 31, 2024
Kang Yun Jeong 1, Kim hye ran 1, Kim Jong Wan 1
1동의과학대학교
Accredited
ABSTRACT
The Zinc Finger Protein 821 (ZNF821) is a human protein that contains the 23 amino acid peptide repeat domain. However, ZNF821 has not been examined as a predictive biomarker. This study evaluated ZNF821, a member of the ZNF domain family, as a prognostic biomarker of various human cancers, including pancreatic adenocarcinoma (PAAD). We also identified a correlation between ZNF821 expression and immune cell infiltration in patients with PAAD. Bioinformatics analysis was performed using online databases such as the University of ALabama at Birmingham CANcer data analysis Portal database analysis, Tumor Immune Estimation Resource, Kaplan-Meier database plotter, LinkedOmics, and Gene Expression Profiling Interactive Analysis version 2. ZNF821 expression in PAAD samples was significantly lower than normal tissue. Additionally, ZNF821 expression was lower in nodal metastasis, primary tumor grade, tumor grade, and cancer stages. Lower ZNF821 expression was also associated with a poorer prognosis in PAAD. ZNF821 expression positively correlated with T cells (CD8+ and CD4+), neutrophils, macrophages, and dendritic cells. In the analysis of the ZNF821 co-expression networks, positively related genes of ZNF821 were associated with a high hazard ratio in different types of cancer, including PAAD. Regarding the biological function of ZNF821, ZNF821 mainly participates in the neuropeptide signaling pathway, monoamine transport, and protein localization in the endoplasmic reticulum. These results suggest that ZNF821 may serve as a novel prognostic biomarker for PAAD diagnosis and provide novel insights into the cancer-immune system in PAAD
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[journal]
Zhang Q
/ 2021
/ Immune subtypes based on immune-related lncRNA : Differential prognostic mechanism of pancreatic cancer
/ Front Cell Dev Biol
9
: 698296~
[journal]
Wu Z
/ 2022
/ Novel necroptosis-related gene signature for predicting the prognosis of pancreatic adenocarcinoma
/ Aging(Albany NY)
14
: 869~891
[journal]
Chi H
/ 2022
/ Cuprotosis programmed-cell-death-related lncRNA signature predicts prognosis and immune landscape in PAAD patients
/ Cells
11
: 3436~3461
[journal]
Stevens RJ
/ 2007
/ Pancreatic cancer in type 1 and young-onset diabetes : systematic review and meta-analysis
/ Br J Cancer
96
: 507~509
[journal]
Machicado JD
/ 2016
/ Epidemiology of chronic pancreatitis
/ Pancreapedia
: 1~15
[journal]
McGuigan A
/ 2018
/ Pancreatic cancer : A review of clinical diagnosis, epidemiology, treatment and outcomes
/ World J Gastroenterol
24
: 4846~4861
[journal]
Canto MI
/ 2013
/ International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer
/ Gut
62
: 339~347
[journal]
Kamisawa T
/ 2016
/ Pancreatic cancer
/ The Lancet
388
: 73~85
[journal]
Aroldi F
/ 2016
/ Pancreatic Cancer : Promises and Failures of Target Therapies
/ Rev Recent Clin Trials
11
: 33~38
[journal]
Huang ZD
/ 2021
/ Molecular subtypes based on cell differentiation trajectories in head and neck squamous cell carcinoma : differential prognosis and immunotherapeutic responses
/ Front Immunol
12
: 791621~791638
[journal]
Kamarajah SK
/ 2017
/ Validation of the American Joint Commission on Cancer(AJCC)8th edition staging system for patients with pancreatic adenocarcinoma : a surveillance, epidemiology and end results(SEER)analysis
/ Ann Surg Oncol
24
: 2023~2030
[journal]
Marabelle A
/ 2017
/ Intratumoral immunotherapy : using the tumor as the remedy
/ Ann Oncol
28
: xii33~xii43
[journal]
Cabrita R
/ 2020
/ Tertiary lymphoid structures improve immunotherapy and survival in melanoma
