@article{ART003094674},
author={Kim hye ran and Kim Jong Wan},
title={Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2024},
volume={37},
number={2},
pages={113-120},
doi={10.11637/aba.2024.37.2.113}
TY - JOUR
AU - Kim hye ran
AU - Kim Jong Wan
TI - Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma
JO - Anatomy & Biological Anthropology
PY - 2024
VL - 37
IS - 2
PB - 대한체질인류학회
SP - 113
EP - 120
SN - 2671-5651
AB - The prognostic value of collagen 24A1 (COL24A1) and its association with tumor-infiltrating immune cells (TIICs) in hepatocellular carcinoma (HCC) remains unexplored. In this study, we aimed to evaluate the prognostic value of COL24A1 in HCC via comprehensive web database analysis such as various online databases, including the Tumor Immune Estimation Resource (TIMER), The University of ALabama at Birmingham CANcer data analysis, Kaplan-Meier plotter, and Gene Expression Profiling Interactive Analysis. COL24A1 mRNA expression was found to be upregulated in HCC as compared to that in normal tissues, which was associated with poor prognosis in HCC. Further, COL24A1 expression correlated positively with TIICs, including B cells, CD8+T cells, neutrophils, macrophages, and dendritic cells, which was also associated with poor prognosis in HCC. The TIMER database revealed positive correlations between COL24A1 expression and that of other collagen family members, including, COL1A1, COL5A1, COL16A1 and COL21A1 in HCC. Our findings demonstrate that COL24A1 may potentially serve as a prognostic biomarker in patients with HCC.
KW - Hepatocellular carcinoma;Collagen 24A1;Prognosis;Biomarker;Immune cells
DO - 10.11637/aba.2024.37.2.113
ER -
Kim hye ran and Kim Jong Wan. (2024). Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma. Anatomy & Biological Anthropology, 37(2), 113-120.
Kim hye ran and Kim Jong Wan. 2024, "Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma", Anatomy & Biological Anthropology, vol.37, no.2 pp.113-120. Available from: doi:10.11637/aba.2024.37.2.113
Kim hye ran, Kim Jong Wan "Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma" Anatomy & Biological Anthropology 37.2 pp.113-120 (2024) : 113.
Kim hye ran, Kim Jong Wan. Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma. 2024; 37(2), 113-120. Available from: doi:10.11637/aba.2024.37.2.113
Kim hye ran and Kim Jong Wan. "Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma" Anatomy & Biological Anthropology 37, no.2 (2024) : 113-120.doi: 10.11637/aba.2024.37.2.113
Kim hye ran; Kim Jong Wan. Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma. Anatomy & Biological Anthropology, 37(2), 113-120. doi: 10.11637/aba.2024.37.2.113
Kim hye ran; Kim Jong Wan. Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma. Anatomy & Biological Anthropology. 2024; 37(2) 113-120. doi: 10.11637/aba.2024.37.2.113
Kim hye ran, Kim Jong Wan. Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma. 2024; 37(2), 113-120. Available from: doi:10.11637/aba.2024.37.2.113
Kim hye ran and Kim Jong Wan. "Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma" Anatomy & Biological Anthropology 37, no.2 (2024) : 113-120.doi: 10.11637/aba.2024.37.2.113
