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@article{ART003354780},
author={An-Na Bae and Hajin Lee and Hanjeong Yu and Jinsung Yang and Jongho Park},
title={Suppressing CSTB Enhances Therapeutic Efficacy against Liver Cancer},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2026},
volume={39},
number={2},
pages={183-189},
doi={10.11637/aba.2026.39.2.183}

TY - JOUR
AU - An-Na Bae
AU - Hajin Lee
AU - Hanjeong Yu
AU - Jinsung Yang
AU - Jongho Park
TI - Suppressing CSTB Enhances Therapeutic Efficacy against Liver Cancer
JO - Anatomy & Biological Anthropology
PY - 2026
VL - 39
IS - 2
PB - 대한체질인류학회
SP - 183
EP - 189
SN - 2671-5651
AB - Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and remains the leading cause of cancer-related deaths. The identification of reliable biomarkers for HCC is urgently needed to improve prognosis and treatment outcomes. Cystatin B (CSTB), a member of the cysteine protease inhibitor superfamily, is known to maintain cellular homeostasis and plays a key role in neuronal stability, but its role in HCC development is not fully understood. In this study, we investigated the prognostic significance of CSTB in HCC. CSTB gene expression was markedly elevated in patients with HCC and high CSTB expression was significantly associated with poorer overall survival. We also found that several HCC cell lines exhibited substantially higher CSTB protein levels compared with other cancer cell lines, especially, PLC/PRF/5. Furthermore, knockdown of CSTB reduced the cell viability of HCC cell lines. These findings suggest that targeting CSTB in HCC with specific inhibitors may represent a potential therapeutic approach for HCC.
KW - CSTB;Hepatocellular carcinoma;Biomarker
DO - 10.11637/aba.2026.39.2.183
ER -

An-Na Bae, Hajin Lee, Hanjeong Yu, Jinsung Yang and Jongho Park. (2026). Suppressing CSTB Enhances Therapeutic Efficacy against Liver Cancer. Anatomy & Biological Anthropology, 39(2), 183-189.

An-Na Bae, Hajin Lee, Hanjeong Yu, Jinsung Yang and Jongho Park. 2026, "Suppressing CSTB Enhances Therapeutic Efficacy against Liver Cancer", Anatomy & Biological Anthropology, vol.39, no.2 pp.183-189. Available from: doi:10.11637/aba.2026.39.2.183

An-Na Bae, Hajin Lee, Hanjeong Yu, Jinsung Yang, Jongho Park "Suppressing CSTB Enhances Therapeutic Efficacy against Liver Cancer" Anatomy & Biological Anthropology 39.2 pp.183-189 (2026) : 183.

An-Na Bae, Hajin Lee, Hanjeong Yu, Jinsung Yang, Jongho Park. Suppressing CSTB Enhances Therapeutic Efficacy against Liver Cancer. 2026; 39(2), 183-189. Available from: doi:10.11637/aba.2026.39.2.183

An-Na Bae, Hajin Lee, Hanjeong Yu, Jinsung Yang and Jongho Park. "Suppressing CSTB Enhances Therapeutic Efficacy against Liver Cancer" Anatomy & Biological Anthropology 39, no.2 (2026) : 183-189.doi: 10.11637/aba.2026.39.2.183

An-Na Bae; Hajin Lee; Hanjeong Yu; Jinsung Yang; Jongho Park. Suppressing CSTB Enhances Therapeutic Efficacy against Liver Cancer. Anatomy & Biological Anthropology, 39(2), 183-189. doi: 10.11637/aba.2026.39.2.183

An-Na Bae; Hajin Lee; Hanjeong Yu; Jinsung Yang; Jongho Park. Suppressing CSTB Enhances Therapeutic Efficacy against Liver Cancer. Anatomy & Biological Anthropology. 2026; 39(2) 183-189. doi: 10.11637/aba.2026.39.2.183

An-Na Bae, Hajin Lee, Hanjeong Yu, Jinsung Yang, Jongho Park. Suppressing CSTB Enhances Therapeutic Efficacy against Liver Cancer. 2026; 39(2), 183-189. Available from: doi:10.11637/aba.2026.39.2.183

An-Na Bae, Hajin Lee, Hanjeong Yu, Jinsung Yang and Jongho Park. "Suppressing CSTB Enhances Therapeutic Efficacy against Liver Cancer" Anatomy & Biological Anthropology 39, no.2 (2026) : 183-189.doi: 10.11637/aba.2026.39.2.183