/ Nature
577
: 561~565
[journal]
Liu LZ
/ 2019
/ CCL15 Recruits Suppressive Monocytes to Facilitate Immune Escape and Disease Progression in Hepatocellular Carcinoma
/ Hepatology
69
: 143~159
[journal]
Turley SJ
/ 2015
/ Immunological hallmarks of stromal cells in the tumour microenvironment
/ Nat Rev Immunol
15
: 669~682
[journal]
Bruni D
/ 2020
/ The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy
/ Nat Rev Cancer
20
: 662~680
[journal]
Zhou J
/ 2021
/ The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity
/ Nat Immunol
22
: 460~470
[journal]
Razmkhah M
/ 2019
/ Mesenchymal stem cells, immune cells and tumor cells crosstalk : a sinister triangle in the tumor microenvironment
/ Curr Stem Cell Res Ther
14
: 43~51
[journal]
Chang JH
/ 2016
/ Role of immune cells in pancreatic cancer from bench to clinical application : an updated review
/ Medicine(Baltimore)
95
: e5541~
[journal]
Binnewies M
/ 2018
/ Understanding the tumor immune microenvironment(TIME)for effective therapy
/ Nat Med
24
: 541~550
[journal]
Tekpli X
/ 2019
/ An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
/ Nat Commun
10
: 5499~
[journal]
Farrow B
/ 2008
/ The Role of the Tumor Microenvironment in the Progression of Pancreatic Cancer
/ J Surg Res
149
: 319~328
[journal]
Caruso RA
/ 2002
/ Rognostic value of intratumoral neutrophils in advanced gastric carcinoma in a high-risk area in northern Italy
/ Mod Pathol
15
: 831~837
[journal]
Hedayat-Evrigh N
/ 2020
/ Genome-wide identification and analysis of variants in domestic and wild bactrian camels using whole-genome sequencing data
/ Int J Genomics
2020
[journal]
Iyer AS
/ 2023
/ The Roles of Zinc Finger Proteins in Colorectal Cancer
/ Int J Mol Sci
24
: 10249~10274
[journal]
Kang HS
/ 2010
/ Gli-similar(Glis)Krüppel-like zinc finger proteins : insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease
/ Histol Histopathol
25
: 1481~1496
[journal]
Liu S
/ 2023
/ Zinc Finger Proteins in the War on Gastric Cancer : Molecular Mechanism and Clinical Potential
/ Cells
12
: 1314~1341
[journal]
Rhie SK
/ 2018
/ ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream of transcription start sites at the majority of CpG island promoters
/ Genome Res
28
: 310~320
[journal]
Jen J
/ 2016
/ Zinc finger proteins in cancer progression
/ J Biomed Sci
23
: 1~9
[journal]
Nonaka Y
/ 2010
/ STPR, a 23-amino acid tandem repeat domain, found in the human function-unknown protein ZNF821
/ Biochemistry
49
: 8367~8375
[journal]
Maglott D
/ 2010
/ Entrez Gene : gene-centered information at NCBI
/ Nucleic Acids Res
39
: D52~D57
[journal]
Goos JA
/ 2019
/ "A de novo substitution in BCL11B leads to loss of interaction with transcriptional complexes and craniosynostosis"
/ Hum Mol Genet
28
: 2501~2513
[journal]
Breen MS
/ 2016
/ Candidate gene networks and blood biomarkers of methamphetamine-associated psychosis : an integrative RNA-sequencing report
/ Transl Psychiatry
6
: e802~e802
[journal]
Fang Y
/ 2020
/ HEATR1 deficiency promotes chemoresistance via upregulating ZNF185 and downregulating SMAD4 in pancreatic cancer
/ J Oncol
2020
: 3189596~
[journal]
Chandrashekar DS
/ 2017
/ UALCAN : A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses
/ Neoplasia
19
: 649~658
[journal]
Györffy B
/ 2010
/ An online survival analysis tool to rapidly assess the effect of 22, 277 genes on breast cancer prognosis using microarray data of 1, 809 patients
/ Breast Cancer Res Treat
123
: 725~731
[journal]
An Y
/ 2020
/ OSlihc : An Online Prognostic BiomarkerAnalysis Tool for Hepatocellular Carcinoma
/ Front Pharmacol
11
: 875~883
[journal]
Vasaikar SV
/ 2018
