Inspecting post-stroke mechanisms and treatment for stroke recovery

Yurim Kim (김유림); Yoon Young Chung (정윤영); Hyo-In Hwang (황효인); Hye-Kyoung Shin (신혜경); Yong Hyun Jun (전용현)

doi:10.11637/aba.2025.38.3.159

Inspecting post-stroke mechanisms and treatment for stroke recovery

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2025, 38(3), pp.159~164
DOI : 10.11637/aba.2025.38.3.159
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy
Received : August 29, 2025
Accepted : September 26, 2025
Published : September 30, 2025

Yurim Kim ¹, Yoon Young Chung ², Hyo-In Hwang ², Hye-Kyoung Shin ², Yong Hyun Jun ²

¹조선대학교 의학과
²조선대학교 의과대학 해부학교실

Accredited

ABSTRACT

Followed by not only neurological detriment including motor disorders, but also decline in the quality of life, stroke is a well-known major factor of death, worldwide. Plenty of methods to enhance patient recovery and several post-stroke remedies are being explored until now. In this review, post-stroke inflammatory processes, including BBB breakdown and its effect, will be handled along with the work of microglia activation. Necroptosis, a type of cell death as a result of proinflammatory reaction, will also be addressed to specify its mechanism throughout the post-stroke procedure. This review displays those factors in the spotlight these days to deduce progressive poststroke therapeutic approaches, as well as the other participants of the post-stroke inflammatory process such as the work of T cells. Meanwhile, there are some other approaches under investigation related to making out post-stroke recovery advancement. This review handles the utilization of iPSCs (induced pluripotent stem cells) as a promising access toward innovative post-stroke treatment. Furthermore, this review concludes by pointing out some targets that are under research to develop efficacious post-stroke treatment and highlights the directions where the future investigation for effective post-stroke therapeutic approaches have to head for.

KEYWORDS

Stroke, BBB, Microglia, Inflammation, Necroptosis

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Anatomy & Biological Anthropology 2025 KCI Impact Factor : 0.29

Inspecting post-stroke mechanisms and treatment for stroke recovery

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Anatomy & Biological Anthropology 2025 KCI Impact Factor : 0.29

Inspecting post-stroke mechanisms and treatment for stroke recovery

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