/ LinkedOmics : analyzing multi-omics data within and across 32 cancer types
/ Nucleic Acids Res
46
: D956~D963
[journal]
Tang Z
/ 2017
/ GEPIA : a web server for cancer and normal gene expression profiling and interactive analyses
/ Nucleic Acids Res
45
: W98~W102
[journal]
Tang Z
/ 2019
/ GEPIA2 : an enhanced web server for large-scale expression profiling and interactive analysis
/ Nucleic Acids Res
47
: W556~W560
[journal]
Zhang X
/ 2022
/ A novel immune-related prognostic signature predicting survival in patients with pancreatic adenocarcinoma
/ J Oncol
: 8909631~8909655
[journal]
Mukherji R
/ 2022
/ The role of immunotherapy in pancreatic cancer
/ Curr Oncol
29
: 6864~6892
[journal]
Rahib L
/ 2014
/ Projecting Cancer Incidence and Deaths to 2030 : The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
/ Cancer Res
74
: 2913~2921
[journal]
Siegel RL
/ 2020
/ Cancer statistics, 2020
/ CA Cancer J Clin
70
: 7~30
[journal]
Balachandran VP
/ 2019
/ Broadening the Impact of Immunotherapy to Pancreatic Cancer : Challenges and Opportunities
/ Gastroenterology
156
: 2056~2072
[journal]
Tang HD
/ 2022
/ The crosstalk between immune infiltration, circulating tumor cells, and metastasis in pancreatic cancer : Identification of HMGB3 from a multiple omics analysis
/ Front Genet
13
: 892177~
[journal]
Chen Q
/ 2020
/ CD73 Acts as a Prognostic Biomarker and Promotes Progression and Immune Escape in Pancreatic Cancer
/ J Cell Mol Med
24
: 8674~8686
[journal]
Chen K
/ 2021
/ Single-Cell RNA-Seq Reveals Dynamic Change in Tumor Microenvironment During Pancreatic Ductal Adenocarcinoma Malignant Progression
/ EBioMedicine
66
: 103315~103328
[journal]
Goswami KK
/ 2017
/ Tumor promoting role of anti-tumor macrophages in tumor microenvironment
/ Cell Immunol
316
: 1~10
[journal]
Munhoz RR
/ 2016
/ Recent advances in understanding anti tumor immunity
/ F1000Res
5
: 2545~2552
[journal]
Ostrand-Rosenberg S
/ 2008
/ Immune surveillance : a balance between protumor and antitumor immunity
/ Curr Opin Genet Dev
18
: 11~18
[journal]
Arenzana TL
/ 2015
/ Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor
/ Genes Dev
29
: 1081~1816
[journal]
Krebs CJ
/ 2014
/ The KRAB zinc finger protein RSL 1 modulates sex-biased gene expression in liver and adipose tissue to maintain metabolic homeostasis
/ Mol Cell Biol
34
: 221~232
[journal]
Ma X
/ 2016
/ ZHX1 inhibits gastric cancer cell growth through inducing cell-cycle arrest and apoptosis
/ J Cancer
7
: 60~68
[journal]
Goos JA
/ 2019
/ A de novo substitution in BCLllB leads to loss of interaction with transcriptional complexes and craniosynostosis
/ Hum Mol Genet
28
: 2501~2513
[journal]
Breen MS
/ 2016
/ Candidate gene networks and blood biomarkers of methamphetamine-associated psychosis : an integrative RNA-sequencing report
/ Transl Psychiatry
6
: e802~e812
[journal]
Wang W
/ 2022
/ Identifies microtubule-binding protein CSPP1 as a novel cancer biomarker associated with ferroptosis and tumor microenvionment
/ Comput Struct Biotechnol J
20
: 3322~3335
[journal]
Maglott D
/ 2010
/ Entrez Gene : gene-centered information at NCBI
/ Nucleic Acids Res
39
: D52~D57
[journal]
Breen S
/ 2016
/ Candidate gene networks and blood biomarkers of methamphetamine-associated psychosis : an integrative RNA-sequencing report
/ Transl Psychiatry
6
: e802~
[journal]
Lianyuan T
/ 2018
/ The predictive value and role of stromal tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma(PDAC)
/ Cancer Biol Ther
19
: 296~305
[journal]
Ju Q
/ 2020
/ NFE2L2 is a potential prognostic biomarker and is correlated with immune infiltration in brain lower grade glioma : a pan-caner analysis
/ Oxid Med Cell Longev
2020
: 3580719~